Prospects for the Use of Intranasally Administered Insulin and Insulin-Like Growth Factor-1 in Cerebral Ischemia

[1]  W. Wang,et al.  Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions , 2022, Signal Transduction and Targeted Therapy.

[2]  A. Shpakov,et al.  Insulin and Brain Gangliosides Prevent Metabolic Disorders Caused by Activation of Free Radical Reactions after Two-Vessel Ischemia–Reperfusion Injury to the Rat Forebrain , 2022, Journal of Evolutionary Biochemistry and Physiology.

[3]  A. Shpakov,et al.  Insulin and Brain Gangliosides Prevent Metabolic Disorders Caused by Activation of Free Radical Reactions after Two-Vessel Ischemia–Reperfusion Injury to the Rat Forebrain , 2022, Journal of Evolutionary Biochemistry and Physiology.

[4]  Yuan Zhu,et al.  Intranasal insulin ameliorates neurological impairment after intracerebral hemorrhage in mice , 2021, Neural regeneration research.

[5]  A. Shpakov,et al.  Insulin and α-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury , 2021, International journal of molecular sciences.

[6]  C. Kahn,et al.  Insulin action at a molecular level – 100 years of progress , 2021, Molecular metabolism.

[7]  J. Levenga,et al.  Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT’s Role in Complex Brain Disorders and Neurological Disease , 2021, Cerebral cortex communications.

[8]  G. Dodd,et al.  Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis , 2021, Journal of neuroendocrinology.

[9]  A. Ahmadiani,et al.  Intranasal insulin improves mitochondrial function and attenuates motor deficits in a rat 6‐OHDA model of Parkinson's disease , 2021, CNS neuroscience & therapeutics.

[10]  Ling Wei,et al.  Combinatorial intranasal delivery of bone marrow mesenchymal stem cells and insulin-like growth factor-1 improves neurovascularization and functional outcomes following focal cerebral ischemia in mice , 2020, Experimental Neurology.

[11]  Chongyang Zhang,et al.  Updates of Recent Vinpocetine Research in Treating Cardiovascular Diseases , 2020, Journal of cellular immunology.

[12]  H. Wahab,et al.  Insights into the neuropathology of cerebral ischemia and its mechanisms , 2020, Reviews in the neurosciences.

[13]  N. Ashpole,et al.  Loss of insulin‐like growth factor‐1 signaling in astrocytes disrupts glutamate handling , 2019, Journal of neurochemistry.

[14]  A. Shpakov,et al.  Regulatory Effects of Intranasal C-peptide and Insulin on Thyroid and Androgenic Status of Male Rats with Moderate Type 1 Diabetes Mellitus , 2019, Journal of Evolutionary Biochemistry and Physiology.

[15]  I. Zorina,et al.  Effect of Insulin on Lipid Peroxidation and Glutathione Levels in a Two-Vessel Occlusion Model of Rat Forebrain Ischemia Followed by Reperfusion , 2019, Journal of Evolutionary Biochemistry and Physiology.

[16]  C. Mitchell,et al.  Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. , 2019, Cell reports.

[17]  G. Perozziello,et al.  Key Role of Cytochrome C for Apoptosis Detection Using Raman Microimaging in an Animal Model of Brain Ischemia with Insulin Treatment , 2019, Applied spectroscopy.

[18]  W. Banks,et al.  Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance , 2019, Front. Neurosci..

[19]  L. Fan,et al.  Rapid transport of insulin to the brain following intranasal administration in rats , 2019, Neural regeneration research.

[20]  M. Lewitt,et al.  The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System , 2019, Biochemistry insights.

[21]  A. Shpakov,et al.  The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect , 2019, PloS one.

[22]  T. Davis,et al.  Distribution of insulin in trigeminal nerve and brain after intranasal administration , 2019, Scientific Reports.

[23]  C. Kahn,et al.  Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior , 2019, Proceedings of the National Academy of Sciences.

[24]  J. McArthur,et al.  Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice , 2019, AIDS.

[25]  BIOMEMBRANES 2018 , 2018, Journal of Bioenergetics and Biomembranes.

[26]  L. Yao,et al.  PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia , 2018, Molecular medicine reports.

[27]  K. Schindowski,et al.  Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa , 2018, Pharmaceutics.

[28]  I. Zorina,et al.  Insulin Administration Prevents Accumulation of Conjugated Dienes and Trienes and Inactivation of Na+, K+-ATPase in the Rat Cerebral Cortex during Two-Vessel Forebrain Ischemia and Reperfusion , 2018, Journal of Evolutionary Biochemistry and Physiology.

[29]  N. Barzilai,et al.  40 YEARS of IGF1 IGF1: the Jekyll and Hyde of the aging brain , 2018 .

[30]  Oren Hr.  Review of "ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin) A Randomized Controlled Trial to Assess the Efficacy of Actovegin in Poststroke Cognitive Impairment" , 2018 .

[31]  A. Shpakov,et al.  The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents , 2018, Neurochemical Research.

[32]  W. Freeman,et al.  Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes , 2018, Molecular metabolism.

[33]  C. Dispenza,et al.  Nose‐to‐brain delivery of insulin enhanced by a nanogel carrier , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[34]  Abigail K. Brown,et al.  Regulation of FOXO Factors in Mammalian Cells. , 2018, Current topics in developmental biology.

[35]  Ó. Escribano,et al.  The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications , 2017, Journal of diabetes research.

[36]  R. Vasan,et al.  Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study , 2017, Stroke.

[37]  A. Shpakov,et al.  Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome , 2017, Bulletin of Experimental Biology and Medicine.

[38]  A. Guekht,et al.  ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin) , 2017, Stroke.

[39]  A. Toker,et al.  AKT/PKB Signaling: Navigating the Network , 2017, Cell.

[40]  W. Winlow,et al.  Pathogenic mechanisms following ischemic stroke , 2017, Neurological Sciences.

[41]  D. Tropea,et al.  Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging , 2017, Front. Cell. Neurosci..

[42]  T. Nishijima,et al.  Circulating Insulin-Like Growth Factor I Regulates Its Receptor in the Brain of Male Mice , 2016, Endocrinology.

[43]  O. V. Chistyakova,et al.  Functional state of hypothalamic signaling systems in rats with type 2 diabetes mellitus treated with intranasal insulin , 2016, Journal of Evolutionary Biochemistry and Physiology.

[44]  S. Craft,et al.  The role of insulin in the vascular contributions to age-related dementia. , 2016, Biochimica et biophysica acta.

[45]  V. Lioutas,et al.  Intranasal insulin neuroprotection in ischemic stroke , 2016, Neural regeneration research.

[46]  Jiguang Wang,et al.  Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study , 2016, Stroke.

[47]  Paul M. George,et al.  Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments , 2015, Neuron.

[48]  V. Lioutas,et al.  Intranasal Insulin and Insulin-Like Growth Factor 1 as Neuroprotectants in Acute Ischemic Stroke , 2015, Translational Stroke Research.

[49]  A. Shpakov,et al.  Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases , 2015, Future science OA.

[50]  Y. Pei,et al.  Insulin Neuroprotection and the Mechanisms , 2015, Chinese medical journal.

[51]  R. Jope,et al.  Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. , 2015, Pharmacology & therapeutics.

[52]  A. Shpakov,et al.  The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats , 2015, Hormone and Metabolic Research.

[53]  F. Haj,et al.  Protein-tyrosine phosphatase 1B substrates and metabolic regulation. , 2015, Seminars in cell & developmental biology.

[54]  An-kang Hu,et al.  The Regulatory Mechanism of Neurogenesis by IGF-1 in Adult Mice , 2015, Molecular Neurobiology.

[55]  P. Sandercock,et al.  Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials | NOVA. The University of Newcastle's Digital Repository , 2014 .

[56]  Y. Day,et al.  Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite , 2014, Journal of Biomedical Science.

[57]  Stephen L. Abrams,et al.  GSK-3 as potential target for therapeutic intervention in cancer , 2014, Oncotarget.

[58]  Y. Day,et al.  The essential role of endothelial nitric oxide synthase activation in insulin-mediated neuroprotection against ischemic stroke in diabetes. , 2014, Journal of vascular surgery.

[59]  T. Sanderson,et al.  Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment , 2013, PloS one.

[60]  R. Muniyappa,et al.  Metabolic actions of angiotensin II and insulin: A microvascular endothelial balancing act , 2013, Molecular and Cellular Endocrinology.

[61]  R. P. Kraig,et al.  Insulin‐like growth factor‐1 abrogates microglial oxidative stress and TNF‐α responses to spreading depression , 2013, Journal of neurochemistry.

[62]  Honglian Shi,et al.  Hyperglycemia as a Risk Factor of Ischemic Stroke , 2013, Journal of drug metabolism & toxicology.

[63]  A. Fischer,et al.  Generating new neurons to circumvent your fears: the role of IGF signaling , 2013, Cellular and Molecular Life Sciences.

[64]  T. Sanderson,et al.  Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation , 2013, Molecular Neurobiology.

[65]  Ali Haeri,et al.  Insulin in the Brain: Sources, Localization and Functions , 2013, Molecular Neurobiology.

[66]  D. Fatovich,et al.  Thrombolysis in acute ischaemic stroke , 2012, The Lancet.

[67]  B. Hemmings,et al.  PI3K-PKB/Akt pathway. , 2012, Cold Spring Harbor perspectives in biology.

[68]  M. White,et al.  Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 , 2012, Diabetologia.

[69]  R. McKnight,et al.  Traumatic brain injury increased IGF-1B mRNA and altered IGF-1 exon 5 and promoter region epigenetic characteristics in the rat pup hippocampus. , 2012, Journal of neurotrauma.

[70]  Y. Samson,et al.  Glucose and Acute Stroke: Evidence for an Interlude , 2012, Stroke.

[71]  P. Moreira,et al.  Insulin in Central Nervous System: More than Just a Peripheral Hormone , 2012, Journal of aging research.

[72]  T. Montine,et al.  Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial , 2011 .

[73]  K. Hsu,et al.  Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways , 2011, Neuropharmacology.

[74]  K. Furie,et al.  Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies , 2011, Stroke.

[75]  J. Guan.  Insulin‐Like Growth Factor ‐1 (IGF‐1) Derived Neuropeptides, a Novel Strategy for the Development of Pharmaceuticals for Managing Ischemic Brain Injury , 2011, CNS neuroscience & therapeutics.

[76]  A. Higazi,et al.  Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

[77]  Michael Nilsson,et al.  Serum IGF-I levels correlate to improvement of functional outcome after ischemic stroke. , 2011, The Journal of clinical endocrinology and metabolism.

[78]  Shuying Lin,et al.  Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia–ischemia , 2011, Brain Research.

[79]  S. Kozma,et al.  Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage , 2011, Proceedings of the National Academy of Sciences.

[80]  B. Vanhaesebroeck,et al.  The emerging mechanisms of isoform-specific PI3K signalling , 2010, Nature Reviews Molecular Cell Biology.

[81]  T. Sanderson,et al.  Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia , 2009, Neurological research.

[82]  Laura Sciacca,et al.  Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. , 2009, Endocrine reviews.

[83]  S. Lipton,et al.  Intranasal delivery of erythropoietin plus insulin-like growth factor-I for acute neuroprotection in stroke. Laboratory investigation. , 2009, Journal of neurosurgery.

[84]  L. Fan,et al.  Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats , 2009, Experimental Neurology.

[85]  G. Semenza,et al.  Regulation of oxygen homeostasis by hypoxia-inducible factor 1. , 2009, Physiology.

[86]  A. Nishiyama,et al.  Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity , 2009, Nature Reviews Neuroscience.

[87]  T. Sanderson,et al.  Insulin blocks cytochrome c release in the reperfused brain through PI3‐K signaling and by promoting Bax/Bcl‐XL binding , 2008, Journal of neurochemistry.

[88]  C. Oliveira,et al.  Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3beta signaling pathways and changes in protein expression. , 2008, Biochimica et biophysica acta.

[89]  K. Gerozissis.  Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. , 2008, European journal of pharmacology.

[90]  P. De Meyts.  The insulin receptor: a prototype for dimeric, allosteric membrane receptors? , 2008, Trends in biochemical sciences.

[91]  M. Kokkoris,et al.  THE BOOK OF ABSTRACTS , 2015 .

[92]  C. Proud,et al.  The mTOR pathway in the control of protein synthesis. , 2006, Physiology.

[93]  J. Rafols,et al.  Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: Effects of insulin and C-peptide , 2006, Brain Research.

[94]  N. Hardingham,et al.  Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability , 2006, The Journal of Neuroscience.

[95]  P. Chan,et al.  Activation of the Akt/GSK3β Signaling Pathway Mediates Survival of Vulnerable Hippocampal Neurons after Transient Global Cerebral Ischemia in Rats , 2006 .

[96]  P. Chan,et al.  Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. , 2006, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[97]  C. Oliveira,et al.  Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses. , 2005, Free radical biology & medicine.

[98]  J. Guan,et al.  Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat , 2005, Neuropeptides.

[99]  K. Blomgren,et al.  IGF‐I neuroprotection in the immature brain after hypoxia‐ischemia, involvement of Akt and GSK3β? , 2005, The European journal of neuroscience.

[100]  V. I. Skvortsova,et al.  [Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency]. , 2005, Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.

[101]  R. Baserga,et al.  Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[102]  Myriam Bernaudin,et al.  HIF1 and oxygen sensing in the brain , 2004, Nature Reviews Neuroscience.

[103]  W. Frey,et al.  The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats. , 2004, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[104]  B. Siesjö,et al.  Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat , 2004, Experimental Brain Research.

[105]  G. Boysen,et al.  The effects of early insulin treatment combined with thrombolysis in rat embolic stroke , 2002, Neurological research.

[106]  M. White,et al.  Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* , 2002, The Journal of Biological Chemistry.

[107]  L. Whittaker,et al.  Alanine Scanning Mutagenesis of a Type 1 Insulin-like Growth Factor Receptor Ligand Binding Site* , 2001, The Journal of Biological Chemistry.

[108]  H. Gerstein,et al.  Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview , 2001, Stroke.

[109]  William H. Frey,et al.  Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion , 2001, Neuroscience Letters.

[110]  W. Frey,et al.  Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage , 2001, Journal of the Neurological Sciences.

[111]  J. Phillis,et al.  The effect of intravenous insulin on accumulation of excitotoxic and other amino acids in the ischemic rat cerebral cortex , 2000, Neuroscience Letters.

[112]  S. Sciacchitano,et al.  Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. , 2000, Molecular endocrinology.

[113]  M. Moskowitz,et al.  Pathobiology of ischaemic stroke: an integrated view , 1999, Trends in Neurosciences.

[114]  Frank X. Zhang,et al.  N-Methyl-d-aspartate Inhibits Apoptosis through Activation of Phosphatidylinositol 3-Kinase in Cerebellar Granule Neurons , 1998, The Journal of Biological Chemistry.

[115]  P. Gluckman,et al.  Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury. , 1998, Brain research. Molecular brain research.

[116]  S. Kuroda,et al.  Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion , 1998, Experimental Brain Research.

[117]  B. Siesjö,et al.  Extracellular potassium in a neocortical core area after transient focal ischemia. , 1997, Stroke.

[118]  R. Hester,et al.  Role of nitric oxide, adenosine, and ATP-sensitive potassium channels in insulin-induced vasodilation. , 1996, Hypertension.

[119]  B. Tranmer,et al.  Insulin reduction of cerebral infarction due to transient focal ischemia. , 1995, Journal of neurosurgery.

[120]  D. S. Zahm,et al.  Insulin gene expression and insulin synthesis in mammalian neuronal cells. , 1994, The Journal of biological chemistry.

[121]  C. Z. Zhu,et al.  Intraventricular Administration of Insulin and IGF-1 in Transient Forebrain Ischemia , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[122]  D. Beju,et al.  Immunohistochemical and in situ hybridization study of an insulin-like substance in fetal neuron cell cultures , 1994, Brain Research.

[123]  S. Devaskar,et al.  Insulin II gene expression in rat central nervous system , 1993, Regulatory Peptides.

[124]  M. Gunning,et al.  The Effects of IGF-1 Treatment after Hypoxic-Ischemic Brain Injury in Adult Rats , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[125]  M. Todd,et al.  Insulin‐Induced Normoglycemia Improves Ischemic Outcome in Hyperglycemic Rats , 1992, Stroke.

[126]  J. Seylaz,et al.  Insulin protects brain tissue against focal ischemia in rats , 1992, Neuroscience Letters.

[127]  J. Storm-Mathisen,et al.  Chapter 19: Ultrastructural immunocytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue , 1992 .

[128]  R. Auer,et al.  Insulin Attenuates Ischemic Brain Damage Independent of its Hypoglycemic Effect , 1991, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[129]  I. Whishaw,et al.  Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. , 1989, Stroke.

[130]  J. Tew,et al.  Effect of insulin on acute experimental cerebral ischemia in gerbils. , 1989, Stroke.

[131]  JVázquez-Cruz,et al.  Effect of insulin on acute experimental cerebral ischemia in gerbils. , 1989 .

[132]  R. Auer,et al.  The effect of postischemic blood glucose levels on ischemic brain damage in the rat , 1988, Annals of neurology.

[133]  J. Milbrandt,et al.  Differential expression of insulin-like growth factor genes in rat central nervous system. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[134]  M. Brownstein,et al.  Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. , 1979, The Journal of clinical investigation.

[135]  M. Brownstein,et al.  Insulin receptors are widely distributed in the central nervous system of the rat , 1978, Nature.

[136]  E. Melamed.  Reactive hyperglycaemia in patients with acute stroke , 1976, Journal of the Neurological Sciences.