Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
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B. Hyman | D. Standaert | T. Outeiro | A. Kazantsev | Stephen M. Altmann | Allison M Amore | T. Grammatopoulos | A. Amore
[1] B. Hyman,et al. Small Heat Shock Proteins Protect Against α-Synuclein-Induced Toxicity and Aggregation , 2006 .
[2] M. Beal,et al. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.
[3] J. Parvin,et al. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. , 2006, Human molecular genetics.
[4] W. Springer,et al. Mechanisms and models of α-synuclein-related neurodegeneration , 2006 .
[5] R. Abagyan,et al. Discovery of bioactive small-molecule inhibitor of poly adp-ribose polymerase: implications for energy-deficient cells. , 2006, Chemistry & biology.
[6] V. Schreiber,et al. Poly(ADP-ribose): novel functions for an old molecule , 2006, Nature Reviews Molecular Cell Biology.
[7] K. Maiese,et al. Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide. , 2006, Current medicinal chemistry.
[8] C. Szabó. Poly(ADP-ribose) polymerase activation by reactive nitrogen species--relevance for the pathogenesis of inflammation. , 2006, Nitric oxide : biology and chemistry.
[9] V. Dawson. Inhibition of poly(adenosine diphosphate-ribose) polymerase (PARP) in experimental models of neurologic diseases: cell death prevention. , 2005, Retina.
[10] T. Dawson,et al. Mediation of cell death by poly(ADP-ribose) polymerase-1. , 2005, Pharmacological research.
[11] L. Virág. Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies. , 2005, Current vascular pharmacology.
[12] Csaba Szabó,et al. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors , 2005, Nature Reviews Drug Discovery.
[13] E. Petermann,et al. Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes. , 2005, Cellular and molecular life sciences : CMLS.
[14] T. Dawson,et al. Poly(ADP-ribosyl)ation regulation of life and death in the nervous system. , 2005, Cellular and molecular life sciences : CMLS.
[15] C. Szabó,et al. Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation. , 2005, Cellular and molecular life sciences : CMLS.
[16] Andrew J Duncan,et al. Nitric oxide and neurological disorders. , 2005, Molecular aspects of medicine.
[17] B. Hyman,et al. Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro , 2004 .
[18] T. Dawson,et al. Deadly Conversations: Nuclear-Mitochondrial Cross-Talk , 2004, Journal of bioenergetics and biomembranes.
[19] G. de Murcia,et al. The PARP superfamily , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.
[20] M. Vila,et al. Genetic clues to the pathogenesis of Parkinson's disease , 2004, Nature Medicine.
[21] Jochen Klucken,et al. Hsp70 Reduces α-Synuclein Aggregation and Toxicity* , 2004, Journal of Biological Chemistry.
[22] A. Iwashita,et al. Neuroprotective Effects of a Novel Poly(ADP-Ribose) Polymerase-1 Inhibitor, 2-{3-[4-(4-Chlorophenyl)-1-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro Model of Cell Death and in Mouse 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of Parkinson's Disease , 2004, Journal of Pharmacology and Experimental Therapeutics.
[23] S. Lindquist,et al. Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology , 2003, Science.
[24] K. Heidenreich,et al. The pesticide rotenone induces caspase‐3‐mediated apoptosis in ventral mesencephalic dopaminergic neurons , 2003, Journal of neurochemistry.
[25] T. Dawson,et al. Molecular Pathways of Neurodegeneration in Parkinson's Disease , 2003, Science.
[26] Janel O. Johnson,et al. α-Synuclein Locus Triplication Causes Parkinson's Disease , 2003, Science.
[27] W. Dauer,et al. Parkinson's Disease Mechanisms and Models , 2003, Neuron.
[28] M. Vila,et al. The 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Mouse Model , 2003 .
[29] T. Dawson,et al. Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease , 2003, Annals of the New York Academy of Sciences.
[30] Nutan Sharma,et al. TorsinA and heat shock proteins act as molecular chaperones: suppression of α‐synuclein aggregation , 2002, Journal of neurochemistry.
[31] Robert Burke,et al. Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[32] J. Lumpkin,et al. A novel in vivo post‐translational modification of p53 by PARP‐1 in MPTP‐induced parkinsonism , 2002, Journal of neurochemistry.
[33] Ted M. Dawson,et al. Animal Models of PD Pieces of the Same Puzzle? , 2002, Neuron.
[34] J. Yun,et al. Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells. , 2002, Cancer letters.
[35] B. Hyman,et al. α-Synuclein–enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons , 2001, Neuroscience.
[36] C. Cosi,et al. Implication of Poly(ADP‐Ribose) Polymerase (PARP) in Neurodegeneration and Brain Energy Metabolism: Decreases in Mouse Brain NAD+ and ATP Caused by MPTP Are Prevented by the PARP Inhibitor Benzamide , 1999, Annals of the New York Academy of Sciences.
[37] D. Guastella,et al. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] E. Masliah,et al. Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment. , 1998, Laboratory investigation; a journal of technical methods and pathology.
[39] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[40] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[41] E. Masliah,et al. Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer’s disease, Lewy body disease and progressive supranuclear palsy , 1996, Acta Neuropathologica.