THE ANERGY OF ANNULARITY

We explain the types and historical studies of annular and arciform lesions. In addition, we present a study of annular lesions on a patient with Erythema Annulare Centrifugum (EAC), proven to be caused by a delayed type hypersensitivity (DTH) to trichophyton antigen, using monoclonal antibodies to identify subsets of tissue monocytes outside the EAC lesion, in the inflamed border of the same EAC lesion and inside the circle (anergic area) of the same EAC lesion. Macrophages (M), Langerhans' cells (LC), pan‐T cells, and the T cell subsets of helper/inducer T cells, suppressor/cytotoxic T cells, activated T cells and Ia (HLA‐immune associated) T cells were identified, localized, and compared in the respective areas of the annular lesion.