Administration of vancomycin during cardiopulmonary bypass

Vancomycin was given during cardiopulmonary bypass to 12 anaesthetised patients undergoing open heart surgery. Injection of vancomycin 1 g within 60 s via the venous inlet of the oxygenator resulted in a moderate and transient decrease of mean arterial pressure. This minimal reaction may be attributed to dilution of vancomycin by the extracorporeal circuit volume, to the bypassing of the lungs which are a major site of storage of vasoactive substances, or to the maintenance of adequate perfusion flow during cardiopulmonary bypass. The results suggest that the haemodynamic adverse reactions to vancomycin, given as antibiotic prophylaxis, may be decreased by its administration after initiation of cardiopulmonary bypass.

[1]  G. Fita,et al.  Adverse reactions to vancomycin prophylaxis in cardiac surgery. , 1991, Journal of cardiothoracic and vascular anesthesia.

[2]  S. Kumar,et al.  Cardiovascular collapse and refractory bronchospasm following administration of vancomycin, esmolol, and heparin. , 1989, Journal of cardiothoracic anesthesia.

[3]  A. Baraka,et al.  Action of adrenergic agonists on resistance v capacitance vessels during cardiopulmonary bypass. , 1989, Journal of cardiothoracic anesthesia.

[4]  M. Belani,et al.  PROGNOSTIC VALUE OF PREOPERATIVE NONINVASIVE DOPPLER MEASUREMENTS OF CARDIAC INDEX, A PILOT STUDY , 1987 .

[5]  C. Hirshman,et al.  Histamine release by vancomycin: a mechanism for hypotension in man. , 1987, Anesthesiology.

[6]  A. Smith,et al.  The "red man's syndrome" and slow infusion of vancomycin. , 1986, Annals of internal medicine.

[7]  P. Casthely,et al.  Hemodynamic Changes after the Administration of Protamine , 1986, Anesthesia and analgesia.

[8]  S. Rosansky,et al.  Red neck syndrome with slow infusion of vancomycin. , 1986, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[9]  H. Leaver,et al.  Anaphylactoid reactions to vancomycin during anaesthesia: two clinical reports , 1985, Canadian Anaesthetists' Society journal.

[10]  J. Mayhew,et al.  Cardiac arrest following administration of vancomycin , 1985, Canadian Anaesthetists' Society journal.

[11]  H. Laks,et al.  Profound hypotension from rapid vancomycin administration during cardiac operation. , 1984, The Journal of thoracic and cardiovascular surgery.

[12]  C. Higgins,et al.  Cardiovascular effects of protamine sulfate. , 1981, Investigative radiology.

[13]  H. Tausk,et al.  Anaphylactoid reaction to vancomycin during anesthesia: a case report. , 1977, Anesthesia and analgesia.

[14]  W. Austen,et al.  Cardiovascular effects of protamine sulfate. , 1969, The Annals of thoracic surgery.

[15]  O. Inchley.  Histamine shock , 1926, The Journal of physiology.