Biotech nanocellulose: A review on progress in product design and today's state of technical and medical applications.

Biotech nanocellulose (bacterial nanocellulose, BNC) is a high potential natural polymer. Moreover, it is the only cellulose type that can be produced biotechnologically using microorganisms resulting in hydrogels with high purity, high mechanical strength and an interconnecting micropore system. Recently, the subject of intensive research is to influence this biosynthesis to create function-determining properties. This review reports on the progress in product design and today's state of technical and medical applications. A novel, dynamic, template-based technology, called Mobile Matrix Reservoir Technology (MMR Tech), is highlighted. Thereby, shape, dimensions, surface properties, and nanonetwork structures can be designed in a process-controlled manner. The formed multilayer materials open up new applications in medicine and technology. Especially medical materials for cardiovascular and visceral surgery, and drug delivery systems are developed. The effective production of layer-structured composites and coatings are important for potential applications in the electronics, paper, food and packaging technologies.

[1]  Wei Huang,et al.  A Novel Multilayer Composite Membrane for Wound Healing in Mice Skin Defect Model , 2020, Polymers.

[2]  Thorsten Wahlers,et al.  Patency and in vivo compatibility of bacterial nanocellulose grafts as small‐diameter vascular substitute , 2017, Journal of vascular surgery.

[3]  Patricia Cerrutti,et al.  Impact of Bacterial Nanocellulose on the Rheological and Textural Characteristics of Low-Lipid Meat Emulsions , 2017 .

[4]  D. Fischer,et al.  Controlled extended octenidine release from a bacterial nanocellulose/Poloxamer hybrid system , 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[5]  A. Califano,et al.  Effect of bacterial nanocellulose addition on the rheological properties of gluten-free muffin batters , 2020 .

[6]  L. Kamolz,et al.  Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine. , 2020, Burns : journal of the International Society for Burn Injuries.

[7]  Z. N. Skvortsova,et al.  Physicochemical Mechanics of Bacterial Cellulose , 2019, Colloid Journal.

[8]  P. Supaphol,et al.  Development of bacterial cellulose/alginate/chitosan composites incorporating copper (II) sulfate as an antibacterial wound dressing , 2019, Journal of Drug Delivery Science and Technology.

[9]  Rainer Erdmann,et al.  White biotechnology for cellulose manufacturing—The HoLiR concept , 2009, Biotechnology and bioengineering.

[10]  E V Liyaskina,et al.  Nanomaterials from bacterial cellulose for antimicrobial wound dressing , 2017 .

[11]  Armando J D Silvestre,et al.  Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies. , 2012, International journal of pharmaceutics.

[12]  Hamed Golmohammadi,et al.  Easy Diagnosis of Jaundice: A Smartphone-Based Nanosensor Bioplatform Using Photoluminescent Bacterial Nanopaper for Point-of-Care Diagnosis of Hyperbilirubinemia. , 2019, ACS sensors.

[13]  Jarno Salonen,et al.  Fabrication, characterization and evaluation of bacterial cellulose-based capsule shells for oral drug delivery , 2017, Cellulose.

[14]  Dieter Klemm,et al.  Nanocelluloses: a new family of nature-based materials. , 2011, Angewandte Chemie.

[15]  Guillermo R. Castro,et al.  Self-Assembly Stereo-Specific Synthesis of Silver Phosphate Microparticles on Bacterial Cellulose Membrane Surface For Antimicrobial Applications , 2018, Colloid and Interface Science Communications.

[16]  Fanglian Yao,et al.  Step-by-step self-assembly of 2D few-layer reduced graphene oxide into 3D architecture of bacterial cellulose for a robust, ultralight, and recyclable all-carbon absorbent , 2018, Carbon.

[17]  Cristiane S. Farinas,et al.  Bacterial Cellulose as a Raw Material for Food and Food Packaging Applications , 2019, Front. Sustain. Food Syst..

[18]  Yan Guo,et al.  Nano-bacterial cellulose/soy protein isolate complex gel as fat substitutes in ice cream model. , 2018, Carbohydrate polymers.

[19]  Chi-Fai Chau,et al.  Investigation on the lipid- and cholesterol-lowering abilities of biocellulose. , 2008, Journal of agricultural and food chemistry.

[20]  Y. Ho,et al.  Drug release and antioxidant/antibacterial activities of silymarin-zein nanoparticle/bacterial cellulose nanofiber composite films. , 2018, Carbohydrate polymers.

[21]  C. Jantarat,et al.  Effect of Piperine on Skin Permeation of Curcumin from a Bacterially Derived Cellulose-Composite Double-Layer Membrane for Transdermal Curcumin Delivery. , 2018, Scientia pharmaceutica.

[22]  Hiroshi Uyama,et al.  Hierarchical porous carbons from a sodium alginate/bacterial cellulose composite for high-performance supercapacitor electrodes , 2018, Applied Surface Science.

[23]  Thorsten Wahlers,et al.  Artificial vascular implants from bacterial cellulose: preliminary results of small arterial substitutes , 2009 .

[24]  Aloña Retegi,et al.  Stiff all-bacterial cellulose nanopaper with enhanced mechanical and barrier properties , 2019, Materials Letters.

[25]  Xingbin Yang,et al.  Enhanced anti-obesity effects of bacterial cellulose combined with konjac glucomannan in high-fat diet-fed C57BL/6J mice. , 2018, Food & function.

[26]  Qufu Wei,et al.  A highly flexible self-powered biosensor for glucose detection by epitaxial deposition of gold nanoparticles on conductive bacterial cellulose , 2018, Chemical Engineering Journal.

[27]  Hao Zhuo,et al.  Compressible, Elastic, and Pressure-Sensitive Carbon Aerogels Derived from 2D Titanium Carbide Nanosheets and Bacterial Cellulose for Wearable Sensors , 2019, Chemistry of Materials.

[28]  Zhong Jie Zhang,et al.  Carbon nanofibers derived from bacterial cellulose: Surface modification by polydopamine and the use of ferrous ion as electrolyte additive for collaboratively increasing the supercapacitor performance , 2020 .

[29]  Frank A. Müller,et al.  Bacterial nanocellulose with a shape-memory effect as potential drug delivery system , 2014 .

[30]  S. Ummartyotin,et al.  Synthesis and characterization of bacterial cellulose and gelatin-based hydrogel composites for drug-delivery systems , 2017, Biotechnology reports.

[31]  Carmen S. R. Freire,et al.  Bacterial cellulose membranes as transdermal delivery systems for diclofenac: in vitro dissolution and permeation studies. , 2014, Carbohydrate polymers.

[32]  Yong Wang,et al.  Freestanding carbon aerogels produced from bacterial cellulose and its Ni/MnO2/Ni(OH)2 decoration for supercapacitor electrodes , 2018, Journal of Applied Electrochemistry.

[33]  M. Skočaj,et al.  Bacterial nanocellulose in papermaking , 2019, Cellulose.

[34]  Marco Andrey Cipriani Frade,et al.  Development, characterization and pre-clinical trials of an innovative wound healing dressing based on propolis (EPP-AF®)-containing self-microemulsifying formulation incorporated in biocellulose membranes. , 2019, International journal of biological macromolecules.

[35]  Antje Potthast,et al.  Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate. , 2020, Materials science & engineering. C, Materials for biological applications.

[36]  Li Yan,et al.  Naturally-Occurring Bacterial Cellulose-Hyperbranched Cationic Polysaccharide Derivative/MMP-9 siRNA Composite Dressing for Wound Healing Enhancement in Diabetic Rats. , 2019, Acta biomaterialia.

[37]  Carmen S. R. Freire,et al.  Design of Nonsteroidal Anti-Inflammatory Drug-Based Ionic Liquids with Improved Water Solubility and Drug Delivery , 2019, ACS Sustainable Chemistry & Engineering.

[38]  Michael J. Gidley,et al.  Mechanical properties of bacterial cellulose synthesised by diverse strains of the genus Komagataeibacter , 2018, Food Hydrocolloids.

[39]  Ki-Bong Kim,et al.  Saphenous vein grafts in contemporary coronary artery bypass graft surgery , 2019, Nature Reviews Cardiology.

[40]  E. Kovacs,et al.  Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. , 2005, American journal of physiology. Heart and circulatory physiology.

[41]  Jian Hu,et al.  Layer-by-Layer Assembled Bacterial Cellulose/Graphene Oxide Hydrogels with Extremely Enhanced Mechanical Properties , 2018, Nano-Micro Letters.

[42]  H. Gibson,et al.  Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings , 2019, European Polymer Journal.

[43]  Mehran Moradi,et al.  A novel pH-sensing indicator based on bacterial cellulose nanofibers and black carrot anthocyanins for monitoring fish freshness. , 2019, Carbohydrate polymers.

[44]  Sandor Nietzsche,et al.  In vitro hemo- and cytocompatibility of bacterial nanocelluose small diameter vascular grafts: Impact of fabrication and surface characteristics. , 2020, PloS one.

[45]  F. Müller,et al.  Antimicrobial functionalization of bacterial nanocellulose by loading with polihexanide and povidone-iodine , 2015, Journal of Materials Science: Materials in Medicine.

[46]  P. Echlin Handbook of Sample Preparation for Scanning Electron Microscopy and X-Ray Microanalysis , 2009 .

[47]  Xingbin Yang,et al.  Bacterial cellulose in food industry: Current research and future prospects. , 2020, International journal of biological macromolecules.

[48]  Sandor Nietzsche,et al.  Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state , 2018, Materials Today.

[49]  Fernando Dourado,et al.  A Review on the toxicology and dietetic role of bacterial cellulose , 2017, Toxicology reports.

[50]  Guang Yang,et al.  Nano-cellulose 3D-networks as controlled-release drug carriers. , 2013, Journal of materials chemistry. B.

[51]  Dolores Corella,et al.  Dietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease. , 2015, The American journal of clinical nutrition.

[52]  Yang Wang,et al.  Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with β-cyclodextrin for potential anti-infection oral administration. , 2020, International journal of biological macromolecules.

[53]  Min Zhao,et al.  Flexible electrically conductive biomass-based aerogels for piezoresistive pressure/strain sensors , 2019, Chemical Engineering Journal.

[54]  Dieter Klemm,et al.  Polyelectrolyte layer assembly of bacterial nanocellulose whiskers with plasmid DNA as biocompatible non-viral gene delivery system , 2018, Cellulose.

[55]  Dana Kralisch,et al.  Immobilization of plasmids in bacterial nanocellulose as gene activated matrix. , 2019, Carbohydrate polymers.

[56]  Taous Khan,et al.  Surface modification and evaluation of bacterial cellulose for drug delivery. , 2018, International journal of biological macromolecules.

[57]  Guang Yang,et al.  Green synthesis of silver nanoparticles impregnated bacterial cellulose-alginate composite film with improved properties , 2017 .

[58]  Mehran Moradi,et al.  Design and preparation of antimicrobial meat wrapping nanopaper with bacterial cellulose and postbiotics of lactic acid bacteria. , 2020, International journal of food microbiology.

[59]  Sajad Pirsa,et al.  Development of bacterial cellulose based slow-release active films by incorporation of Scrophularia striata Boiss. extract. , 2017, Carbohydrate polymers.

[60]  Y. Nishi,et al.  The structure and mechanical properties of sheets prepared from bacterial cellulose , 1990 .

[61]  Wei Shao,et al.  Controlled release and antibacterial activity of tetracycline hydrochloride-loaded bacterial cellulose composite membranes. , 2016, Carbohydrate polymers.

[62]  A. Stoica-Guzun,et al.  Controlled release of sorbic acid from bacterial cellulose based mono and multilayer antimicrobial films , 2012 .

[63]  Zhiwei Yang,et al.  Uniformly Dispersed Freestanding Carbon Nanofiber/Graphene Electrodes Made by a Scalable Biological Method for High‐Performance Flexible Supercapacitors , 2018, Advanced Functional Materials.

[64]  Junkal Gutierrez,et al.  Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties. , 2018, Carbohydrate polymers.

[65]  Fernando Dourado,et al.  Molecular aspects of bacterial nanocellulose biosynthesis , 2019, Microbial biotechnology.

[66]  Feng F. Hong,et al.  Preparation and evaluation of a kind of bacterial cellulose dry films with antibacterial properties , 2011 .

[67]  Nabanita Saha,et al.  Bacterial cellulose and guar gum based modified PVP-CMC hydrogel films: Characterized for packaging fresh berries , 2019 .

[68]  Roberto Pontarolo,et al.  Lysozyme-triggered epidermal growth factor release from bacterial cellulose membranes controlled by smart nanostructured films. , 2014, Journal of pharmaceutical sciences.

[69]  Shivakalyani Adepu,et al.  Bacterial cellulose with microencapsulated antifungal essential oils: Novel double barrier release system , 2020, Materialia.

[70]  Dana Kralisch,et al.  The biopolymer bacterial nanocellulose as drug delivery system: investigation of drug loading and release using the model protein albumin. , 2013, Journal of pharmaceutical sciences.

[71]  Yang Liu,et al.  Graphene/Carbon Nanotube/Bacterial Cellulose assisted supporting for polypyrrole towards flexible supercapacitor applications , 2019, Journal of Alloys and Compounds.

[72]  Gabriela Isopencu,et al.  Antimicrobial Food Pads Containing Bacterial Cellulose and Polysaccharides , 2019, Polymers and Polymeric Composites: A Reference Series.

[73]  Y. Nishi,et al.  The structure and mechanical properties of sheets prepared from bacterial cellulose , 1989 .

[74]  F. Müller,et al.  Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. , 2014, International journal of pharmaceutics.

[75]  Redouane Borsali,et al.  A slow-release system of bacterial cellulose gel and nanoparticles for hydrophobic active ingredients. , 2015, International journal of pharmaceutics.

[76]  Jeffrey M. Ting,et al.  Advances in Polymer Design for Enhancing Oral Drug Solubility and Delivery. , 2018, Bioconjugate chemistry.

[77]  Oliver Werz,et al.  Development and Characterization of Bacterial Nanocellulose Loaded with Boswellia Serrata Extract Containing Nanoemulsions as Natural Dressing for Skin Diseases. , 2020, International journal of pharmaceutics.

[78]  Peter Weyell,et al.  Tailor-made material characteristics of bacterial cellulose for drug delivery applications in dentistry. , 2019, Carbohydrate polymers.

[79]  A. Stoica-Guzun,et al.  Vanillin release from poly(vinyl alcohol)-bacterial cellulose mono and multilayer films , 2013 .

[80]  Dieter Klemm,et al.  In vivo application of tissue-engineered blood vessels of bacterial cellulose as small arterial substitutes: proof of concept? , 2014, The Journal of surgical research.

[81]  T. Dobre,et al.  Composite films of poly(vinyl alcohol)-chitosan-bacterial cellulose for drug controlled release. , 2014, International journal of biological macromolecules.

[82]  Carmen S. R. Freire,et al.  Preparation and characterization of bacterial cellulose membranes with tailored surface and barrier properties , 2010 .

[83]  J. Catchmark,et al.  Mechanical and structural property analysis of bacterial cellulose composites. , 2016, Carbohydrate polymers.

[84]  Guillermo R. Castro,et al.  Hybrid bacterial cellulose–pectin films for delivery of bioactive molecules , 2018 .

[85]  Michael Hornung,et al.  Optimizing the Production of Bacterial Cellulose in Surface Culture: A Novel Aerosol Bioreactor Working on a Fed Batch Principle (Part 3) , 2007 .

[86]  Koichi Enomoto,et al.  Increased Antibiotic Release from a Bone Cement Containing Bacterial Cellulose , 2011, Clinical orthopaedics and related research.

[87]  A. M. Gerrard,et al.  Optimizing the Production of Bacterial Cellulose in Surface Culture: Evaluation of Substrate Mass Transfer Influences on the Bioreaction (Part 1) , 2006 .

[88]  Inder M. Saxena and R. Malcolm Brown,et al.  Biosynthesis of Bacterial Cellulose , 2016 .

[89]  M. Winter,et al.  What are batteries, fuel cells, and supercapacitors? , 2004, Chemical reviews.

[90]  Leonardo Pereira Franchi,et al.  Toxicity of therapeutic contact lenses based on bacterial cellulose with coatings to provide transparency. , 2019, Contact lens & anterior eye : the journal of the British Contact Lens Association.

[91]  G. R. Castro,et al.  Modified bacterial cellulose scaffolds for localized doxorubicin release in human colorectal HT-29 cells. , 2016, Colloids and surfaces. B, Biointerfaces.

[92]  R Panchagnula,et al.  Alteration of skin hydration and its barrier function by vehicle and permeation enhancers: a study using TGA, FTIR, TEWL and drug permeation as markers. , 2008, Methods and findings in experimental and clinical pharmacology.

[93]  Wei Shao,et al.  Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation. , 2018, ACS applied materials & interfaces.

[94]  Carmen S. R. Freire,et al.  Topical caffeine delivery using biocellulose membranes: a potential innovative system for cellulite treatment , 2014, Cellulose.

[95]  Vahabodin Goodarzi,et al.  Challenge between sequence presences of conductive additives on flexibility, dielectric and supercapacitance behaviors of nanofibrillated template of bacterial cellulose aerogels , 2019, European Polymer Journal.

[96]  Yi Zhang,et al.  Bacterial cellulose based composites enhanced transdermal drug targeting for breast cancer treatment , 2019, Chemical Engineering Journal.

[97]  N. Laçin,et al.  Development of biodegradable antibacterial cellulose based hydrogel membranes for wound healing. , 2014, International journal of biological macromolecules.

[98]  Stefan Lorkowski,et al.  Process control and scale-up of modified bacterial cellulose production for tailor-made anti-inflammatory drug delivery systems. , 2020, Carbohydrate polymers.

[99]  V. Revin,et al.  Bacterial Cellulose/Alginate Nanocomposite for Antimicrobial Wound Dressing , 2018 .

[100]  Emanuel Carrilho,et al.  Bacterial cellulose-based electrochemical sensing platform: A smart material for miniaturized biosensors , 2020 .

[101]  Raimund Jaeger,et al.  Laser-structured bacterial nanocellulose hydrogels support ingrowth and differentiation of chondrocytes and show potential as cartilage implants. , 2014, Acta biomaterialia.

[102]  Taous Khan,et al.  Functionalized Bacterial Cellulose Microparticles for Drug Delivery in Biomedical Applications. , 2019, Current pharmaceutical design.

[103]  Xinhua Xu,et al.  Exploring excellent dispersion of graphene nanosheets in three-dimensional bacterial cellulose for ultra-strong nanocomposite hydrogels , 2018, Composites Part A: Applied Science and Manufacturing.