Emergence of echovirus type 13 as a prominent enterovirus.

In 2001, increased activity of the rarely detected enterovirus echovirus type 13 (E13) was observed in the United States. This article describes the epidemiologic, clinical, and genetic characteristics of E13 activity in the United States in 2001, compared with E13 activity abroad in 2000-2002. In the United States, E13 accounted for 376 (24%) of the 1584 enterovirus isolates reported in 2001 (29% of the reported isolates had a known serotype), compared with 74 isolates reported during 1970-2000. Five states reported aseptic meningitis outbreaks associated with E13, for a total of 521 cases. All characterized E13 isolates from the United States, Europe, Asia, and Oceania recovered in 2000-2002 were at least 95% identical to each other in VP1 capsid gene sequence, but they were genetically distinct from E13 isolates recovered before 2000. Continued surveillance of enteroviruses is important to alert physicians and public health officials to changes in disease trends and to improve efficiencies of clinical intervention.

[1]  J. Lovchik,et al.  Aseptic Meningitis Epidemic during a West Nile Virus Avian Epizootic , 2003, Emerging infectious diseases.

[2]  P. Lemey,et al.  Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000 , 2003, Journal of medical virology.

[3]  A. Tenório,et al.  First epidemic of aseptic meningitis due to echovirus type 13 among Spanish children , 2003, Epidemiology and Infection.

[4]  B. Lina,et al.  Three ECHOvirus Serotypes Responsible for Outbreak of Aseptic Meningitis in Rhône-Alpes Region, France , 2003, European Journal of Clinical Microbiology and Infectious Diseases.

[5]  A. Bruu,et al.  Enteroviruses: Polioviruses, Coxsackieviruses, Echoviruses and Newer Enteroviruses , 2003 .

[6]  M. Pallansch,et al.  Molecular epidemiology and type-specific detection of echovirus 11 isolates from the Americas, Europe, Africa, Australia, southern Asia and the Middle East. , 2003, Virus research.

[7]  W. Schaffner,et al.  Outbreak of aseptic meningitis associated with echovirus 13 , 2002, The Pediatric infectious disease journal.

[8]  Enterovirus surveillance--United States, 2000-2001. , 2002, MMWR. Morbidity and mortality weekly report.

[9]  M. Pallansch,et al.  Type-Specific Detection of Echovirus 30 Isolates Using Degenerate Reverse Transcriptase PCR Primers , 2001, Journal of Clinical Microbiology.

[10]  J. R. Romero,et al.  Pleconaril: a novel antipicornaviral drug , 2001, Expert opinion on investigational drugs.

[11]  Ph. D. Michele D. Renshaw Erica R. Shaver,et al.  Echovirus type 13--United States, 2001. , 2001, MMWR. Morbidity and mortality weekly report.

[12]  B. Twisselmann.  Cluster of cases of viral meningitis caused by echovirus type 13 in Germany , 2000 .

[13]  M. Pallansch,et al.  Comparison of Classic and Molecular Approaches for the Identification of Untypeable Enteroviruses , 2000, Journal of Clinical Microbiology.

[14]  Enterovirus surveillance--United States, 1997-1999. , 2000, MMWR. Morbidity and mortality weekly report.

[15]  Viral meningitis associated with increase in echovirus type 13. , 2000, Communicable disease report. CDR weekly.

[16]  M. Pallansch,et al.  Molecular Epidemiology and Genetic Diversity of Echovirus Type 30 (E30): Genotypes Correlate with Temporal Dynamics of E30 Isolation , 1999, Journal of Clinical Microbiology.

[17]  M. Pallansch,et al.  Molecular Epidemiology and Evolution of Enterovirus 71 Strains Isolated from 1970 to 1998 , 1999, Journal of Virology.

[18]  J. Melnick.  Poliovirus and Other Enteroviruses , 1997 .

[19]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[20]  P. Lin,et al.  Oligonucleotides Containing Degenerate Bases , 1994 .

[21]  P. Lin,et al.  Oligonucleotides containing degenerate bases. Synthesis and uses. , 1994, Methods in molecular biology.

[22]  R. F. Weaver,et al.  Structural comparison of the Autographa californica nuclear polyhedrosis virus-induced RNA polymerase and the three nuclear RNA polymerases from the host, Spodoptera frugiperda. , 1991, Virus research.

[23]  M. Pallansch,et al.  Detection and identification of vaccine-related polioviruses by the polymerase chain reaction. , 1991, Virus research.

[24]  L. Anderson,et al.  Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. , 1986, The Journal of infectious diseases.

[25]  M. Moore,et al.  Centers for Disease Control. Enteroviral disease in the United States, 1970-1979. , 1982, The Journal of infectious diseases.

[26]  C. Hooft,et al.  CLINICAL FINDINGS DURING AN ECHO VIRUS TYPE 13 ENDEMIC INFECTION. , 1963, Helvetica paediatrica acta.

[27]  W. Hammon,et al.  ECHO virus type 13. II. Epidemiologic aspects and clinical associations. , 1961, The American journal of tropical medicine and hygiene.