Detection of brain activation using oxygenation sensitive functional spectroscopy

A nonwater‐suppressed localized spectroscopy experiment using the PRESS‐sequence has been used to study the signal changes of the water resonance during cortical activation. Significant effects with an effect‐to‐noise ratio up to 50:1 for a single shot experiment have been observed upon photic stimulation. The exceedingly high signal‐to‐noise ratio of the experiment was used to demonstrate signal changes as low as 0.1% after electrical stimulation of the median nerve.