论文信息 - Serial SimCoal: A population genetics model for data from multiple populations and points in time

Serial SimCoal: A population genetics model for data from multiple populations and points in time

UNLABELLED We present Serial SimCoal, a program that models population genetic data from multiple time points, as with ancient DNA data. An extension of SIMCOAL, it also allows simultaneous modeling of complex demographic histories, and migration between multiple populations. Further, we incorporate a statistical package to calculate relevant summary statistics, which, for the first time allows users to investigate the statistical power provided by, conduct hypothesis-testing with, and explore sample size limitations of ancient DNA data. AVAILABILITY Source code and Windows/Mac executables at http://www.stanford.edu/group/hadlylab/ssc.html CONTACT senka@stanford.edu.

[1] C. J-F,et al. THE COALESCENT , 1980 .

[2] R. Hudson. Gene genealogies and the coalescent process. , 1990 .

[3] L. Excoffier,et al. SIMCOAL: a general coalescent program for the simulation of molecular data in interconnected populations with arbitrary demography. , 2000, The Journal of heredity.

[4] D. Balding,et al. Approximate Bayesian computation in population genetics. , 2002, Genetics.

[5] Alexei J Drummond,et al. Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data. , 2002, Genetics.

[6] C. Millar,et al. Rates of Evolution in Ancient DNA from Adélie Penguins , 2002, Science.

[7] Uma Ramakrishnan,et al. Genetic Response to Climatic Change: Insights from Ancient DNA and Phylochronology , 2004, PLoS biology.