Determination of chloramphenicol by gas-liquid chromatography.

Convenient gas-liquid chromatographic methods for the analysis of chloramphenicols have been described. A mixture of chloramphenicol and its acetates was completely separated and identified. For estimation, pharmaceuticals or plasma was extracted with appropriate solvent and chromatographed directly without extensive treatment utilizing hydrogen flame or electron capture detector system, respectively. The methods have speed, simplicity, and accuracy.