Non-enzymatic hydrogen peroxide sensor based on a gold electrode modified with granular cuprous oxide nanowires

AbstractGranular nanowires with a diameter of about 60 nm were fabricated from cuprous oxide (Cu2O) by an electrochemical method using anodic aluminium oxide as the template. A non-enzymatic sensor for hydrogen peroxide (H2O2) was then developed on the basis of a gold electrode modified with Cu2O nanowires and Nafion. The resulting sensor enables the determination of H2O2 with a sensitivity of 745 μA mM−1 cm−2, over a wide linear range (0.25 μM to 5.0 mM), and with a low detection limit (0.12 μM). The results demonstrate that the use of such granular nanowires provides a promising tool for the design of non-enzymatic chemical sensors. FigureA non-enzymatic sensor for hydrogen peroxide (H2O2) was developed on the basis of a gold electrode modified with Cu2O nanowires and Nafion. The resulting sensor enables the determination of H2O2 with a sensitivity of 745 μA mM−1 cm−2, over a wide linear range (0.25 μM to 5.0 mM), and with a low detection limit (0.12 μM). The results demonstrate that the use of such granular nanowires provides a promising tool for the design of non-enzymatic chemical sensors

[1]  Li Zhang,et al.  Facile synthesis of flower like copper oxide and their application to hydrogen peroxide and nitrite sensing , 2011, Chemistry Central journal.

[2]  Y. Qian,et al.  Well-aligned Cu2O nanowire arrays prepared by an ethylene glycol-reduced process , 2009 .

[3]  Song Li,et al.  Enzyme-free amperometric sensing of hydrogen peroxide and glucose at a hierarchical Cu2O modified electrode. , 2011, Talanta.

[4]  S. Mcginnis,et al.  Novel template-based semiconductor nanostructures and their applications , 2000 .

[5]  Kaiming Liao,et al.  Porous cuprous oxide microcubes for non-enzymatic amperometric hydrogen peroxide and glucose sensing , 2009 .

[6]  Yu Lei,et al.  Ultrasensitive and selective non-enzymatic glucose detection using copper nanowires. , 2012, Biosensors & bioelectronics.

[7]  Jiecai Han,et al.  Non-enzymatic hydrogen peroxide detection using gold nanoclusters-modified phosphorus incorporated tetrahedral amorphous carbon electrodes , 2010 .

[8]  M. Şenel,et al.  Amperometric hydrogen peroxide biosensor based on covalent immobilization of horseradish peroxidase on ferrocene containing polymeric mediator , 2010 .

[9]  J. Luong,et al.  Direct electrochemistry of horseradish peroxidase immobilized on a monolayer modified nanowire array electrode. , 2010, Biosensors & bioelectronics.

[10]  Dasgupta,et al.  Measurement of atmospheric hydrogen peroxide and hydroxymethyl hydroperoxide with a diffusion scrubber and light emitting diode-liquid core waveguide-based fluorometry , 2000, Analytical chemistry.

[11]  B. C. Madsen,et al.  Flow injection and photometric determination of hydrogen peroxide in rainwater with N-ethyl-N-(sulfopropyl)aniline sodium salt , 1984 .

[12]  Y. Chai,et al.  An amperometric hydrogen peroxide biosensor based on the immobilization of HRP on multi-walled carbon nanotubes/electro-copolymerized nano-Pt-poly(neutral red) composite membrane , 2010 .

[13]  M. Schäferling,et al.  Luminescent probes for detection and imaging of hydrogen peroxide , 2011 .

[14]  Bipin Nair,et al.  Single step modification of copper electrode for the highly sensitive and selective non-enzymatic determination of glucose , 2010 .

[15]  Yongsug Tak,et al.  Cu(2)O nanowires in an alumina template: electrochemical conditions for the synthesis and photoluminescence characteristics. , 2006, Chemphyschem : a European journal of chemical physics and physical chemistry.

[16]  Jenny Emnéus,et al.  Peroxidase-modified electrodes: Fundamentals and application , 1996 .

[17]  Fast and selective Cu2O nanorod growth into anodic alumina templates via electrodeposition , 2012 .

[18]  N. Zhang,et al.  A novel non-enzyme hydrogen peroxide sensor based on an electrode modified with carbon nanotube-wired CuO nanoflowers , 2011, Microchimica Acta.

[19]  Xue-wei Wang,et al.  Template-based synthesis and magnetic properties of Ni nanotube arrays with different diameters , 2011 .

[20]  B. Halliwell,et al.  Hydrogen peroxide in the human body , 2000, FEBS letters.

[21]  Xiangyu Lv,et al.  An improved sensitivity nonenzymatic glucose biosensor based on a CuxO modified electrode. , 2010, Biosensors & bioelectronics.

[22]  G. Shen,et al.  Amperometric H2O2 biosensor based on poly-thionine nanowire/HRP/nano-Au-modified glassy carbon electrode , 2008 .

[23]  H. Razmi,et al.  Trace Level Determination of Hydrogen Peroxide at a Carbon Ceramic Electrode Modified with Copper Oxide Nanostructures , 2011 .

[24]  Qing Guo,et al.  Application of tubular tetrapod magnesium oxide in a biosensor for hydrogen peroxide , 2012, Microchimica Acta.

[25]  Yibin Ying,et al.  Copper oxide nanoparticles and ionic liquid modified carbon electrode for the non-enzymatic electrochemical sensing of hydrogen peroxide , 2010 .

[26]  E. C. Hurdis,et al.  Accuracy of Determination of Hydrogen Peroxide by Cerate Oxidimetry , 1954 .

[27]  Ning Wang,et al.  A novel non-enzymatic glucose sensor modified with Fe2O3 nanowire arrays. , 2011, The Analyst.