论文信息 - Tooth pulp stimulation: a method of determining the analgesic efficacy of meptazinol in man.

Tooth pulp stimulation: a method of determining the analgesic efficacy of meptazinol in man.

A dose-ranging study of meptazinol was carried out using the pain threshold to electrical tooth pulp stimulation in healthy volunteers as the pain model. A well defined dose-response curve was found for oral meptazinol (50 mg, 100 mg, 150 mg and 200 mg) and placebo. The methodology and results are discussed in terms of subsequent clinical experience with meptazinol.

R. K. Price | J. Gabka

[1] D. Littlejohns,et al. The clinical assessment of analgesic drugs. , 1981, British journal of clinical pharmacology.

[2] A. Wade,et al. First Impressions of the Use of Meptazinol in General Practice , 1981, The Journal of international medical research.

[3] Ward Pj,et al. A double blind comparison of meptazinol versus pentazocine in chronic rheumatoid and osteoarthritis. , 1980 .

[4] P. Ward,et al. A Double Blind Comparison of Meptazinol Versus Pentazocine in Chronic Rheumatoid and Osteoarthritis , 1980, The British journal of clinical practice.

[5] P. Robson,et al. Double-blind crossover trial of oral meptazinol, pentazocine and placebo in the treatment of pain in the elderly. , 1980, Postgraduate medical journal.

[6] L. Lasagna. Analgesic methodology: a brief history and commentary. , 1980, Journal of clinical pharmacology.

[7] R. Stephens,et al. A review of the biological properties and metabolic disposition of the new analgesic agent, meptazinol. , 1978, General pharmacology.