Life‐threatening retroperitoneal hemorrhage due to late vitamin K deficiency

The incidence of retroperitoneal and intraperitoneal hemorrhage is increased in preterm infants and in prolonged or complicated deliveries, especially with associated perinatal asphyxia or stress. The spectrum of presentation is considerable, ranging from asymptomatic to severe life-threatening intra-abdominal hemorrhage. Similarly, clinical examination may vary considerably and may be normal or demonstrate an abdominal mass with a significant hemorrhage. However, retroperitoneal hemorrhage associated with vitamin K deficiency is extremely rare and we have not come across such a case in our search of the medical literature. We report the first case of an infant diagnosed as having gross retroperitoneal and minimal intraperitoneal hemorrhage due to late vitamin K deficiency.

[1]  Hirokazu Sakai,et al.  Vitamin K deficiency bleeding with intracranial hemorrhage: focus on secondary form , 2007, Emergency Radiology.

[2]  H. Tan,et al.  Late vitamin K deficiency bleeding: 16 cases reviewed , 2007, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[3]  V. Ratageri,et al.  Vitreous hemorrhage secondary to vitamin K deficiency bleeding , 2007, Indian journal of pediatrics.

[4]  C. Polat,et al.  Coumadin-Induced Renal and Retroperitoneal Hemorrhage , 2006, Renal failure.

[5]  K. Kavaklı,et al.  Iliopsoas haemorrhage in patients with haemophilia: results from one centre , 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

[6]  K. Topgül,et al.  Surgical Management of Enoxaparin- and/or Warfarin-induced Massive Retroperitoneal Bleeding: Report of a Case and Review of the Literature , 2005, Southern medical journal.

[7]  H. Yavuz,et al.  INTRACRANIAL HEMORRHAGE DUE TO VITAMIN K DEFICIENCY AFTER THE NEWBORN PERIOD , 2004, Pediatric hematology and oncology.

[8]  K. Locham,et al.  Late hemorrhagic disease of newborn. , 2003, Indian pediatrics.

[9]  M. Totan.  Adrenal hemorrhage due to vitamin-k deficiency , 2002, Indian journal of pediatrics.

[10]  E. Grillo,et al.  [Intra-cranial hemorrhage in infants due to vitamin K deficiency - report of 2 cases] , 2000, Jornal de pediatria.

[11]  R. von Kries,et al.  Vitamin K Deficiency Bleeding (VKDB) in Infancy , 1999, Thrombosis and Haemostasis.

[12]  R. von Kries,et al.  Vitamin K deficiency bleeding (VKDB) in infancy. ISTH Pediatric/Perinatal Subcommittee. International Society on Thrombosis and Haemostasis. , 1999, Thrombosis and haemostasis.

[13]  Meral Özmen,et al.  Vitamin K deficiency--late onset intracranial haemorrhage. , 1998, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[14]  L. Israels.  Controversies concerning vitamin K and the newborn. , 2018, Pediatrics.

[15]  M. Chou,et al.  Intracranial hemorrhage and vitamin K deficiency in early infancy. , 1984, The Journal of pediatrics.