Comparison of ventilation/perfusion lung-imaging and dead-space measurements in airway disease.

1. Nineteen patients (three normal subjects, at 16 patients with chronic airway disease) were investigated with radionuclide lung-imaging and pulmonary function tests. 2. There was a statistically significant correlation between the ratio of residual volume to total lung capacity and alveolar dead-space ventilation for nitrogen as a percentage of alveolar ventilation (an index of gas mixing inefficiency); rs = 0.54, P less than 0.05. 3. There were statistically significant associations between an abnormal ventilation or perfusion radionuclide lung image and (a) the ratio of residual volume to total lung capacity and (b) the alveolar dead-space ventilation for nitrogen as a percentage of alveolar ventilation. 4. The radionuclide counts from the posterior images were normalized for lung size and injected dose; perfusion counts were then subtracted from ventilation counts at locations from the top to the bottom of the lungs. 5. There was a statistically significant association between low ventilation minus perfusion areas and arterial hypoxia. 6. There was a statistically significant association between high ventilation minus perfusion areas and an increased alveolar dead-space ventilation for carbon dioxide as a percentage of alveolar ventilation.

[1]  M. Goris,et al.  Applications of ventilation lung imaging with 81mKrypton. , 1977, Radiology.

[2]  F. Fazio,et al.  Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m. , 1975, British medical journal.

[3]  D. Croft,et al.  Ventilation-Perfusion Lung Scanning for Pulmonary Emboli , 1974, British medical journal.

[4]  K. Prowse,et al.  Effects of lung volume and disease on the lung nitrogen decay curve. , 1973, Journal of applied physiology.

[5]  J. Hughes,et al.  81mKr generator and its uses in cardiopulmonary studies with the scintillation camera. , 1970, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  H. Wagner,et al.  Radioactive xenon in the differential diagnosis of pulmonary embolism. , 1968, Radiology.

[7]  G. W. Snedecor.  STATISTICAL METHODS , 1967 .

[8]  H. Kaplan,et al.  SUSPENSIONS OF RADIOALBUMIN AGGREGATES FOR PHOTOSCANNING THE LIVER, SPLEEN, LUNG AND OTHER ORGANS. , 1964, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  C. Dollery,et al.  Distribution of gas and blood in the lungs in disease. , 1963, British medical bulletin.

[10]  W. C. Ball,et al.  Regional pulmonary function studied with xenon 133. , 1962, The Journal of clinical investigation.

[11]  R. S. Williams,et al.  Pulmonary ventilation; blood flow relationships in intersititial disease of the lungs. , 1959, The American journal of medicine.

[12]  J. West,et al.  Measurement of the ventilation-perfusion ratio inequality in the lung by the analysis of a single expirate. , 1957, Clinical science.

[13]  J. H. Comroe,et al.  A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. , 1956, The Journal of clinical investigation.

[14]  J. H. Comroe,et al.  A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. , 1956, The Journal of clinical investigation.

[15]  C. D. Needham,et al.  Normal standards for lung volumes, intrapulmonary gas-mixing, and maximum breathing capacity. , 1954, Thorax.

[16]  W. S. Fowler.  Intrapulmonary distribution of inspired gas. , 1952, Physiological reviews.

[17]  R. Riley,et al.  Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs; theory. , 1951, Journal of applied physiology.

[18]  W. S. Fowler.  Lung function studies; uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. , 1949, Journal of applied physiology.

[19]  G. Birath.  Lung Volume and Ventilation Efficiency. Changes in Collapse-treated and Non-Collapsed-treated Pulmonary Tuberculosis and in Pulmonectomy and Lobeetomy. , 1944 .

[20]  A. Cournand,et al.  STUDIES ON INTRAPULMONARY MIXTURE OF GASES. V. FORMS OF INADEQUATE VENTILATION IN NORMAL AND EMPHYSEMATOUS LUNGS, ANALYZED BY MEANS OF BREATHING PURE OXYGEN. , 1944, The Journal of clinical investigation.

[21]  A. E. Clark-Kennedy,et al.  On the fluctuation in the composition of the alveolar air during the respiratory cycle in muscular exercise , 1928, The Journal of physiology.

[22]  A. Krogh,et al.  The volume of the dead space in breathing and the mixing of gases in the lungs of man , 1917, The Journal of physiology.