Airways inflammation after exposure in a swine confinement building during cleaning procedure.

BACKGROUND Healthy volunteers exposed for 3 hr during weighing of pigs develop an airway inflammation characterized by a massive influx of neutrophilic granulocytes in the upper and lower airways and increased bronchial responsiveness to methacholine. The purpose of the present study was to investigate health effects from exposure during cleaning of the swine confinement building and to evaluate the effect of a respiratory protection device. METHODS Sixteen subjects were exposed for 3 hr during cleaning of a swine confinement room with a high-pressure cleaner. Seven out of sixteen subjects were equipped with a mask during exposure. RESULTS The bronchial responsiveness increased in all subjects following exposure, significantly more in the group exposed without a mask (P < 0.05). The cell concentration (mainly neutrophilic granulocytes) in nasal lavage fluid as well as the concentration of interleukin-8, increased significantly only in those subjects exposed without a respiratory protection device. In peripheral blood, an increase of neutrophilic granulocytes was observed in both groups, although it was significantly higher in the group without mask (P < 0.05). The inhalable dust level was 0.94 (0.74 - 1.55) mg/m(3) and respirable dust 0.56 (0.51-0.63) mg/m(3). CONCLUSION Exposure to dust aerosols during the cleaning of the interior of a swine confinement building induces increased bronchial responsiveness and an acute inflammatory reaction in the upper airways. The use of a mask attenuated but did not abolish the inflammatory response. This suggests that gases and/or ultrafine particles in this environment could be important factors in the development of increased bronchial responsiveness.

[1]  S. Lemay,et al.  Positive human health effects of wearing a respirator in a swine barn. , 2000, Chest.

[2]  D. Gavhed,et al.  Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects. , 1998, The European respiratory journal.

[3]  M. Laviolette,et al.  Effect of route of breathing on response to exposure in a swine confinement building. , 1998, American journal of respiratory and critical care medicine.

[4]  L. Palmberg,et al.  Induction of IL-8 production in human alveolar macrophages and human bronchial epithelial cells in vitro by swine dust , 1998, Thorax.

[5]  R. Sergysels,et al.  Dose-response relationship to inhaled endotoxin in normal subjects. , 1997, American journal of respiratory and critical care medicine.

[6]  L. Palmberg,et al.  Effect of exposure to swine dust on levels of IL-8 in airway lavage fluid. , 1997, Thorax.

[7]  L. Palmberg,et al.  Inhalation of swine dust induces cytokine release in the upper and lower airways. , 1997, The European respiratory journal.

[8]  H. Folgering,et al.  Bronchial hyperresponsiveness and exposure in pig farmers , 1997, International archives of occupational and environmental health.

[9]  R. Burnham,et al.  Effects of 10-ppm hydrogen sulfide inhalation on pulmonary function in healthy men and women. , 1996, Journal of occupational and environmental medicine.

[10]  B. Larsson,et al.  Time course of interleukin-6 and tumor necrosis factor-alpha increase in serum following inhalation of swine dust. , 1996, American journal of respiratory and critical care medicine.

[11]  John L. Hankinson,et al.  Standardization of Spirometry, 1994 Update. American Thoracic Society. , 1995, American journal of respiratory and critical care medicine.

[12]  L. Burmeister,et al.  Respiratory dysfunction in swine production facility workers: dose-response relationships of environmental exposures and pulmonary function. , 1995, American journal of industrial medicine.

[13]  L. Hansson,et al.  Swine dust causes intense airways inflammation in healthy subjects. , 1994, American journal of respiratory and critical care medicine.

[14]  J. Dosman,et al.  Respiratory health of swine producers. Focus on young workers. , 1993, Chest.

[15]  R. Rylander,et al.  Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. , 1992, The European respiratory journal.

[16]  A. Eklund,et al.  Alterations in bronchoalveolar lavage fluid but not in lung function and bronchial responsiveness in swine confinement workers. , 1992, Chest.

[17]  P. Malmberg,et al.  Increased lung deposition and biological effect of methacholine by use of a drying device for bronchial provocation tests. , 1991, The European respiratory journal.

[18]  T. Haahtela,et al.  Exposure to hydrogen sulphide and respiratory function. , 1990, British journal of industrial medicine.

[19]  R Rylander,et al.  Environmental and health studies of farm workers in Swedish swine confinement buildings. , 1989, British journal of industrial medicine.

[20]  R. Dahl,et al.  Respiratory symptoms in Danish farmers: an epidemiological study of risk factors. , 1988, Thorax.

[21]  U. Pipkorn,et al.  A brush method to harvest cells from the nasal mucosa for microscopic and biochemical analysis. , 1988, Journal of immunological methods.

[22]  R. Naclerio,et al.  The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment. , 1988, The American review of respiratory disease.

[23]  H. Hedenström,et al.  Reference values for lung function tests in men: regression equations with smoking variables. , 1986, Upsala journal of medical sciences.