Synthesis, evaluation of anti-breast cancer activity in vitro of ICS II derivatives and summary of the structure-activity relationship.

[1]  R. Guan,et al.  A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury , 2021, Andrology.

[2]  H. Hua,et al.  Discovery of β-carboline-(phenylsulfonyl)furoxan hybrids as potential anti-breast cancer agents. , 2021, Bioorganic & medicinal chemistry letters.

[3]  Yanfang Zhao,et al.  Designing, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety. , 2020, Bioorganic & medicinal chemistry letters.

[4]  Jian Zhang,et al.  Effect of Icariside II and Metformin on Penile Erectile Function, Histological Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction , 2020, Sexual medicine.

[5]  K. Thakur,et al.  Icariside II suppresses cervical cancer cell migration through JNK modulated matrix metalloproteinase-2/9 inhibition in vitro and in vivo. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[6]  J. Tabernero,et al.  Enhancing global access to cancer medicines , 2020, CA: a cancer journal for clinicians.

[7]  Wei-xing Zhang,et al.  Icariside II facilitates the differentiation of ADSCs to schwann cells and restores erectile dysfunction through regulation of miR-33/GDNF axis. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  K. Thakur,et al.  Icariside II Inhibits Tumorigenesis via Inhibiting AKT/Cyclin E/ CDK 2 Pathway and Activating Mitochondria-Dependent Pathway. , 2019, Pharmacological research.

[9]  J. Weng,et al.  Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5 , 2019, PloS one.

[10]  Eric P. Winer,et al.  Breast Cancer Treatment: A Review , 2019, JAMA.

[11]  Yuanyuan Deng,et al.  Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats , 2018, Front. Pharmacol..

[12]  Tong Zhang,et al.  Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents , 2018, Molecules.

[13]  M. Xie,et al.  Icarisid II inhibits the proliferation of human osteosarcoma cells by inducing apoptosis and cell cycle arrest , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[14]  A. Harvey,et al.  The re-emergence of natural products for drug discovery in the genomics era , 2015, Nature Reviews Drug Discovery.

[15]  Jinhua Xu,et al.  Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells. , 2015, Molecular medicine reports.

[16]  Zhenhai Zhang,et al.  Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. , 2012, Chemico-biological interactions.

[17]  M. Grever,et al.  Potential of plant-derived natural products in the treatment of leukemia and lymphoma. , 2010, Current drug targets.

[18]  C. Humblet,et al.  Escape from flatland: increasing saturation as an approach to improving clinical success. , 2009, Journal of medicinal chemistry.

[19]  H. Ke,et al.  Multiple Conformations of Phosphodiesterase-5 , 2006, Journal of Biological Chemistry.

[20]  W. Gradishar,et al.  Hormonal therapy for primary breast cancer: Scientific rationale and status of clinical research , 2005, Current oncology reports.