Weight at first detection of retinopathy of prematurity predicts disease severity

Objective To investigate whether postnatal weight at first detection of retinopathy of prematurity (ROP) can predict preterm infants who will develop severe ROP warranting treatment. Design This modern, population-based cohort included 147 infants born at gestational age (GA) <32 weeks in the Gothenburg region during 2011–2012 and screened for ROP at Sahlgrenska University hospital. GA, birth weight (BW), and weekly postnatal weight from birth until postmenstrual age (PMA) 40 weeks data were retrospectively retrieved. Birth weight SD scores (BWSDS) were calculated. ROP data, including first detected ROP stage, maximal ROP stage, ROP treatment, and PMA at first detected sign of ROP were also retrieved. Weight SDS (WSDS) at first ROP detection was calculated. Results Stepwise multivariate logistic regression analysis revealed that the best fit-model of risk factors for developing severe ROP warranting treatment included; GA (OR=0.28, CI 95% 0.12 to 0.66, p<0.01) and WSDS at first ROP detection (OR=0.22, CI 95% 0.05 to 0.89, p<0.05). Conclusions Low weight and low WSDS at first ROP detection can be useful predictors for ROP warranting treatment.

[1]  Jiayan Huang,et al.  The CHOP postnatal weight gain, birth weight, and gestational age retinopathy of prematurity risk model. , 2012, Archives of ophthalmology.

[2]  M. Maia,et al.  A predictive score for retinopathy of prematurity in very low birth weight preterm infants , 2012, Eye.

[3]  A. Hellström,et al.  Screening for retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden. , 2009, Archives of ophthalmology.

[4]  L. V. Marter.  A Clinical Prediction Model to Stratify Retinopathy of Prematurity Risk Using Postnatal Weight Gain , 2011 .

[5]  A. Hellström,et al.  Natural history of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden. , 2010, Archives of ophthalmology.

[6]  L. Sirota,et al.  Outcome of Early-Onset Sepsis in a National Cohort of Very Low Birth Weight Infants , 2010, Pediatrics.

[7]  Lois E. H. Smith,et al.  Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. , 2009, Archives of ophthalmology.

[8]  Lois E. H. Smith,et al.  Early Weight Gain Predicts Retinopathy in Preterm Infants: New, Simple, Efficient Approach to Screening , 2009, Pediatrics.

[9]  J. Sears,et al.  A change in oxygen supplementation can decrease the incidence of retinopathy of prematurity. , 2009, Ophthalmology.

[10]  G. Holmström,et al.  Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden. , 2009, Archives of ophthalmology.

[11]  R. Procianoy,et al.  Incidence and risk factors for retinopathy of prematurity in very low and in extremely low birth weight infants in a unit-based approach in southern Brazil , 2009, Eye.

[12]  M. Maia,et al.  Weight gain measured at 6 weeks after birth as a predictor for severe retinopathy of prematurity: study with 317 very low birth weight preterm babies , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[13]  A. Fielder,et al.  Lower Stress Responses After Newborn Individualized Developmental Care and Assessment Program Care During Eye Screening Examinations for Retinopathy of Prematurity: A Randomized Study , 2008, Pediatrics.

[14]  C. Schmid,et al.  Cumulative illness severity and progression from moderate to severe retinopathy of prematurity , 2007, Journal of Perinatology.

[15]  J. Folch,et al.  Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity , 2007 .

[16]  E. Donovan,et al.  Race, gender, and clinical risk index for babies (CRIB) score as predictors of severe retinopathy of prematurity. , 2006, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[17]  P. Box.  Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network , 2006 .

[18]  Anna L. Ells,et al.  The International Classification of Retinopathy of Prematurity revisited. , 2005, Archives of ophthalmology.

[19]  N. Evans,et al.  Prenatal Risk Factors for Severe Retinopathy of Prematurity Among Very Preterm Infants of the Australian and New Zealand Neonatal Network , 2005, Pediatrics.

[20]  W. Tasman,et al.  Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. , 2004, Archives of ophthalmology.

[21]  William V Good,et al.  Risk analysis of prethreshold retinopathy of prematurity. , 2003, Archives of ophthalmology.

[22]  A. Fielder,et al.  Preliminary results of treatment of eyes with high-risk prethreshold retinopathy of prematurity in the early treatment for retinopathy of prematurity randomized trial. , 2003, Archives of ophthalmology.

[23]  Lois E. H. Smith,et al.  Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. , 2003, Pediatrics.

[24]  I. Casteels,et al.  Perinatal growth characteristics and associated risk of developing threshold retinopathy of prematurity. , 2003, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus.

[25]  A. Fanaroff,et al.  Outcomes of children of extremely low birthweight and gestational age in the 1990's. , 1999, Early human development.

[26]  A. Selbing,et al.  Intrauterine growth curves based on ultrasonically estimated foetal weights , 1996, Acta paediatrica.

[27]  B. Stevens,et al.  Premature Infant Pain Profile: development and initial validation. , 1996, The Clinical journal of pain.

[28]  B. Peitersen,et al.  Retinopathy of prematurity: review of a seven‐year period in a Danish neonatal intensive care unit , 1994, Acta paediatrica.