Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

PKA and CaM kinase II both target the histone deacetylase HDAC4 such that the former antagonizes MEF2 activity and the latter promotes it.

[1]  B. Aronow,et al.  Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins , 2011, The Journal of cell biology.

[2]  D. Bers,et al.  Reactive Oxygen Species–Activated Ca/Calmodulin Kinase II&dgr; Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload , 2011, Circulation research.

[3]  Jennifer Liu,et al.  Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes , 2011, Development.

[4]  F. Lezoualc’h,et al.  Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway. , 2010, Cellular signalling.

[5]  Keshava Rajagopal,et al.  Teaching old receptors new tricks: biasing seven-transmembrane receptors , 2010, Nature Reviews Drug Discovery.

[6]  H. Rockman,et al.  β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation , 2010, The Journal of cell biology.

[7]  S. Keteyian,et al.  Clinical role of exercise training in the management of patients with chronic heart failure. , 2010, Journal of cardiopulmonary rehabilitation and prevention.

[8]  S. McGee,et al.  Histone modifications and skeletal muscle metabolic gene expression , 2010, Clinical and Experimental Pharmacology and Physiology.

[9]  J. Brown,et al.  Beta-adrenergic receptor signaling in the heart: role of CaMKII. , 2010, Journal of molecular and cellular cardiology.

[10]  Chad E. Grueter,et al.  The γ isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption , 2009, Proceedings of the National Academy of Sciences.

[11]  Mark E. Anderson,et al.  Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. , 2009, The Journal of clinical investigation.

[12]  Hugo A. Katus,et al.  The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload , 2009, Proceedings of the National Academy of Sciences.

[13]  S. Vatner,et al.  A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy , 2008, Cell.

[14]  Mark E. Anderson,et al.  A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation , 2008, Cell.

[15]  E. Olson,et al.  Histone Deacetylase 5 Acquires Calcium/Calmodulin-Dependent Kinase II Responsiveness by Oligomerization with Histone Deacetylase 4 , 2008, Molecular and Cellular Biology.

[16]  A. Mai,et al.  Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A Activation and Class II Histone Deacetylases Nuclear Shuttling , 2008, Circulation research.

[17]  Da-Zhi Wang,et al.  The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. , 2008, The Journal of clinical investigation.

[18]  E. Olson,et al.  CaMKIIδ Isoforms Differentially Affect Calcium Handling but Similarly Regulate HDAC/MEF2 Transcriptional Responses* , 2007, Journal of Biological Chemistry.

[19]  C. Brancolini,et al.  PP2A regulates HDAC4 nuclear import. , 2007, Molecular biology of the cell.

[20]  D. Fasino,et al.  Dephosphorylation and Caspase Processing Generate Distinct Nuclear Pools of Histone Deacetylase 4 , 2007, Molecular and Cellular Biology.

[21]  O. Osadchii Cardiac hypertrophy induced by sustained β-adrenoreceptor activation: pathophysiological aspects , 2007, Heart Failure Reviews.

[22]  Gillian H. Little,et al.  Nuclear Calcium/Calmodulin-dependent Protein Kinase IIδ Preferentially Transmits Signals to Histone Deacetylase 4 in Cardiac Cells* , 2007, Journal of Biological Chemistry.

[23]  T. McKinsey Derepression of pathological cardiac genes by members of the CaM kinase superfamily. , 2007, Cardiovascular research.

[24]  L. Leinwand,et al.  Shuttling of HDAC5 in H9C2 cells regulates YY1 function through CaMKIV/PKD and PP2A. , 2006, American journal of physiology. Cell physiology.

[25]  E. Olson,et al.  Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10 , 2006, Cell.

[26]  E. Olson,et al.  CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. , 2006, The Journal of clinical investigation.

[27]  S. Kageyama,et al.  Stage specific expression of histone deacetylase 4 (HDAC4) during oogenesis and early preimplantation development in mice. , 2006, The Journal of reproduction and development.

[28]  J. Molkentin,et al.  Temporally Controlled Onset of Dilated Cardiomyopathy Through Disruption of the SRF Gene in Adult Heart , 2005, Circulation.

[29]  J. Molkentin,et al.  The DnaJ-Related Factor Mrj Interacts with Nuclear Factor of Activated T Cells c3 and Mediates Transcriptional Repression through Class II Histone Deacetylase Recruitment , 2005, Molecular and Cellular Biology.

[30]  T. Yao,et al.  Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death , 2005, The Journal of Neuroscience.

[31]  Stefan Offermanns,et al.  Mammalian G proteins and their cell type specific functions. , 2005, Physiological reviews.

[32]  R. Schwartz,et al.  Conditional Mutagenesis of the Murine Serum Response Factor Gene Blocks Cardiogenesis and the Transcription of Downstream Gene Targets* , 2005, Journal of Biological Chemistry.

[33]  R. Herrmann,et al.  Experimental proof for a signal peptidase I like activity in Mycoplasma pneumoniae, but absence of a gene encoding a conserved bacterial type I SPase , 2005, The FEBS journal.

[34]  John M. Shelton,et al.  Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis , 2004, Cell.

[35]  M. Crow,et al.  Sustained &bgr;1-Adrenergic Stimulation Modulates Cardiac Contractility by Ca2+/Calmodulin Kinase Signaling Pathway , 2004 .

[36]  E. Olson,et al.  Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development , 2004, Molecular and Cellular Biology.

[37]  G. Kao,et al.  Caspase-mediated Specific Cleavage of Human Histone Deacetylase 4* , 2004, Journal of Biological Chemistry.

[38]  G. Del Sal,et al.  Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. , 2004, Molecular biology of the cell.

[39]  R. Schwartz,et al.  Calcium/Calmodulin-dependent Protein Kinase Activates Serum Response Factor Transcription Activity by Its Dissociation from Histone Deacetylase, HDAC4 , 2003, Journal of Biological Chemistry.

[40]  F. Dequiedt,et al.  Class II histone deacetylases: versatile regulators. , 2003, Trends in genetics : TIG.

[41]  B. Kobilka,et al.  Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II. , 2003, The Journal of clinical investigation.

[42]  G. Fishman,et al.  Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  Chun Li Zhang,et al.  Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy , 2002, Cell.

[44]  R. Idzerda,et al.  Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. , 2002, Molecular endocrinology.

[45]  D. Bers Cardiac excitation–contraction coupling , 2002, Nature.

[46]  E. Olson,et al.  Identification of a Signal-Responsive Nuclear Export Sequence in Class II Histone Deacetylases , 2001, Molecular and Cellular Biology.

[47]  E. Olson,et al.  Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation , 2000, Nature.

[48]  S. Schreiber,et al.  Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[49]  R. Passier,et al.  CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo. , 2000, The Journal of clinical investigation.

[50]  E. Miska,et al.  HDAC4 deacetylase associates with and represses the MEF2 transcription factor , 1999, The EMBO journal.

[51]  Fach,et al.  Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF) , 1999, The Lancet.

[52]  E. Olson,et al.  Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. , 1999, Development.

[53]  R. Lefkowitz,et al.  Myocardial β-adrenergic receptor signaling in vivo: insights from transgenic mice , 1996, Journal of Molecular Medicine.

[54]  G. Lyons,et al.  Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. , 1994, Development.

[55]  M. Caron,et al.  Turning off the signal: desensitization of β‐adrenergic receptor function , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[56]  M. Bristow,et al.  Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. , 1986, Circulation.

[57]  J. Cohn,et al.  Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. , 1984, The New England journal of medicine.

[58]  E. Olson,et al.  The many roles of histone deacetylases in development and physiology: implications for disease and therapy , 2009, Nature Reviews Genetics.

[59]  M. Crow,et al.  Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. , 2004, Circulation research.

[60]  E. Olson,et al.  Balancing contractility and energy production: the role of myocyte enhancer factor 2 (MEF2) in cardiac hypertrophy. , 2004, Recent progress in hormone research.

[61]  G. Fishman,et al.  Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[62]  R. Lefkowitz,et al.  Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. , 1996, Journal of molecular medicine.

[63]  G. Lyons,et al.  Mef 2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis , 1994 .

[64]  E. Olson,et al.  Control of cardiac growth by histone acetylation/deacetylation. , 2005, Circulation research.