Social anxiety and age are associated with neural response to social evaluation during adolescence

Highlights • Brain response to social feedback varies by age and social anxiety severity in youth.• Younger, anxious youth show greater activation to unpredictable negative feedback.• Different associations emerge among older, anxious adolescents.

[1]  K. Pelphrey,et al.  An integrative neural model of social perception, action observation, and theory of mind , 2015, Neuroscience & Biobehavioral Reviews.

[2]  Jonathan D. Cohen,et al.  The Expected Value of Control: An Integrative Theory of Anterior Cingulate Cortex Function , 2013, Neuron.

[3]  A. Hayes Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach , 2013 .

[4]  L. Somerville,et al.  Adolescent-specific patterns of behavior and neural activity during social reinforcement learning , 2014, Cognitive, affective & behavioral neuroscience.

[5]  Beatriz Luna,et al.  Developmental changes in brain function underlying the influence of reward processing on inhibitory control , 2011, Developmental Cognitive Neuroscience.

[6]  Sandra M. Neer,et al.  The Screen for Child Anxiety Related Emotional Disorders (SCARED): scale construction and psychometric characteristics. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[7]  J. Rapoport,et al.  Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: Ages 4–18 years , 1995, The Journal of comparative neurology.

[8]  D. Pine,et al.  Neural circuitry underlying affective response to peer feedback in adolescence. , 2012, Social cognitive and affective neuroscience.

[9]  E. Crone,et al.  Neural correlates of prosocial peer influence on public goods game donations during adolescence. , 2016, Social cognitive and affective neuroscience.

[10]  Carrie L. Masten,et al.  Neural correlates of social exclusion during adolescence: understanding the distress of peer rejection. , 2009, Social cognitive and affective neuroscience.

[11]  E. Leibenluft,et al.  Early-Childhood Social Reticence Predicts Brain Function in Preadolescent Youths During Distinct Forms of Peer Evaluation , 2016, Psychological science.

[12]  Ronald E. Dahl,et al.  Pubertal development and behavior: Hormonal activation of social and motivational tendencies , 2010, Brain and Cognition.

[13]  Bregtje Gunther Moor,et al.  Please Scroll down for Article Social Neuroscience Do You like Me? Neural Correlates of Social Evaluation and Developmental Trajectories Do You like Me? Neural Correlates of Social Evaluation and Developmental Trajectories Neural Correlates of Peer Evaluation , 2022 .

[14]  Elizabeth Jefferies,et al.  Heterogeneity of the Left Temporal Lobe in Semantic Representation and Control: Priming Multiple versus Single Meanings of Ambiguous Words , 2010, Cerebral cortex.

[15]  Paul A. Taylor,et al.  FMRI Clustering in AFNI: False-Positive Rates Redux , 2017, Brain Connect..

[16]  Ashley R. Smith,et al.  Age differences in the impact of peers on adolescents’ and adults’ neural response to reward , 2014, Developmental Cognitive Neuroscience.

[17]  Daniel S Pine,et al.  Probing the neural correlates of anticipated peer evaluation in adolescence. , 2009, Child development.

[18]  Christopher S. Monk,et al.  Dynamic changes in amygdala activation and functional connectivity in children and adolescents with anxiety disorders , 2014, Development and Psychopathology.

[19]  Christopher S. Monk,et al.  ALTERED ACTIVATION OF THE ROSTRAL ANTERIOR CINGULATE CORTEX IN THE CONTEXT OF EMOTIONAL FACE DISTRACTORS IN CHILDREN AND ADOLESCENTS WITH ANXIETY DISORDERS , 2014, Depression and anxiety.

[20]  Georgia Koppe,et al.  Temporal unpredictability of a stimulus sequence affects brain activation differently depending on cognitive task demands , 2014, NeuroImage.

[21]  E. Leibenluft,et al.  I Like Them…Will They Like Me? Evidence for the Role of the Ventrolateral Prefrontal Cortex During Mismatched Social Appraisals in Anxious Youth. , 2018, Journal of child and adolescent psychopharmacology.

[22]  Sarah-Jayne Blakemore,et al.  Is there heightened sensitivity to social reward in adolescence? , 2016, Current Opinion in Neurobiology.

[23]  Carol A. Seger,et al.  Dynamics of frontal, striatal, and hippocampal systems during rule learning. , 2005, Cerebral cortex.

[24]  L. Steinberg,et al.  Peers increase adolescent risk taking by enhancing activity in the brain's reward circuitry. , 2011, Developmental science.

[25]  Andrew F. Hayes,et al.  Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations , 2009, Behavior research methods.

[26]  L. Somerville The Teenage Brain , 2013 .

[27]  Gregory Hickok,et al.  The functional neuroanatomy of language. , 2009, Physics of life reviews.

[28]  A. Craig,et al.  How do you feel — now? The anterior insula and human awareness , 2009, Nature Reviews Neuroscience.

[29]  L. Somerville Special issue on the teenage brain: Sensitivity to social evaluation. , 2013, Current directions in psychological science.

[30]  Samuel M. McClure,et al.  Predictability Modulates Human Brain Response to Reward , 2001, The Journal of Neuroscience.

[31]  T. Insel,et al.  Wesleyan University From the SelectedWorks of Charles A . Sanislow , Ph . D . 2010 Research Domain Criteria ( RDoC ) : Toward a New Classification Framework for Research on Mental Disorders , 2018 .

[32]  Carrie L. Masten,et al.  Entering Adolescence: Resistance to Peer Influence, Risky Behavior, and Neural Changes in Emotion Reactivity , 2011, Neuron.

[33]  E. Nelson,et al.  Social re-orientation and brain development: An expanded and updated view , 2015, Developmental Cognitive Neuroscience.

[34]  Ruth Seurinck,et al.  Power and sample size calculations for fMRI studies based on the prevalence of active peaks , 2016, bioRxiv.

[35]  Gail M. Rosenbaum,et al.  Peers influence adolescent reward processing, but not response inhibition , 2018, Cognitive, affective & behavioral neuroscience.

[36]  Adrienne L. Romer,et al.  Forgetting the best when predicting the worst: Preliminary observations on neural circuit function in adolescent social anxiety , 2015, Developmental Cognitive Neuroscience.

[37]  D. Wagner,et al.  Mass univariate testing biases the detection of interaction effects in whole-brain analysis of variance , 2017, bioRxiv.

[38]  H. van Steenbergen,et al.  Altered Neurobiological Processing of Unintentional Social Norm Violations: A Multiplex, Multigenerational Functional Magnetic Resonance Imaging Study on Social Anxiety Endophenotypes. , 2020, Biological psychiatry. Cognitive neuroscience and neuroimaging.

[39]  Leslie G. Ungerleider,et al.  Facial Expressions Evoke Differential Neural Coupling in Macaques , 2016, Cerebral cortex.

[40]  Jonathan D. Power,et al.  Prediction of Individual Brain Maturity Using fMRI , 2010, Science.

[41]  Serge A. R. B. Rombouts,et al.  Social exclusion and punishment of excluders: Neural correlates and developmental trajectories , 2012, NeuroImage.

[42]  A. Craig How do you feel? Interoception: the sense of the physiological condition of the body , 2002, Nature Reviews Neuroscience.

[43]  D. Pine,et al.  The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. , 1998, Archives of general psychiatry.

[44]  Sarah-Jayne Blakemore,et al.  Is adolescence a sensitive period for sociocultural processing? , 2014, Annual review of psychology.

[45]  Adriana Galván,et al.  Teens Impulsively React rather than Retreat from Threat , 2014, Developmental Neuroscience.

[46]  E. Leibenluft,et al.  Neuroimaging studies of pediatric social anxiety: paradigms, pitfalls and a new direction for investigating the neural mechanisms , 2013, Biology of Mood & Anxiety Disorders.

[47]  N. Fox,et al.  Lasting associations between early-childhood temperament and late-adolescent reward-circuitry response to peer feedback , 2014, Development and Psychopathology.

[48]  Serge A. R. B. Rombouts,et al.  Dissociable brain networks involved in development of fairness considerations: Understanding intentionality behind unfairness , 2011, NeuroImage.

[49]  Erin B. McClure-Tone,et al.  Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. , 2008, Archives of general psychiatry.

[50]  E. Crone,et al.  Understanding adolescence as a period of social–affective engagement and goal flexibility , 2012, Nature Reviews Neuroscience.

[51]  E. Nelson Learning through the ages: How the brain adapts to the social world across development , 2017 .

[52]  Peter M. Bentler,et al.  Data Modeling: Structural Equation Modeling , 2006 .

[53]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[54]  P. C. Murphy,et al.  Cerebral Cortex , 2017, Cerebral Cortex.

[55]  R. Friend,et al.  Measurement of social-evaluative anxiety. , 1969, Journal of consulting and clinical psychology.

[56]  T. Yarkoni Big Correlations in Little Studies: Inflated fMRI Correlations Reflect Low Statistical Power—Commentary on Vul et al. (2009) , 2009, Perspectives on psychological science : a journal of the Association for Psychological Science.

[57]  T. Ollendick,et al.  Does comorbidity predict poorer treatment outcome in pediatric anxiety disorders? An updated 10-year review. , 2017, Clinical psychology review.

[58]  N. Ryan,et al.  Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[59]  Monique Ernst,et al.  Attention biases, anxiety, and development: toward or away from threats or rewards? , 2012, Depression and anxiety.

[60]  Jerome Sallet,et al.  Are there specialized circuits for social cognition and are they unique to humans? , 2013, Current Opinion in Neurobiology.

[61]  A. Guyer,et al.  Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience , 2013, Developmental Cognitive Neuroscience.

[62]  E. Leibenluft,et al.  Developmental effects of decision-making on sensitivity to reward: An fMRI study , 2012, Developmental Cognitive Neuroscience.

[63]  E. Crone,et al.  Chronic Childhood Peer Rejection is Associated with Heightened Neural Responses to Social Exclusion During Adolescence , 2015, Journal of Abnormal Child Psychology.

[64]  A. La Greca,et al.  Social Anxiety Among Adolescents: Linkages with Peer Relations and Friendships , 1998, Journal of abnormal child psychology.

[65]  P. Kendall,et al.  Social expectancies and self-perceptions in anxiety-disordered children. , 1997, Journal of anxiety disorders.

[66]  Iroise Dumontheil,et al.  Developmental influences on the neural bases of responses to social rejection: Implications of social neuroscience for education , 2011, NeuroImage.

[67]  C. Sisk,et al.  Pubertal hormones, the adolescent brain, and the maturation of social behaviors: Lessons from the Syrian hamster , 2006, Molecular and Cellular Endocrinology.

[68]  S. Sasagawa,et al.  Developmental Epidemiology of Social Anxiety and Social Phobia in Adolescents , 2015 .

[69]  K. Onoda,et al.  Is dorsal anterior cingulate cortex activation in response to social exclusion due to expectancy violation? An fMRI study , 2012, Front. Evol. Neurosci..

[70]  Carol A. Seger,et al.  The Roles of the Caudate Nucleus in Human Classification Learning , 2005, The Journal of Neuroscience.

[71]  D. Pine,et al.  Neural responses to peer rejection in anxious adolescents , 2012, International journal of behavioral development.

[72]  R. Kessler,et al.  Social fears and social phobia in a community sample of adolescents and young adults: prevalence, risk factors and co-morbidity , 1999, Psychological Medicine.

[73]  Danielle Z. Bolling,et al.  Development of neural systems for processing social exclusion from childhood to adolescence. , 2011, Developmental science.

[74]  Michael X. Cohen,et al.  Striatum-medial prefrontal cortex connectivity predicts developmental changes in reinforcement learning. , 2012, Cerebral cortex.

[75]  Gregory Camilli,et al.  Handbook of Complementary Methods in Education Research , 2018 .

[76]  Russell A. Poldrack,et al.  A unique adolescent response to reward prediction errors , 2010, Nature Neuroscience.

[77]  E. Leibenluft,et al.  Early childhood social reticence and neural response to peers in preadolescence predict social anxiety symptoms in midadolescence , 2019, Depression and anxiety.