Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis
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K. Basso | L. Pasqualucci | M. Bansal | A. Holmes | Jiyuan Zhang | Ji-Eun Lee | K. Ge | Tongwei Mo | D. Dominguez-Sola | Shafinaz Hussein | R. Dalla-Favera | Hongyan Tang | Sofija Vlasevska
[1] K. Basso,et al. Germinal centres and B cell lymphomagenesis , 2015, Nature Reviews Immunology.
[2] Ash A. Alizadeh,et al. Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation , 2015, Proceedings of the National Academy of Sciences.
[3] Scott A. Armstrong,et al. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier , 2014, Nature.
[4] A. Melnick,et al. Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. , 2014, Trends in molecular medicine.
[5] Raul Rabadan,et al. Genetics of follicular lymphoma transformation. , 2014, Cell reports.
[6] M. Calaminici,et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma , 2013, Nature Genetics.
[7] Charles Y. Lin,et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. , 2013, Cancer cell.
[8] Weiqun Peng,et al. H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation , 2013, eLife.
[9] R. McLendon,et al. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation , 2013, Oncotarget.
[10] A. Shilatifard,et al. The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers , 2013, Molecular and Cellular Biology.
[11] J. Stender,et al. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. , 2013, Molecular cell.
[12] L. Pasqualucci. The genetic basis of diffuse large B-cell lymphoma , 2013, Current opinion in hematology.
[13] O. Elemento,et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. , 2013, Cancer cell.
[14] David A. Orlando,et al. Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes , 2013, Cell.
[15] David A. Orlando,et al. Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers , 2013, Cell.
[16] J. Wysocka,et al. Modification of enhancer chromatin: what, how, and why? , 2013, Molecular cell.
[17] I. Amit,et al. High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states , 2013, Nature Protocols.
[18] L. Lam,et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets , 2013, Nature Medicine.
[19] David Dunson,et al. Genetic heterogeneity of diffuse large B-cell lymphoma , 2013, Proceedings of the National Academy of Sciences.
[20] Min Gyu Lee,et al. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. , 2012, Genes & development.
[21] Alexander S. Garruss,et al. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. , 2012, Genes & development.
[22] Ash A. Alizadeh,et al. Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma. , 2012, Blood.
[23] Tim J. Wigle,et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. , 2012, Nature chemical biology.
[24] Yan Liu,et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations , 2012, Nature.
[25] R. McLendon,et al. Global identification of MLL2-targeted loci reveals MLL2’s role in diverse signaling pathways , 2012, Proceedings of the National Academy of Sciences.
[26] Charles Y. Lin,et al. Transcriptional Amplification in Tumor Cells with Elevated c-Myc , 2012, Cell.
[27] M. Nussenzweig,et al. The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry , 2012, Nature Immunology.
[28] E. Canaani,et al. TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication , 2012, Cell.
[29] A. Shilatifard. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. , 2012, Annual review of biochemistry.
[30] L. Staudt,et al. Pathogenesis of human B cell lymphomas. , 2012, Annual review of immunology.
[31] Steven L Salzberg,et al. Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.
[32] Eric S. Lander,et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing , 2012, Proceedings of the National Academy of Sciences.
[33] Steven J. M. Jones,et al. Frequent mutation of histone modifying genes in non-Hodgkin lymphoma , 2011, Nature.
[34] M. Ardehali,et al. Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription , 2011, The EMBO journal.
[35] Raul Rabadan,et al. Analysis of the Coding Genome of Diffuse Large B-Cell Lymphoma , 2011, Nature Genetics.
[36] Olivier Elemento,et al. An integrated ChIP-seq analysis platform with customizable workflows , 2011, BMC Bioinformatics.
[37] Ryan A. Flynn,et al. A unique chromatin signature uncovers early developmental enhancers in humans , 2011, Nature.
[38] Raul Rabadan,et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma , 2010, Nature.
[39] Govind Bhagat,et al. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. , 2010, Cancer cell.
[40] R. Young,et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state , 2010, Proceedings of the National Academy of Sciences.
[41] Emily H Turner,et al. Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome , 2010, Nature Genetics.
[42] M. Cooke,et al. Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate , 2010, Nature Reviews Immunology.
[43] Gonçalo R. Abecasis,et al. The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..
[44] R. Dalla‐Favera,et al. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma , 2009, Nature.
[45] Wei Keat Lim,et al. Master Regulators Used As Breast Cancer Metastasis Classifier , 2008, Pacific Symposium on Biocomputing.
[46] Jill P. Mesirov,et al. GSEA-P: a desktop application for Gene Set Enrichment Analysis , 2007, Bioinform..
[47] J. Kutok,et al. B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. , 2007, Immunity.
[48] T. Kouzarides. Chromatin Modifications and Their Function , 2007, Cell.
[49] Bing Li,et al. The Role of Chromatin during Transcription , 2007, Cell.
[50] Qiong Shen,et al. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination , 2006, Nature Immunology.
[51] K. Rajewsky,et al. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[52] J. Mesirov,et al. GenePattern 2.0 , 2006, Nature Genetics.
[53] Qiong Shen,et al. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. , 2005, Cancer cell.
[54] Qing Ge,et al. Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[55] A. W. Harris,et al. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. , 2004, Blood.
[56] Andrea Califano,et al. Transcriptional analysis of the B cell germinal center reaction , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[57] Wei Gu,et al. Acetylation inactivates the transcriptional repressor BCL6 , 2002, Nature Genetics.
[58] Nevan J. Krogan,et al. COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression* , 2002, The Journal of Biological Chemistry.
[59] Rein Aasland,et al. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4 , 2001, The EMBO journal.
[60] J. Davie,et al. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. , 2001, Genes & development.
[61] S. Shinton,et al. Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation1 , 2001, The Journal of Immunology.
[62] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[63] Nevan J. Krogan,et al. COMPASS: A complex of proteins associated with a trithorax-related SET domain protein , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[64] Gouri Nanjangud,et al. Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas , 2001, Nature.
[65] C. Rudd. Lnk Adaptor: Novel Negative Regulator of B Cell Lymphopoiesis , 2001, Science's STKE.
[66] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[67] Ash A. Alizadeh,et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.
[68] A. Yoshimura,et al. Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation , 1997, Oncogene.
[69] M. Neuberger,et al. Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice. , 1997, Nucleic acids research.
[70] K. Rajewsky,et al. B lymphocyte-specific, Cre-mediated mutagenesis in mice. , 1997, Nucleic acids research.
[71] G. Köhler,et al. Transitional B cells are the target of negative selection in the B cell compartment , 1995, The Journal of experimental medicine.
[72] G. Kelsoe,et al. In Situ Studies of the Primary Immune Response to ( 4-hydroxy-3-nitrophenyl ) acetyl . II . A Common Clonal Origin for Periarteriolar Lymphoid Sheath-associated Foci and Germinal Centers , 2003 .
[73] I. Maclennan,et al. Mechanism of antigen-driven selection in germinal centres , 1989, Nature.
[74] L. Pasqualucci,et al. AID is required for germinal center–derived lymphomagenesis , 2008, Nature Genetics.
[75] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[76] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[77] Thomas D. Schmittgen,et al. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method , 2022 .