Premature ovarian failure

Premature ovarian failure (POF) is the occurrence of amenorrhoea, elevated gonadotrophins and hypoestrogenism in women under 40 years of age. It has important physical and psychological consequences and is increasingly common due to improved survival following treatment for malignancy. Despite this, it remains a poorly understood condition. Here we review the presentation and investigation of POF, discuss recent advances in the management of affected women, and suggest how our knowledge of the condition could be improved.

[1]  L. Nelson,et al.  The time is now for a new approach to primary ovarian insufficiency. , 2011, Fertility and sterility.

[2]  G. Wert,et al.  Session 01: Keynote Lectures Session , 2010 .

[3]  J. Grifo,et al.  Oocyte cryopreservation: a feasible fertility preservation option for reproductive age cancer survivors , 2010, Journal of Assisted Reproduction and Genetics.

[4]  J. Rymer,et al.  Treatment of premature ovarian failure trial: description of an ongoing clinical trial , 2010, Menopause international.

[5]  A. Esteghamati,et al.  Menopause is an independent predictor of metabolic syndrome in Iranian women. , 2010, Maturitas.

[6]  J. Troendle,et al.  Bone mineral density in estrogen-deficient young women. , 2009, The Journal of clinical endocrinology and metabolism.

[7]  V. Goossens,et al.  Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). , 2009, Human reproduction.

[8]  D. Green,et al.  Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  L. Mamas,et al.  Premature ovarian failure and dehydroepiandrosterone. , 2009, Fertility and sterility.

[10]  M. Yosef,et al.  Anti-mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition. , 2008, The Journal of clinical endocrinology and metabolism.

[11]  M. Eijkemans,et al.  Lipid profile of women with premature ovarian failure , 2008, Menopause.

[12]  C. Welt,et al.  Primary ovarian insufficiency: a more accurate term for premature ovarian failure , 2008, Clinical endocrinology.

[13]  L. Melton,et al.  Increased risk of parkinsonism in women who underwent oophorectomy before menopause , 2008, Neurology.

[14]  C. Lambalk,et al.  Decreased androgen concentrations and diminished general and sexual well-being in women with premature ovarian failure , 2008, Menopause.

[15]  N. Panay,et al.  Spontaneous premature ovarian failure: Management challenges , 2008, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[16]  N. Panay,et al.  Premature ovarian failure: a growing concern , 2008, Climacteric : the journal of the International Menopause Society.

[17]  S. Emiliani,et al.  Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin's disease. , 2007, The oncologist.

[18]  Sue-Kyung Park,et al.  Premenopausal factors influencing premature ovarian failure and early menopause. , 2007, Maturitas.

[19]  L. Melton,et al.  Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause , 2007, Neurology.

[20]  G. De Pergola,et al.  Effects of pretreatment with estrogens on ovarian stimulation with gonadotropins in women with premature ovarian failure: a randomized, placebo-controlled trial. , 2007, Fertility and sterility.

[21]  L. Nelson,et al.  Effects of ovarian failure and X-chromosome deletion on body composition and insulin sensitivity in young women , 2006, Menopause.

[22]  D. Green,et al.  Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. , 2006, Journal of the National Cancer Institute.

[23]  H. Bang,et al.  Efficiency of oocyte cryopreservation: a meta-analysis. , 2006, Fertility and sterility.

[24]  L. Robison,et al.  Acute ovarian failure in the childhood cancer survivor study. , 2006, The Journal of clinical endocrinology and metabolism.

[25]  J. Ross,et al.  Shyness, social anxiety, and impaired self-esteem in Turner syndrome and premature ovarian failure. , 2006, JAMA.

[26]  S. Batıoğlu,et al.  Bone loss in young women with premature ovarian failure , 2005, Archives of Gynecology and Obstetrics.

[27]  A. Verbeek,et al.  Age at Menopause, Cause-Specific Mortality and Total Life Expectancy , 2005, Epidemiology.

[28]  A. Graziottin,et al.  Sexual dysfunction in women with premature menopause , 2004, Menopause.

[29]  J. Donnez,et al.  Livebirth after orthotopic transplantation of cryopreserved ovarian tissue , 2004, The Lancet.

[30]  G. Chrousos,et al.  Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. , 2004, The Journal of clinical endocrinology and metabolism.

[31]  A. Hofman,et al.  Risk Factors for Incident Vertebral Fractures in Men and Women: The Rotterdam Study , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  H. Taylor,et al.  Elevated basal FSH in normal cycling women is associated with unfavourable lipid levels and increased cardiovascular risk. , 2003, Human reproduction.

[33]  Ivar Heuch,et al.  Age at natural menopause and all-cause mortality: a 37-year follow-up of 19,731 Norwegian women. , 2003, American journal of epidemiology.

[34]  D. V. D. Voort,et al.  Early menopause: increased fracture risk at older age , 2003, Osteoporosis International.

[35]  L. Nelson,et al.  Ovarian antibodies as detected by indirect immunofluorescence are unreliable in the diagnosis of autoimmune premature ovarian failure: a controlled evaluation , 2003, BMC women's health.

[36]  M. Sowers,et al.  Premature menopause in a multi-ethnic population study of the menopause transition. , 2003, Human reproduction.

[37]  D. Schlessinger,et al.  Genes and translocations involved in POF. , 2002, American journal of medical genetics.

[38]  Charles Kooperberg,et al.  Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. , 2002, JAMA.

[39]  L. Nelson,et al.  Meeting the Needs of Young Women With Secondary Amenorrhea and Spontaneous Premature Ovarian Failure , 2002, Obstetrics and gynecology.

[40]  G. Conway,et al.  Premature menopause and psychological well-being , 2000, Journal of psychosomatic obstetrics and gynaecology.

[41]  J. Schoemaker,et al.  Premature ovarian failure: a systematic review on therapeutic interventions to restore ovarian function and achieve pregnancy. , 1999, Human reproduction update.

[42]  B. Jacobsen,et al.  Age at natural menopause and total mortality and mortality from ischemic heart disease: the Adventist Health Study. , 1999, Journal of clinical epidemiology.

[43]  G. Cooper,et al.  Age at natural menopause and mortality. , 1998, Annals of epidemiology.

[44]  L. Nelson,et al.  Bone Loss in Young Women With Karyotypically Normal Spontaneous Premature Ovarian Failure , 1998, Obstetrics and gynecology.

[45]  R. M. Martin-Du Pan.  [Premature menopause]. , 1993, Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.

[46]  Rw Rebar,et al.  Clinical features of young women with hypergonadotropic amenorrhea. , 1990, Fertility and sterility.

[47]  J. Annegers,et al.  Incidence of Premature Ovarian Failure , 1986, Obstetrics and gynecology.

[48]  R. Rebar,et al.  Idiopathic premature ovarian failure: clinical and endocrine characteristics. , 1982, Fertility and sterility.

[49]  J. Morrison,et al.  Mumps oophoritis: a cause of premature menopause. , 1975, Fertility and sterility.