Inaccuracies Inherent in Dual‐Energy X‐Ray Absorptiometry In Vivo Bone Mineral Density Can Seriously Mislead Diagnostic/Prognostic Interpretations of Patient‐Specific Bone Fragility

SINCE ITS advent, noninvasive dual-energy X-ray absorptiometric (DXA) in vivo measurement of bone mineral density (BMD) has been accepted almost universally as the methodology of choice in the field of clinical bone fragility. More specifically, DXA generally is considered to be the prime, reliable assessor of the osteopenic/osteoporotic condition of bone fracture propensity, (6–9) of correlations of measured BMD with fracture failure load of bones, (10–17) and of the efficacy of remedial bone therapies. DXA also is held to be the standard against which newer, emerging alternative methods of bone quality assessment are evaluated. (27,28)

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