Major trends affecting the future of the United States and the world will dramatically reshape transportation priorities and needs. The American Association of State Highway and Transportation Officials established the National Cooperative Highway Research Program (NCHRP) Project 20-83 research series to examine global and domestic long-range strategic issues and their implications for departments of transportation (DOTs) to help prepare the DOTs for the challenges and benefits created by these trends. NCHRP Report 750: Strategic Issues Facing Transportation, Volume 2: Climate Change, Extreme Weather Events, and the Highway System: Practitioner’s Guide and Research Report is the second report in this series. This report presents guidance on adaptation strategies to likely impacts of climate change through 2050 in the planning, design, construction, operation, and maintenance of infrastructure assets in the United States (and through 2100 for sea-level rise).In addition to the practitioner’s guide and research report, this project also developed the following items: 1) a software tool that runs in common web browsers and provides specific, region-based information on incorporating climate change adaptation into the planning and design of bridges, culverts, stormwater infrastructure, slopes, walls, and pavements; 2) tables that provide the same information as the previously mentioned software tool, but in a spreadsheet format that can be printed; and 3) two spreadsheets that illustrate examples of the benefit-cost analysis of adaptation strategies discussed in Appendix B of Part I of NCHRP Report 750, Volume 2. These three items are available on a CD-ROM (CRP-CD-146) that is included with a print version of the report. The CD-ROM is also available for download from TRB’s website as an ISO image.