m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.

[1]  Qiang Xu,et al.  New opportunities and challenges of natural products research: When target identification meets single-cell multiomics , 2022, Acta pharmaceutica Sinica. B.

[2]  Y. Li,et al.  Naringenin is a Potential Immunomodulator for Inhibiting Liver Fibrosis by Inhibiting the cGAS-STING Pathway , 2022, Journal of clinical and translational hepatology.

[3]  P. Sassone-Corsi,et al.  Nutrition, metabolism, and epigenetics: pathways of circadian reprogramming , 2022, EMBO reports.

[4]  Feng Zhang,et al.  m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells. , 2022, Free radical biology & medicine.

[5]  Feng Zhang,et al.  Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis , 2022, Acta pharmaceutica Sinica. B.

[6]  Xinghuo Wu,et al.  Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis , 2022, Experimental & Molecular Medicine.

[7]  V. Anggono,et al.  The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. , 2021, Trends in genetics : TIG.

[8]  K. Ghoshal,et al.  METTL3 Regulates Liver Homeostasis, Hepatocyte Ploidy, and Circadian Rhythm-Controlled Gene Expression in Mice. , 2021, The American journal of pathology.

[9]  Feng Zhang,et al.  N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells , 2021, Redox biology.

[10]  A. Siddiqui,et al.  The role of N6-methyladenosine modification in the life cycle and disease pathogenesis of hepatitis B and C viruses , 2021, Experimental & Molecular Medicine.

[11]  H. Eltzschig,et al.  Circadian rhythm as a therapeutic target , 2021, Nature Reviews Drug Discovery.

[12]  Kewu Zeng,et al.  Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer , 2021, Acta pharmaceutica Sinica. B.

[13]  Chuan He,et al.  m6A RNA methylation: from mechanisms to therapeutic potential , 2021, The EMBO journal.

[14]  S. Friedman,et al.  The Power of Plasticity-Metabolic Regulation of Hepatic Stellate Cells. , 2020, Cell metabolism.

[15]  J. Qin,et al.  TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology. , 2020, Molecular cell.

[16]  Feng Zhang,et al.  Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1 , 2020, British journal of pharmacology.

[17]  B. Tang,et al.  PINK1 phosphorylates Drp1S616 to regulate mitophagy‐independent mitochondrial dynamics , 2020, EMBO reports.

[18]  Tian-Le Xu,et al.  DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation , 2020, Science Advances.

[19]  L. Scorrano,et al.  The cell biology of mitochondrial membrane dynamics , 2020, Nature Reviews Molecular Cell Biology.

[20]  A. Franchitto,et al.  Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies , 2020, Journal of pineal research.

[21]  M. Duchen,et al.  Mitochondria: An Integrative Hub Coordinating Circadian Rhythms, Metabolism, the Microbiome, and Immunity , 2020, Frontiers in Cell and Developmental Biology.

[22]  S. Jaffrey,et al.  Reading, writing and erasing mRNA methylation , 2019, Nature Reviews Molecular Cell Biology.

[23]  Ji-Young Lee,et al.  Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. , 2019, The Journal of nutritional biochemistry.

[24]  W. Syn,et al.  Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities , 2019, Drugs.

[25]  Jian Peng,et al.  Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation , 2019, Nucleic acids research.

[26]  P. Kamath,et al.  Burden of liver diseases in the world. , 2019, Journal of hepatology.

[27]  J. Takahashi,et al.  Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism. , 2018, Journal of molecular endocrinology.

[28]  Baojian Wu,et al.  REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis , 2018, Nature Communications.

[29]  F. Anania,et al.  Adiponectin inhibits hepatic stellate cell activation by targeting the PTEN/AKT pathway. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[30]  S. Cassel,et al.  Mitochondria in innate immune signaling. , 2018, Translational research : the journal of laboratory and clinical medicine.

[31]  D. Ezhilarasan Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective. , 2018, Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology.

[32]  Steven A. Brown,et al.  Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. , 2018, Cell metabolism.

[33]  S. Wen,et al.  REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1 , 2018, Drug Metabolism and Disposition.

[34]  Feng Zhang,et al.  Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α , 2018, Theranostics.

[35]  S. Campello,et al.  The mitochondrial dynamics in cancer and immune-surveillance. , 2017, Seminars in cancer biology.

[36]  Joel N Meyer,et al.  Mitochondrial fusion, fission, and mitochondrial toxicity. , 2017, Toxicology.

[37]  A. Ouchida,et al.  The role of mitochondria in metabolism and cell death. , 2017, Biochemical and biophysical research communications.

[38]  T. Jacks,et al.  Circadian Rhythm Disruption Promotes Lung Tumorigenesis. , 2016, Cell metabolism.

[39]  J. Nunnari,et al.  ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells , 2016, Science.

[40]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[41]  Li Wu,et al.  Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway. , 2016, International immunopharmacology.

[42]  I. Laher,et al.  Exercise Pills: At the Starting Line. , 2015, Trends in pharmacological sciences.

[43]  R. Schwabe,et al.  High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers , 2015, Nature Protocols.

[44]  M. Lazar,et al.  Nuclear receptor Rev-erbα: up, down, and all around , 2014, Trends in Endocrinology & Metabolism.

[45]  Eran Segal,et al.  Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis , 2014, Cell.

[46]  T. Kizaki,et al.  A Circadian Clock Gene, Rev-erbα, Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression , 2014, The Journal of Immunology.

[47]  Logan J Everett,et al.  Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. , 2012, Genes & development.

[48]  M. Mann,et al.  Universal sample preparation method for proteome analysis , 2009, Nature Methods.

[49]  G. Perkins,et al.  Mitochondrial fragmentation in neurodegeneration , 2008, Nature Reviews Neuroscience.