Red cell DAMPs and inflammation

[1]  M. Kaplan,et al.  At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases , 2016, Journal of leukocyte biology.

[2]  Yu Wang,et al.  Toll-like receptors mediating vascular malfunction: Lessons from receptor subtypes. , 2016, Pharmacology & therapeutics.

[3]  Shailesh Singh,et al.  Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent , 2015, PloS one.

[4]  R. Webb,et al.  Toll-like Receptors in the Vascular System: Sensing the Dangers Within , 2016, Pharmacological Reviews.

[5]  W. Barcellini,et al.  Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia , 2015, Disease markers.

[6]  T. Ren,et al.  IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production , 2015, Journal of Translational Medicine.

[7]  Jianxun Lei,et al.  Hemin-Induced Mast Cell-Extracellular Traps Impart Resistance to Therapy in a Sickle Microenvironment , 2015 .

[8]  R. Sluyter P2X and P2Y receptor signaling in red blood cells , 2015, Front. Mol. Biosci..

[9]  S. Reddy,et al.  Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases , 2015, Current opinion in lipidology.

[10]  M. Tang,et al.  Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy , 2015, Disease Models & Mechanisms.

[11]  M. Henriques,et al.  Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain , 2015, Mediators of inflammation.

[12]  S. Hansson,et al.  The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators , 2015, PloS one.

[13]  S. Ragab,et al.  Haptoglobin genotypes polymorphism as a risk factor for subclinical atherosclerosis in beta-thalassemia major children; a single center Egyptian study , 2015, Hematology.

[14]  D. Covas,et al.  Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea. , 2015, Blood.

[15]  A. Manda-Handzlik,et al.  Neutrophil extracellular traps (Nets) impact upon autoimmune disorders , 2015, Central-European journal of immunology.

[16]  M. Gladwin,et al.  Red Blood Cells Store and Release Interleukin-33 , 2015, Journal of Investigative Medicine.

[17]  P. Vicari,et al.  Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia , 2015, Revista brasileira de hematologia e hemoterapia.

[18]  A. Warnatsch,et al.  Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis , 2015, Science.

[19]  R. Padmore Possible mechanisms for intravenous immunoglobulin–associated hemolysis: clues obtained from review of clinical case reports , 2015, Transfusion.

[20]  Haitao Guo,et al.  Inflammasomes: mechanism of action, role in disease, and therapeutics , 2015, Nature Medicine.

[21]  R. Locksley,et al.  Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. , 2015, Immunity.

[22]  L. Kiger,et al.  Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease. , 2015, Blood.

[23]  T. Sumpter,et al.  New dog and new tricks: evolving roles for IL‐33 in type 2 immunity , 2015, Journal of leukocyte biology.

[24]  K. Fitzgerald,et al.  Mechanisms of inflammasome activation: recent advances and novel insights. , 2015, Trends in cell biology.

[25]  Si Ming Man,et al.  Regulation of inflammasome activation , 2015, Immunological reviews.

[26]  A. Alayash,et al.  Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease. , 2015, Blood cells, molecules & diseases.

[27]  J. Simard,et al.  Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage , 2015, International journal of molecular sciences.

[28]  S. Ragab,et al.  Study of Serum Haptoglobin Level and its Relation to Erythropoietic Activity in Beta Thalassemia Children , 2015, Mediterranean journal of hematology and infectious diseases.

[29]  Sarah L. Doyle,et al.  Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives , 2015, Journal of inflammation research.

[30]  J. Nichols,et al.  Iron, Inflammation, and Early Death in Adults With Sickle Cell Disease , 2015, Circulation research.

[31]  A. Alayash,et al.  Characterization of heme binding to recombinant α1-microglobulin , 2014, Front. Physiol..

[32]  E. Latz,et al.  IL–1β and IL–18: inflammatory markers or mediators of hypertension? , 2014, British journal of pharmacology.

[33]  I. Boldogh,et al.  Oxidative modification enhances the immunostimulatory effects of extracellular mitochondrial DNA on plasmacytoid dendritic cells. , 2014, Free radical biology & medicine.

[34]  Takayuki Takahashi,et al.  Heme‐related molecules induce rapid production of neutrophil extracellular traps , 2014, Transfusion.

[35]  D. Pennington,et al.  Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. , 2014, Biochimica et biophysica acta.

[36]  P. Buehler,et al.  Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development , 2014, Front. Physiol..

[37]  R. Gonzalez,et al.  Blood transfusion products contain mitochondrial DNA damage-associated molecular patterns: a potential effector of transfusion-related acute lung injury. , 2014, The Journal of surgical research.

[38]  D. Golenbock,et al.  Hemolysis-induced lethality involves inflammasome activation by heme , 2014, Proceedings of the National Academy of Sciences.

[39]  G. Langsley,et al.  ATP, an extracellular signaling molecule in red blood cells: A messenger for malaria? , 2014, Biomedical journal.

[40]  Davide Ferrari,et al.  Extracellular nucleotide and nucleoside signaling in vascular and blood disease. , 2014, Blood.

[41]  W. Junger,et al.  Plasma ATP is Required for Neutrophil Activation in a Mouse Sepsis Model , 2014, Shock.

[42]  V. Natarajan,et al.  Reactive oxygen species at the crossroads of inflammasome and inflammation , 2014, Front. Physiol..

[43]  D. Wagner,et al.  Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. , 2014, Blood.

[44]  S. Hornemann,et al.  ASC has extracellular and prionoid activities that propagate inflammation , 2014, Nature Immunology.

[45]  M. Idzko,et al.  Nucleotide signalling during inflammation , 2014, Nature.

[46]  Hailin Zhao,et al.  Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury. , 2014, American journal of physiology. Renal physiology.

[47]  M. Bozza,et al.  Heme on innate immunity and inflammation , 2014, Front. Pharmacol..

[48]  J. Linden,et al.  The role of adenosine signaling in sickle cell therapeutics. , 2014, Hematology/oncology clinics of North America.

[49]  C. Hoppe Inflammatory mediators of endothelial injury in sickle cell disease. , 2014, Hematology/oncology clinics of North America.

[50]  J. Olson,et al.  Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. , 2014, Free radical biology & medicine.

[51]  N. Conran Intravascular Hemolysis: A Disease Mechanism Not to Be Ignored , 2014, Acta Haematologica.

[52]  U. Udomsubpayakul,et al.  Intravascular Hemolysis, Vascular Endothelial Cell Activation and Thrombophilia in Splenectomized Patients with Hemoglobin E/β-Thalassemia Disease , 2014, Acta Haematologica.

[53]  Jiwei Yao,et al.  Heme Induces IL-1β Secretion Through Activating NLRP3 in Kidney Inflammation , 2014, Cell Biochemistry and Biophysics.

[54]  A. Alayash,et al.  Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. , 2014, Blood.

[55]  Janet S. Lee,et al.  Mechanisms of hemolysis‐associated platelet activation , 2013, Journal of thrombosis and haemostasis : JTH.

[56]  O. Doumbo,et al.  Haptoglobin phenotype prevalence and cytokine profiles during Plasmodium falciparum infection in Dogon and Fulani ethnic groups living in Mali , 2013, Malaria Journal.

[57]  P. Buehler,et al.  Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity. , 2013, Antioxidants & redox signaling.

[58]  S. Ofori-Acquah,et al.  Extracellular hemin crisis triggers acute chest syndrome in sickle mice. , 2013, The Journal of clinical investigation.

[59]  B. Biemond,et al.  Nucleosomes and neutrophil activation in sickle cell disease painful crisis , 2013, Haematologica.

[60]  M. Hutchinson,et al.  TLR 2 and 4 Responsiveness from Isolated Peripheral Blood Mononuclear Cells from Rats and Humans as Potential Chronic Pain Biomarkers , 2013, PloS one.

[61]  J. Quigley,et al.  The birth, life, and death of red blood cells: Erythropoiesis, the mature red blood cell, and cell destruction , 2013 .

[62]  M. Kaste,et al.  Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events. , 2013, Atherosclerosis.

[63]  M. Saleh,et al.  Functions of NOD-Like Receptors in Human Diseases , 2013, Front. Immunol..

[64]  D. Simone,et al.  Mast cell activation contributes to sickle cell pathobiology and pain in mice. , 2013, Blood.

[65]  G. Núñez,et al.  K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.

[66]  G. Vercellotti,et al.  Vasculotoxic and Proinflammatory Effects of Plasma Heme: Cell Signaling and Cytoprotective Responses , 2013, ISRN oxidative medicine.

[67]  P. Buehler,et al.  Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies. , 2013, Cold Spring Harbor perspectives in medicine.

[68]  J. Boyle,et al.  Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+ Macrophages , 2013, International journal of inflammation.

[69]  K. Su,et al.  Neutrophil Extracellular Traps and Systemic Lupus Erythematosus. , 2013, Journal of clinical & cellular immunology.

[70]  M. Yenari,et al.  The immune modulating properties of the heat shock proteins after brain injury , 2013, Anatomy & cell biology.

[71]  P. Buehler,et al.  Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. , 2013, Blood.

[72]  C. Carmona-Rivera,et al.  Neutrophil Extracellular Trap–Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages , 2013, The Journal of Immunology.

[73]  Samin K. Sharma,et al.  Genotype-Dependent Impairment of Hemoglobin Clearance Increases Oxidative and Inflammatory Response in Human Diabetic Atherosclerosis , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[74]  M. L. Ellsworth,et al.  Erythrocyte‐derived ATP and Perfusion Distribution: Role of Intracellular and Intercellular Communication , 2012, Microcirculation.

[75]  A. Taher,et al.  β-thalassemia intermedia: a clinical perspective. , 2012, Cold Spring Harbor perspectives in medicine.

[76]  M. Daemen,et al.  Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis , 2012, Circulation.

[77]  S. Mousa,et al.  Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell Disease , 2012, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[78]  Moshe Arditi,et al.  Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. , 2012, Immunity.

[79]  D. Golenbock,et al.  Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. , 2012, Blood.

[80]  Qing-Wu Yang,et al.  Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage , 2012, Journal of Neuroinflammation.

[81]  J. Hartwig,et al.  Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. , 2011, Blood.

[82]  P. Evans,et al.  Heme Induces Heme Oxygenase 1 via Nrf2: Role in the Homeostatic Macrophage Response to Intraplaque Hemorrhage , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[83]  D. Webb,et al.  Cyclophilin A Is a Damage-Associated Molecular Pattern Molecule That Mediates Acetaminophen-Induced Liver Injury , 2011, The Journal of Immunology.

[84]  Jie-Oh Lee,et al.  Structural biology of the Toll-like receptor family. , 2011, Annual review of biochemistry.

[85]  B. Biemond,et al.  Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management , 2011, American journal of hematology.

[86]  M. Bours,et al.  P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. , 2011, Frontiers in bioscience.

[87]  A. Dunne Inflammasome activation: from inflammatory disease to infection. , 2011, Biochemical Society transactions.

[88]  J. Tschopp,et al.  A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.

[89]  C. Engwerda,et al.  TNF family members and malaria: old observations, new insights and future directions. , 2010, Experimental parasitology.

[90]  U. Lopes,et al.  Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation* , 2010, The Journal of Biological Chemistry.

[91]  A. Chakrabarti,et al.  Differential regulation of redox proteins and chaperones in HbEβ‐thalassemia erythrocyte proteome , 2010, Proteomics. Clinical applications.

[92]  Z. Prohászka,et al.  Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies , 2010, Cell Stress and Chaperones.

[93]  Weishuang Xue,et al.  Activation of TLR4-Mediated NFκB Signaling in Hemorrhagic Brain in Rats , 2010, Mediators of inflammation.

[94]  W. Junger,et al.  Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury , 2009, Nature.

[95]  F. Costa,et al.  Hemoglobin disorders and endothelial cell interactions. , 2009, Clinical biochemistry.

[96]  G. Vercellotti,et al.  A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsis. , 2009, Cardiovascular & hematological disorders drug targets.

[97]  R. Marée,et al.  P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation , 2009 .

[98]  M. Mota,et al.  Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease. , 2009, The international journal of biochemistry & cell biology.

[99]  S. Saad,et al.  Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy , 2009, Journal of leukocyte biology.

[100]  F. Costa,et al.  Newer Aspects of the Pathophysiology of Sickle Cell Disease Vaso-Occlusion , 2009, Hemoglobin.

[101]  S. G. Betal,et al.  Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia , 2008, Journal of thrombosis and haemostasis : JTH.

[102]  S. Perrotta,et al.  Hereditary spherocytosis , 2008, The Lancet.

[103]  I. Quaye Haptoglobin, inflammation and disease. , 2008, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[104]  M. Olsson,et al.  The lipocalin α1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species , 2008, Free radical research.

[105]  R. Sprague,et al.  Red not dead: signaling in and from erythrocytes , 2007, Trends in Endocrinology & Metabolism.

[106]  Tatiana P. Dutra,et al.  Heme Induces Neutrophil Migration and Reactive Oxygen Species Generation through Signaling Pathways Characteristic of Chemotactic Receptors* , 2007, Journal of Biological Chemistry.

[107]  R. Figueiredo,et al.  Characterization of Heme as Activator of Toll-like Receptor 4* , 2007, Journal of Biological Chemistry.

[108]  V. Fuster,et al.  Downregulation of the Hemoglobin Scavenger Receptor in Individuals With Diabetes and the Hp 2-2 Genotype: Implications for the Response to Intraplaque Hemorrhage and Plaque Vulnerability , 2007, Circulation research.

[109]  A. Prentice,et al.  The haptoglobin 2-2 genotype is associated with a reduced incidence of Plasmodium falciparum malaria in children on the coast of Kenya. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[110]  Charles W Buffington,et al.  Human plasma ATP concentration. , 2007, Clinical chemistry.

[111]  V. Wahn,et al.  Novel cell death program leads to neutrophil extracellular traps. , 2007, The Journal of cell biology.

[112]  M. Mann,et al.  In-depth analysis of the membrane and cytosolic proteome of red blood cells. , 2006, Blood.

[113]  Arturo Zychlinsky,et al.  An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps , 2006, Current Biology.

[114]  Mark T Gladwin,et al.  Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. , 2005, Blood.

[115]  C. Stefanadis,et al.  Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major. , 2005, International journal of cardiology.

[116]  K. Ahn,et al.  Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages. , 2005, Clinical immunology.

[117]  E. Dietz,et al.  Short Communication: Limited influence of haptoglobin genotypes on severe malaria in Ghanaian children , 2005, Tropical medicine & international health : TM & IH.

[118]  M. Gladwin,et al.  The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. , 2005, JAMA.

[119]  M. Yoder,et al.  Sickle cell vaso‐occlusive crisis induces the release of circulating serum heat shock protein‐70 , 2005, American journal of hematology.

[120]  P. Mosci,et al.  TLRs Govern Neutrophil Activity in Aspergillosis1 , 2004, The Journal of Immunology.

[121]  A. Pathare,et al.  Cytokine profile of sickle cell disease in Oman , 2004, American journal of hematology.

[122]  R. Nagel,et al.  Sickle-cell disease , 2004, The Lancet.

[123]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[124]  L. Bulla,et al.  The Human Erythrocyte Proteome , 2004, Molecular & Cellular Proteomics.

[125]  M. Gladwin,et al.  The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. , 2004, Free radical biology & medicine.

[126]  M. Gladwin,et al.  Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation , 2003, Nature Medicine.

[127]  A. Roguin,et al.  Haptoglobin type and 30-day mortality in diabetic individuals presenting with acute myocardial infarction. , 2003, Diabetes care.

[128]  Carl G. Figdor,et al.  Different Faces of the Heme-Heme Oxygenase System in Inflammation , 2003, Pharmacological Reviews.

[129]  M. Gladwin,et al.  Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. , 2002 .

[130]  J. Eaton,et al.  Pro-oxidant and cytotoxic effects of circulating heme. , 2002, Blood.

[131]  F. Martinon,et al.  The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. , 2002, Molecular cell.

[132]  P. Oliveira,et al.  Neutrophil activation by heme: implications for inflammatory processes. , 2002, Blood.

[133]  F. Altruda,et al.  Hemopexin: structure, function, and regulation. , 2002, DNA and cell biology.

[134]  Beverly H. Koller,et al.  Altered Cytokine Production in Mice Lacking P2X7Receptors* , 2001, The Journal of Biological Chemistry.

[135]  N. Ankrah,et al.  Haptoglobin 1-1 is associated with susceptibility to severe Plasmodium falciparum malaria. , 2000, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[136]  Y. Itoyama,et al.  Protective effects of heme oxygenase-1 against oxidant-induced injury in the cultured human tracheal epithelium. , 1999, American journal of respiratory cell and molecular biology.

[137]  K. Bourantas,et al.  Acute phase proteins and interleukins in steady state sickle cell disease , 1998, European journal of haematology.

[138]  H. Bang,et al.  Elevated Serum Cyclophilin Levels in Patients with Severe Sepsis , 1997, Journal of Clinical Immunology.

[139]  I. T. Demchenko,et al.  Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. , 1997, Science.

[140]  A. Rot,et al.  Presence of Cyclophilin A in Synovial Fluids of Patients with Rheumatoid Arthritis , 1997, The Journal of experimental medicine.

[141]  Ann Smith,et al.  Heme‐mediated reactive oxygen species toxicity to retinal pigment epithelial cells is reduced by hemopexin , 1996, Journal of cellular physiology.

[142]  J. Celis,et al.  Identification of two molecular chaperons (HSX70, HSC70) in mature human erythrocytes. , 1991, Experimental cell research.

[143]  W. Engel,et al.  Hemopexin metabolism in patients with altered serum levels. , 1983, The Journal of laboratory and clinical medicine.

[144]  U. Muller-eberhard,et al.  Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. , 1968, Blood.

[145]  G. Kato,et al.  Inflammation and sickle cell anemia , 2016 .

[146]  M. Steinberg Overview of Sickle Cell Anemia Pathophysiology , 2016 .

[147]  C. Svensson,et al.  Role of extracellular damage-associated molecular pattern molecules (DAMPs) as mediators of persistent pain. , 2015, Progress in molecular biology and translational science.

[148]  N. Juffermans,et al.  Pathogenesis of non-antibody mediated transfusion-related acute lung injury from bench to bedside. , 2015, Blood reviews.

[149]  D. Pennington,et al.  Cytokines and chemokines : At the crossroads of cell signalling and in fl ammatory disease , 2014 .

[150]  K. Saigo,et al.  Morphological and flow-cytometric analysis of haemin-induced human neutrophil activation: implications for transfusion-related acute lung injury. , 2013, Blood transfusion = Trasfusione del sangue.

[151]  E. Lima,et al.  Oxidative stress in sickle cell disease , 2013, Revista brasileira de hematologia e hemoterapia.

[152]  J. Stockman Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids , 2012 .

[153]  Yang Xia,et al.  Detrimental effects of adenosine signaling in sickle cell disease , 2011, Nature Medicine.

[154]  N. Beck Anemia: General Considerations , 2009 .

[155]  D. Weatherall,et al.  Disorders of Hemoglobin , 2009 .

[156]  M. Steinberg,et al.  Disorders of Hemoglobin: Clinical and Pathophysiological Aspects of Sickle Cell Anemia , 2009 .

[157]  S. Mariathasan,et al.  Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation , 2007, Nature Reviews Immunology.

[158]  M. Gladwin,et al.  Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. , 2007, Blood reviews.

[159]  J. Zwicker,et al.  Wintrobe's Clinical Hematology , 2005 .

[160]  R. Nagel,et al.  Sickle-cell disease. , 2004, Lancet.

[161]  Rm,et al.  Sickle cell disease , 1996 .

[162]  Y. Yawata [Hemolytic anemia]. , 1994, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.