Policy and Science for Global Health Security: Shaping the Course of International Health

The global burden of infectious diseases and the increased attention to natural, accidental, and deliberate biological threats has resulted in significant investment in infectious disease research. Translating the results of these studies to inform prevention, detection, and response efforts often can be challenging, especially if prior relationships and communications have not been established with decision-makers. Whatever scientific information is shared with decision-makers before, during, and after public health emergencies is highly dependent on the individuals or organizations who are communicating with policy-makers. This article briefly describes the landscape of stakeholders involved in information-sharing before and during emergencies. We identify critical gaps in translation of scientific expertise and results, and biosafety and biosecurity measures to public health policy and practice with a focus on One Health and zoonotic diseases. Finally, we conclude by exploring ways of improving communication and funding, both of which help to address the identified gaps. By leveraging existing scientific information (from both the natural and social sciences) in the public health decision-making process, large-scale outbreaks may be averted even in low-income countries.

[1]  Lisa M. Lee,et al.  Strengthening Global Public Health Surveillance through Data and Benefit Sharing , 2018, Emerging Infectious Diseases.

[2]  Sin Nombre hantavirus decreases survival of male deer mice , 2012, Oecologia.

[3]  David L. Smith,et al.  Mapping the zoonotic niche of Ebola virus disease in Africa , 2014, eLife.

[4]  Angellar Manguvo,et al.  The impact of traditional and religious practices on the spread of Ebola in West Africa: time for a strategic shift , 2015, The Pan African medical journal.

[5]  B. Häsler,et al.  Knowledge integration in One Health policy formulation, implementation and evaluation , 2018, Bulletin of the World Health Organization.

[6]  Dale L. Anderson,et al.  Ecological dynamics of emerging bat virus spillover , 2015, Proceedings of the Royal Society B: Biological Sciences.

[7]  Olga Wilhelmi,et al.  On the Seasonal Occurrence and Abundance of the Zika Virus Vector Mosquito Aedes Aegypti in the Contiguous United States , 2016, PLoS currents.

[8]  C. Nunn,et al.  Integrative approaches to the study of primate infectious disease: implications for biodiversity conservation and global health. , 2008, American journal of physical anthropology.

[9]  J. A. Comer,et al.  A novel coronavirus associated with severe acute respiratory syndrome. , 2003, The New England journal of medicine.

[10]  Successes and failures: Worldwide vaccine development and application. , 2010, Biologicals : journal of the International Association of Biological Standardization.

[11]  M E Woolhouse,et al.  Risk factors for human disease emergence. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[12]  Carolina dos S. Ribeiro,et al.  Threats to timely sharing of pathogen sequence data , 2018, Science.

[13]  S. Kippax Understanding and integrating the structural and biomedical determinants of HIV infection: a way forward for prevention , 2008, Current opinion in HIV and AIDS.

[14]  M. Schwartz,et al.  Achieving Conservation Science that Bridges the Knowledge–Action Boundary , 2013, Conservation biology : the journal of the Society for Conservation Biology.

[15]  E. Holmes,et al.  Pandemics: spend on surveillance, not prediction , 2018, Nature.

[16]  J. Childs,et al.  Long-term studies of hantavirus reservoir populations in the southwestern United States: a synthesis. , 1999, Emerging infectious diseases.

[17]  Dylan B. George,et al.  Model-guided fieldwork: practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics , 2012, Ecology letters.

[18]  A. Peterson,et al.  Ecologic and Geographic Distribution of Filovirus Disease , 2004, Emerging infectious diseases.

[19]  Barbara A. Han,et al.  Undiscovered Bat Hosts of Filoviruses , 2016, PLoS neglected tropical diseases.

[20]  Nick Golding,et al.  Mapping the zoonotic niche of Marburg virus disease in Africa , 2015, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[21]  Forum on Medical,et al.  Visit the National Academies Press Online and Register For... Frontiers in Massive Data Analysis , 2022 .

[22]  Y. Guan,et al.  Coronavirus as a possible cause of severe acute respiratory syndrome , 2003, The Lancet.

[23]  Christian Drosten,et al.  Identification of a novel coronavirus in patients with severe acute respiratory syndrome. , 2003, The New England journal of medicine.

[24]  Ibón Cancio Uriarte,et al.  The Nagoya protocol , 2018 .

[25]  Paul Richards,et al.  Social Pathways for Ebola Virus Disease in Rural Sierra Leone, and Some Implications for Containment , 2015, PLoS neglected tropical diseases.

[26]  Christian Drosten,et al.  Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome , 2003, Science.

[27]  B. Greenwood The contribution of vaccination to global health: past, present and future , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[28]  J. Glynn,et al.  Open access policy , 2013, The Lancet.

[29]  C. Pell,et al.  Socio-Cultural Aspects of Chagas Disease: A Systematic Review of Qualitative Research , 2013, PLoS neglected tropical diseases.

[30]  Samuel V. Scarpino,et al.  Modelling the trajectory of disease outbreaks works , 2018, Nature.

[31]  C. Whitty What makes an academic paper useful for health policy? , 2015, BMC Medicine.

[32]  G. Rodier,et al.  Global Public Health Security , 2007, Emerging infectious diseases.

[33]  J. Medlock,et al.  Strategies for containing Ebola in West Africa , 2014, Science.

[34]  M. Christopher One health, one literature: Weaving together veterinary and medical research , 2015, Science Translational Medicine.

[35]  Wenbiao Hu,et al.  Role of big data in the early detection of Ebola and other emerging infectious diseases. , 2015, The Lancet. Global health.

[36]  E. Walsh,et al.  Novel coronavirus and severe acute respiratory syndrome , 2003, The Lancet.

[37]  Ebenezer K. Badu,et al.  Human–Bat Interactions in Rural West Africa , 2015, Emerging infectious diseases.

[38]  Jantien A. Backer,et al.  Spatiotemporal Analysis of the 2014 Ebola Epidemic in West Africa , 2016, PLoS Comput. Biol..

[39]  Kavita M. Berger,et al.  National and Transnational Security Implications of Asymmetric Access to and Use of Biological Data , 2019, Front. Bioeng. Biotechnol..

[40]  G. Rodier,et al.  Social and cultural factors behind community resistance during an Ebola outbreak in a village of the Guinean Forest region, February 2015: a field experience. , 2016, International health.

[41]  Dylan B. George,et al.  Mathematical modeling of the West Africa Ebola epidemic , 2015, eLife.

[42]  Maria De Bruyn,et al.  Women and aids in developing countries: The XIIth international conference on the social sciences and medicine , 1992 .

[43]  P. Mabry,et al.  Interdisciplinarity and systems science to improve population health: a view from the NIH Office of Behavioral and Social Sciences Research. , 2008, American journal of preventive medicine.

[44]  Junhua Li,et al.  Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4. , 2011, The New England journal of medicine.

[45]  J. Chermann,et al.  Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). , 1983, Science.

[46]  J. Morgan,et al.  Global Health Security Implementation: Expanding the Evidence Base. , 2018, Health security.

[47]  R. Evans European Centre for Disease Prevention and Control. , 2014, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[48]  J. Wood,et al.  Facility-based surveillance for emerging infectious diseases; diagnostic practices in rural West African hospital settings: observations from Ghana , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

[49]  R. Kasimanickam,et al.  Emerging Infectious Diseases, Antimicrobial Resistance and Millennium Development Goals: Resolving the Challenges through One Health , 2013, Central Asian journal of global health.

[50]  Kate E. Jones,et al.  A framework for the study of zoonotic disease emergence and its drivers: spillover of bat pathogens as a case study , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

[51]  Pejman Rohani,et al.  Avoidable errors in the modelling of outbreaks of emerging pathogens, with special reference to Ebola , 2014, Proceedings of the Royal Society B: Biological Sciences.

[52]  D. Yach,et al.  Global health security: the wider lessons from the west African Ebola virus disease epidemic , 2015, The Lancet.

[53]  B. Greenwood,et al.  Vaccines and global health , 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

[54]  D. Lazer,et al.  The Parable of Google Flu: Traps in Big Data Analysis , 2014, Science.

[55]  F. Leendertz,et al.  Wild great apes as sentinels and sources of infectious disease. , 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[56]  P. Daszak,et al.  Prediction and prevention of the next pandemic zoonosis , 2012, The Lancet.

[57]  P. Rollin,et al.  Perspectives on West Africa Ebola Virus Disease Outbreak, 2013–2016 , 2016, Emerging infectious diseases.

[58]  J. Rowcliffe,et al.  Uncovering the fruit bat bushmeat commodity chain and the true extent of fruit bat hunting in Ghana, West Africa , 2011, Biological conservation.

[59]  Malik Peiris,et al.  Koch's postulates fulfilled for SARS virus , 2003, Nature.

[60]  A Mawudeku,et al.  Big Data and the Global Public Health Intelligence Network (GPHIN). , 2015, Canada communicable disease report = Releve des maladies transmissibles au Canada.

[61]  Kate E. Jones,et al.  Quantifying Global Drivers of Zoonotic Bat Viruses: A Process-Based Perspective , 2016, The American Naturalist.

[62]  G Krause,et al.  Large and ongoing outbreak of haemolytic uraemic syndrome, Germany, May 2011. , 2011, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[63]  N. Wareham,et al.  A translational framework for public health research , 2009, BMC public health.

[64]  J. Mills,et al.  Species diversity concurrently dilutes and amplifies transmission in a zoonotic host–pathogen system through competing mechanisms , 2018, Proceedings of the National Academy of Sciences.

[65]  D. KennedyErin,et al.  Global Health Security Implementation: Expanding the Evidence Base , 2018 .

[66]  Meggan E Craft,et al.  “One Health” or Three? Publication Silos Among the One Health Disciplines , 2016, PLoS biology.

[67]  S. Morse,et al.  Opinion: Specimen collections should have a much bigger role in infectious disease research and response , 2016, Proceedings of the National Academy of Sciences.

[68]  Peter Sands,et al.  The Neglected Dimension of Global Security--A Framework for Countering Infectious-Disease Crises. , 2016, The New England journal of medicine.

[69]  Jing Jin,et al.  Factors affecting therapeutic compliance: A review from the patient’s perspective , 2008, Therapeutics and clinical risk management.

[70]  Sudhir Kumar Jain,et al.  Towards global health security: response to the May 2018 Nipah virus outbreak linked to Pteropus bats in Kerala, India , 2018, BMJ Global Health.

[71]  D. Hayman Biannual birth pulses allow filoviruses to persist in bat populations , 2015, Proceedings of the Royal Society B: Biological Sciences.

[72]  P. Ulin,et al.  African women and AIDS: negotiating behavioral change. , 1992, Social science & medicine.

[73]  J. Rowcliffe,et al.  Characteristics and Risk Perceptions of Ghanaians Potentially Exposed to Bat-Borne Zoonoses through Bushmeat , 2014, EcoHealth.