Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri.

[1]  R. Abagyan,et al.  CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM) , 2017, PLoS neglected tropical diseases.

[2]  A. Debnath,et al.  Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri , 2017, PLoS neglected tropical diseases.

[3]  A. Harris,et al.  Diagnosis, Clinical Course, and Treatment of Primary Amoebic Meningoencephalitis in the United States, 1937-2013. , 2015, Journal of the Pediatric Infectious Diseases Society.

[4]  G. Cabral,et al.  Identification of Peptidases in Highly Pathogenic vs. Weakly Pathogenic Naegleria fowleri Amebae , 2015, The Journal of eukaryotic microbiology.

[5]  Sun Park,et al.  Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory–secretory proteins and their biochemical properties , 2014, Parasitology Research.

[6]  J. Cope.  Investigational Drug Available Directly from CDC for the Treatment of Infections with Free-Living Amebae , 2013, MMWR. Morbidity and mortality weekly report.

[7]  T. Moore,et al.  Primary amebic meningoencephalitis deaths associated with sinus irrigation using contaminated tap water. , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  P. Gautam,et al.  A rare case of survival from primary amebic meningoencephalitis , 2012, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

[9]  D. A. A. El-Maaty,et al.  Primary Amoebic Meningoencephalitis Caused By Naegleria Fowleri , 2012 .

[10]  J. Jonckheere.  Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri. , 2011 .

[11]  M. Beg,et al.  Primary Amebic Meningoencephalitis Caused by Naegleria fowleri, Karachi, Pakistan , 2011, Emerging infectious diseases.

[12]  J. D. de Jonckheere.  Origin and evolution of the worldwide distributed pathogenic amoeboflagellate Naegleria fowleri. , 2011, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

[13]  G. Visvesvara.  Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment* , 2010, Current opinion in infectious diseases.

[14]  P. Dorrestein,et al.  A Novel Entamoeba histolytica Cysteine Proteinase, EhCP4, Is Key for Invasive Amebiasis and a Therapeutic Target* , 2010, The Journal of Biological Chemistry.

[15]  M. Beach,et al.  The epidemiology of primary amoebic meningoencephalitis in the USA, 1962–2008 , 2009, Epidemiology and Infection.

[16]  Conor R. Caffrey,et al.  A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition*S⃞ , 2008, Journal of Biological Chemistry.

[17]  V. Tsutsumi,et al.  Characterization of brain inflammation during primary amoebic meningoencephalitis. , 2008, Parasitology international.

[18]  V. Tsutsumi,et al.  A Biochemical Comparison of Proteases from Pathogenic Naegleria fowleri and Non‐Pathogenic Naegleria gruberi , 2007, The Journal of eukaryotic microbiology.

[19]  F. Schuster,et al.  Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. , 2007, FEMS immunology and medical microbiology.

[20]  Adam R Renslo,et al.  Drug discovery and development for neglected parasitic diseases , 2006, Nature chemical biology.

[21]  William R. Roush,et al.  Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones , 2003, Antimicrobial Agents and Chemotherapy.

[22]  J. McKerrow,et al.  Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. , 2001, Bioorganic & medicinal chemistry letters.

[23]  S. L. Gwaltney,et al.  Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases , 1998 .

[24]  K. Aldape,et al.  Naegleria fowleri: characterization of a secreted histolytic cysteine protease. , 1994, Experimental parasitology.

[25]  G. Visvesvara,et al.  Epidemiology of free-living ameba infections. , 1990, The Journal of protozoology.