Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children

A remarkably high incidence of bronchiectasis and other pulmonary sequelae was observed in young children affected during an epidemic of severe lower respiratory tract infections apparently caused by adenovirus type 21. The histopathological findings are described in four cases in which one or both lungs were obtained for examination at intervals ranging from two months to three years after the acute infections. Widespread bronchiolar obliteration (bronchiolitis obliterans) was a striking finding in all four. The severity of bronchial inflammation and of bronchiectasis was proportional to the time elapsed since the acute infections. Bronchiolar obliteration is a likely sequel of the necrotizing bronchiolitis which may occur during acute adenovirus infections. The role of bronchiolar obliteration in the pathogenesis of bronchiectasis and other chronic lung disease is discussed. Adenoviruses may be a major cause of post-infectious bronchiectasis in childhood.

[1]  J. Steen-johnsen,et al.  SEVERE ILLNESSES DUE TO ADENOVIRUS TYPE 7 IN CHILDREN , 1969, Acta paediatrica Scandinavica.

[2]  J. Burton,et al.  Bronchopneumonia with Serious Sequelae in Children with Evidence of Adenovirus Type 21 Infection , 1969, British medical journal.

[3]  J. Connor,et al.  Neonatal infection caused by adenovirus type 7. , 1968, The Journal of pediatrics.

[4]  W. Dowdle,et al.  A fatal illness associated with two viruses: an intermediate adenovirus type (21-16) and influenza A2. , 1968, The Journal of pediatrics.

[5]  P. Zorab,et al.  The development of unilateral hypertransradiancy of the lung , 1967 .

[6]  J. Guillory,et al.  Fatal nonbacterial pneumonia associated with Adenovirus type 4. Occurrence in an adult. , 1967, JAMA.

[7]  D. Becroft.  Histopathology of fatal adenovirus infection of the respiratory tract in young children , 1967, Journal of clinical pathology.

[8]  J. Connor,et al.  Generalized type 5 adenovirus infection associated with the pertussis syndrome. , 1966, The Journal of pediatrics.

[9]  J. S. St. Geme,et al.  Mixed systemic virus infection: a postulate for alteration of host resistance to adenovirus infection. , 1966, The Journal of pediatrics.

[10]  C. Welch,et al.  INFECTIOUS AGENTS ASSOCIATED WITH CYLINDRICAL BRONCHIECTASIS. , 1964, Diseases of the chest.

[11]  D. Peacock,et al.  Viruses Associated with Acute Respiratory Infections , 1964, British medical journal.

[12]  M. M. Culiner.  OBLITERATIVE BONCHITIS AND BRONCHIOLITIS WITH BRONCHIECTASIS. , 1963, Diseases of the chest.

[13]  Adenovirus Infection in Childhood , 1963 .

[14]  N. S. Clark.  Bronchiectasis in Childhood , 1963, British medical journal.

[15]  J. P. van der Veen,et al.  Association of type 21 adenovirus with acute respiratory illness in military recruits. , 1962, American journal of hygiene.

[16]  R. Beard,et al.  Ice-packs after Episiotomy , 1961 .

[17]  D. Mccomb,et al.  Adenoviruses isolated from Saudi Arabia. III. Six New Serotypes. , 1960 .

[18]  C. Chany,et al.  Severe and fatal pneumonia in infants and young children associated with adenovirus infections. , 1958, American journal of hygiene.

[19]  R. Sommerville,et al.  Non-tuberculous juvenile bronchiectasis: a virus disease? , 1957, Lancet.

[20]  C. Strang.  The fate of children with bronchiectasis. , 1956, Annals of internal medicine.

[21]  D. J. Conway.  Bronchiectasis in Childhood , 1952, Postgraduate medical journal.

[22]  L. Reid.  Reduction in Bronchial Subdivision in Bronchiectasis , 1950, Thorax.

[23]  C. E. Field.  Bronchiectasis in childhood; clinical survey of 160 cases. , 1949, Pediatrics.

[24]  E. Churchill.  The segmental and lobular physiology and pathology of the lung. , 1949, The Journal of thoracic surgery.

[25]  W Fell,et al.  Successful Case of Extirpation of the Kidney for Hydronephrosis , 1888, British medical journal.

[26]  J. Swierenga.  Childhood bronchiectasis. , 1957, Diseases of the Chest.