Antihypertensive and vasodilator effect of A-80b, a new pyridazino indole derivative.

[1]  A. Monge,et al.  1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)-5H-pyridazino[4,5-b]indole. A new antihypertensive agent , 1991 .

[2]  J. Marriott.  A comparison of the effects of the calcium entry blockers, verapamil, diltiazem and flunarizine against contractions of the rat isolated aorta and portal vein , 1988, British journal of pharmacology.

[3]  T. Bolton,et al.  Calcium Channels and Calcium‐Mediated Effects in Smooth Muscle Cells , 1988, Journal of cardiovascular pharmacology.

[4]  T. Bolton,et al.  Voltage-dependent calcium channels in smooth muscle cells. , 1988, Journal of cardiovascular pharmacology.

[5]  A. Monge,et al.  Selective thromboxane synthetase inhibitors and antihypertensive agents. New derivatives of 4-hydrazino-5H-pyridazino[4,5-b]indole, 4-hydrazinopyridazino[4,5-a]indole, and related compounds. , 1987, Journal of medicinal chemistry.

[6]  J. Clapham,et al.  α1-Adrenoceptor‐Mediated Contraction of Rabbit Mesenteric Artery: A Role for Intra‐ and Extracellular Calcium Pools , 1987, Journal of cardiovascular pharmacology.

[7]  H. Yamamoto,et al.  Vascular Smooth Muscle Calcium Channels , 1987, Journal of cardiovascular pharmacology.

[8]  A. Johns,et al.  Ca2+ regulation of vascular smooth muscle. , 1986, Federation proceedings.

[9]  H. Kita,et al.  Antihypertensive and cardiovascular effects of the new dihydropyridine derivative methyl (E)-3-phenyl-2-propen-1-yl-1,4-dihydro-2,6-dimethyl- 4-(3-nitrophenyl)pyridine-3,5-dicarboxylate. , 1986, Arzneimittel-Forschung.

[10]  J. Tamargo,et al.  Effects of pincainide on contractile responses and 45Ca movements in rat isolated vascular smooth muscle. , 1985, European journal of pharmacology.

[11]  S. Malik,et al.  Induction of Ca++ influx and intracellular Ca++ release in isolated rat aorta and mesenteric resistance vessels by norepinephrine activation of alpha-1 receptors. , 1984, The Journal of pharmacology and experimental therapeutics.

[12]  R. Furchgott,et al.  Endothelial cells as mediators of vasodilation of arteries. , 1984, Journal of cardiovascular pharmacology.

[13]  M. Font,et al.  Antihypertensive agents: pyridazino (4,5-b)indole derivatives. , 1982, Journal of pharmaceutical sciences.

[14]  R. Heaslip,et al.  Evidence for the existence of two distinct pools of intracellular calcium in the rat aorta accessible to mobilization by norepinephrine. , 1982, The Journal of pharmacology and experimental therapeutics.

[15]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[16]  T. Bolton.  Mechanisms of action of transmitters and other substances on smooth muscle. , 1979, Physiological reviews.

[17]  B. Uvelius,et al.  Relative contribution of superficially bound and extracellular calcium to activation of contraction in isolated rat portal vein. , 1975, Acta physiologica Scandinavica.