Theoretical formulation of sustained-release dosage forms.

The present investigation deals with the result of a mathematical and an analog computor analysis of the kinetic relationships governing the rate of release of (drugs from sustained-release dosage forms. Two types of release have been considered, those described by zero-order and those that can be described by first-order kinetics. In addition, mathematical equations are derived that permit the calculation of doses and of release constants that will give a blood concentration versus time curve most closely approximating an “idealized” curve.

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