Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma

The secretory enzyme lysyl oxidase like 2 (LOXL2) is speculated to contribute to tumor progression through its functions in the remodeling of extracellular matrix and epithelial‐mesenchymal transition. We previously identified elevated expression of LOXL2 in metastatic human head and neck squamous cell carcinoma (HNSCC) cells in a mouse lymph node metastases model. Here we performed a case series study examining LOXL2 expression levels in human serum from HNSCC patients to evaluate whether LOXL2 is worth evaluation in a large cohort study.

[1]  Mian-hua Wu,et al.  Exosome-related tumor microenvironment , 2018, Journal of Cancer.

[2]  K. Akiyoshi,et al.  Exosome‐mediated regulation of tumor immunology , 2018, Cancer science.

[3]  J. Hsieh,et al.  Exosomes in cancer development and clinical applications , 2018, Cancer science.

[4]  D. Vertommen,et al.  Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation , 2018, Journal of extracellular vesicles.

[5]  Y. Yamaguchi,et al.  Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases , 2018, International journal of molecular sciences.

[6]  P. Trackman.  Functional importance of lysyl oxidase family propeptide regions , 2018, Journal of Cell Communication and Signaling.

[7]  F. Hochberg,et al.  Extracellular vesicles: the growth as diagnostics and therapeutics; a survey , 2018, Journal of extracellular vesicles.

[8]  C. Cernea,et al.  Risk Factors for Distant Metastasis in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgical Treatment , 2018, ORL.

[9]  S. Sen,et al.  Secretory microRNAs as biomarkers of cancer. , 2017, Seminars in cell & developmental biology.

[10]  Fuquan Zhang,et al.  The value of squamous cell carcinoma antigen (SCCa) to determine the lymph nodal metastasis in cervical cancer: A meta-analysis and literature review , 2017, PloS one.

[11]  A. Llorente,et al.  Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients , 2017, BMC Cancer.

[12]  A. Psyrri,et al.  Liquid biopsy: An emerging prognostic and predictive tool in Head and Neck Squamous Cell Carcinoma (HNSCC). Focus on Circulating Tumor Cells (CTCs). , 2017, Oral oncology.

[13]  Yusuke Yamamoto,et al.  A combination of circulating miRNAs for the early detection of ovarian cancer , 2017, Oncotarget.

[14]  R. Vanacore,et al.  Proteolytic processing of lysyl oxidase–like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV , 2017, The Journal of Biological Chemistry.

[15]  B. O'Sullivan,et al.  Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer. , 2017, Radiotherapy and Oncology.

[16]  Scott M Langevin,et al.  Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers , 2017, Oncotarget.

[17]  Hoguen Kim,et al.  Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis , 2017, Oncotarget.

[18]  K. Shiota,et al.  Elevated Na+/H+ exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells. , 2017, Biochemical and biophysical research communications.

[19]  N. Cloonan,et al.  Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions , 2017, Journal of extracellular vesicles.

[20]  M. Glatzel,et al.  Exosomes and the Prion Protein: More than One Truth , 2017, Front. Neurosci..

[21]  R. Andriantsitohaina,et al.  Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles , 2017, Journal of extracellular vesicles.

[22]  F. Portillo,et al.  LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway , 2017, Scientific Reports.

[23]  I. Vorberg,et al.  Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates , 2017, Prion.

[24]  V. Díaz,et al.  Lysyl oxidase‐like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3 , 2016, The FEBS journal.

[25]  N. Stoecklein,et al.  Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion , 2016, Oncotarget.

[26]  E. Henske,et al.  Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex , 2016, Oncogene.

[27]  Jae Keun Kim,et al.  Emerging role of LOXL2 in the promotion of pancreas cancer metastasis , 2016, Oncotarget.

[28]  E. Li,et al.  A truncated splice variant of human lysyl oxidase-like 2 promotes migration and invasion in esophageal squamous cell carcinoma. , 2016, The international journal of biochemistry & cell biology.

[29]  J. Erler,et al.  Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis. , 2016, Cancer research.

[30]  B. W. van Balkom,et al.  Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up‐regulation of lysyl oxidase‐like 2 , 2015, Journal of cellular and molecular medicine.

[31]  A. G. de Herreros,et al.  LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival , 2015, Clinical Cancer Research.

[32]  S. Peiró,et al.  LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation. , 2015, Molecular cell.

[33]  S. Peiró,et al.  A new role for LOX and LOXL2 proteins in transcription regulation , 2015, The FEBS journal.

[34]  L. O’Driscoll,et al.  Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.

[35]  J. Inal,et al.  Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis , 2015, Journal of extracellular vesicles.

[36]  T. Ronnebaum,et al.  Human lysyl oxidase-like 2. , 2014, Bioorganic chemistry.

[37]  I. Ng,et al.  Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma , 2014, Hepatology.

[38]  E. Li,et al.  Identification of a novel lysyl oxidase-like 2 alternative splicing isoform, LOXL2 Δe13, in esophageal squamous cell carcinoma. , 2014, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[39]  Y. Igarashi,et al.  Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice* , 2014, The Journal of Biological Chemistry.

[40]  Y. Igarashi,et al.  Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease. , 2014, Biochimica et biophysica acta.

[41]  K. Csiszȧr,et al.  Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization , 2014, Oncogene.

[42]  T. Jenuwein,et al.  Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. , 2013, Molecular cell.

[43]  Seung Ah Lee,et al.  LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients , 2013, Breast Cancer Research and Treatment.

[44]  J. Silke,et al.  The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells , 2012, Science Signaling.

[45]  K. Nakashiro,et al.  Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes. , 2012, Oral oncology.

[46]  Thomas R. Cox,et al.  The rationale for targeting the LOX family in cancer , 2012, Nature Reviews Cancer.

[47]  E. Li,et al.  Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. , 2012, Human pathology.

[48]  Y. Igarashi,et al.  Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia , 2012, The Journal of Biological Chemistry.

[49]  R. Schiffelers,et al.  Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes , 2012, Journal of extracellular vesicles.

[50]  K. Eckardt,et al.  The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia , 2009, The Journal of Biological Chemistry.

[51]  Qian Liu,et al.  Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. , 2009, Carcinogenesis.

[52]  J. Erler,et al.  Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. , 2009, Cancer cell.

[53]  F. Portillo,et al.  Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas. , 2008, Cancer research.

[54]  S. Fong,et al.  Lysyl oxidase‐like 2 expression is increased in colon and esophageal tumors and associated with less differentiated colon tumors , 2007, Genes, chromosomes & cancer.

[55]  J. Erler,et al.  Lysyl oxidase mediates hypoxic control of metastasis. , 2006, Cancer research.

[56]  K. Csiszȧr,et al.  A molecular role for lysyl oxidase‐like 2 enzyme in Snail regulation and tumor progression , 2005, The EMBO journal.

[57]  N. Sakuragi,et al.  Preoperative serum SCC, CA125, and CA19‐9 levels and lymph node status in squamous cell carcinoma of the uterine cervix , 2002, Acta obstetricia et gynecologica Scandinavica.

[58]  G. Kenter,et al.  Clinical value of pretreatment serum Cyfra 21–1, tissue polypeptide antigen, and squamous cell carcinoma antigen levels in patients with cervical cancer , 1995, Cancer.

[59]  J. Erler,et al.  The potential for targeting extracellular LOX proteins in human malignancy , 2013, OncoTargets and therapy.