Centric slider-crank mechanism forms the main mechanism of slider-crank type cluster well pumping unit (SCTCWPU). The kinematic analysis is the basis of structure design of SCTCWPU. The kinematic analysis based on Pro/Mechanism is simple, intuitive ,reliable,accurate and easy to be modify. This paper presents the mechanism kinematics simulation of SCTCWPU based on Pro/Mechanism. In addition,a comparative motion analysis of SCTCWPU in Pro/Mechanism and MATLAB is made on the basis of actual working conditions.