Expression of glucose transporter‐1 in human gastric carcinoma

Malignant cells show increased glucose uptake in vitro and in vivo, which is believed to be facilitated by glucose transporters (Gluts). Expression of Glut1, one of the Gluts, has been described in malignancies of the esophagus, colon, pancreas, lung, and brain, but to the authors' knowledge the significance of Glut1 expression in human gastric carcinoma has not been elucidated. The objective of the current study was to examine the expression and distribution of Glut1 and its relation to clinicopathologic parameters in patients with gastric carcinoma.

[1]  M. Mihm,et al.  GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. , 2000, Human pathology.

[2]  S. Satoh,et al.  Glucose transporter expression in developing fetal lungs and lung neoplasms. , 1999, Histology and histopathology.

[3]  R L Wahl,et al.  Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  S. Satoh,et al.  Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage. , 1998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[5]  Mark A. Stephenson,et al.  Overexpression of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival , 1997, Cancer.

[6]  H. Inoue,et al.  Glucose‐transporter‐type‐I‐gene amplification correlates with Sialyl‐Lewis‐X synthesis and proliferation in lung cancer , 1997, International journal of cancer.

[7]  M. Younes,et al.  Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[8]  W. Pardridge,et al.  Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. , 1996, The Journal of clinical investigation.

[9]  M. Younes,et al.  Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. , 1996, Cancer research.

[10]  David E. Housman,et al.  Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours , 1996, Nature.

[11]  R. Brown,et al.  GLUT1 expression in human breast carcinoma: correlation with known prognostic markers. , 1995, Anticancer research.

[12]  R L Wahl,et al.  Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[13]  U. Staedt,et al.  Substrate balances across colonic carcinomas in humans. , 1995, Cancer research.

[14]  K. Black,et al.  Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors. , 1994, Brain research. Molecular brain research.

[15]  S. Hauguel-de Mouzon,et al.  Developmental expression of Glut1 glucose transporter and c‐fos genes in human placental cells , 1994, Placenta.

[16]  S. Vannucci,et al.  Glucose transporter proteins in brain , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  D. Flint,et al.  Regulation of the glucose transporter GLUT1 in mammalian cells. , 1994, Biochemical Society transactions.

[18]  M. Mozzoli,et al.  Glucose Transporter Proteins in Human Insulinoma , 1994, Annals of Internal Medicine.

[19]  M. Mueckler Facilitative glucose transporters. , 1994, European journal of biochemistry.

[20]  M. Palacín,et al.  High and polarized expression of GLUT1 glucose transporters in epithelial cells from mammary gland: acute down-regulation of GLUT1 carriers by weaning. , 1994, Endocrinology.

[21]  B. Swartz,et al.  The Human Brain GLUT1 Glucose Transporter: Ultrastructural Localization to the Blood—Brain Barrier Endothelia , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  T. Jansson,et al.  Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. , 1993, The Journal of clinical endocrinology and metabolism.

[23]  R L Wahl,et al.  An Immunohistochemical Study , 2006 .

[24]  R. Plevin,et al.  Growth factors, mitogens, oncogenes and the regulation of glucose transport. , 1993, Cellular signalling.

[25]  E. Kraegen,et al.  Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4. , 1993, The Biochemical journal.

[26]  D. Mischoulon,et al.  Differential regulation of glucose transporter 1 and 2 mRNA expression by epidermal growth factor and transforming growth factor‐beta in rat hepatocytes , 1992, Journal of cellular physiology.

[27]  R. Shigemoto,et al.  Distribution of the glucose transporters in human brain tumors. , 1992, Cancer research.

[28]  M. Schwaiger,et al.  The relationship between myocardial blood flow and glucose uptake in ischemic canine myocardium determined with fluorine-18-deoxyglucose. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[29]  N. Tallada,et al.  An Immunohistochemical Study , 1992 .

[30]  E. Newsholme,et al.  Application of metabolic-control logic to fuel utilization and its significance in tumor cells. , 1991, Advances in enzyme regulation.

[31]  Kazutomo Inoue,et al.  Over-expression of facilitative glucose transporter genes in human cancer. , 1990, Biochemical and biophysical research communications.

[32]  P. Okunieff,et al.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.

[33]  B. Rollins,et al.  Platelet-derived growth factor regulates glucose transporter expression. , 1988, The Journal of biological chemistry.

[34]  M. Birnbaum,et al.  Growth factors rapidly induce expression of the glucose transporter gene. , 1988, The Journal of biological chemistry.

[35]  Heikki Joensuu,et al.  Florodeoxyglucose imaging: A method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors , 1988 .

[36]  H. Minn,et al.  Fluorodeoxyglucose imaging: a method to assess the proliferative activity of human cancer in vivo. Comparison with DNA flow cytometry in head and neck tumors. , 1988, Cancer.

[37]  H. Lodish,et al.  Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. , 1987, Science.

[38]  M. Birnbaum,et al.  Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[39]  J S Fowler,et al.  Increased accumulation of 2-deoxy-2-[18F]Fluoro-D-glucose in liver metastases from colon carcinoma. , 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[40]  S. Hsu,et al.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. , 1981, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[41]  K. Isselbacher Sugar and amino acid transport by cells in culture--differences between normal and malignant cells. , 1972, The New England journal of medicine.

[42]  K. Isselbacher A medical treatment for gallstones? , 1972, The New England journal of medicine.