alpha-adrenergic coronary vasoconstriction and myocardial ischemia in humans.

The use of quantitative coronary angiography, combined with Doppler and PET, has recently been directed at the study of alpha-adrenergic coronary vasomotion in humans. Confirming prior animal experiments, there is no evidence of alpha-adrenergic coronary constrictor tone at rest. Again confirming prior experiments, responses to alpha-adrenoceptor activation are augmented in the presence of coronary endothelial dysfunction and atherosclerosis, involving both alpha(1)- and alpha(2)-adrenoceptors in epicardial conduit arteries and microvessels. Such augmented alpha-adrenergic coronary constriction is observed during exercise and coronary interventions, and it is powerful enough to induce myocardial ischemia and limit myocardial function. Recent studies indicate a genetic determination of alpha(2)-adrenergic coronary constriction.

[1]  R. Erbel,et al.  G Protein β3 Subunit 825T Allele and Enhanced Coronary Vasoconstriction on α2-Adrenoceptor Activation , 1999 .

[2]  R. Foale,et al.  Effect of α1-Adrenoceptor Blockade on Coronary Vasodilator Reserve in Cardiac Syndrome X , 1999 .

[3]  O. Hess,et al.  Alpha-adrenoceptor blockade prevents exercise-induced vasoconstriction of stenotic coronary arteries. , 1999, Journal of the American College of Cardiology.

[4]  R. Erbel,et al.  Augmented α-Adrenergic Constriction of Atherosclerotic Human Coronary Arteries , 1999 .

[5]  A. Distante,et al.  α-Adrenergic Blockade Improves Recovery of Myocardial Perfusion and Function After Coronary Stenting in Patients With Acute Myocardial Infarction , 1999 .

[6]  A. Distante,et al.  Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction. , 1999, Circulation.

[7]  A. Zanchetti,et al.  Postischemic left ventricular dysfunction is abolished by alpha-adrenergic blocking agents. , 1998, Journal of the American College of Cardiology.

[8]  Arya M. Sharma,et al.  Association of a human G-protein β3 subunit variant with hypertension , 1998, Nature Genetics.

[9]  C. Tiefenbacher,et al.  Requisite role of cardiac myocytes in coronary alpha1-adrenergic constriction. , 1998, Circulation.

[10]  J. Marco,et al.  The alpha-1 adrenergic blocking agent urapidil counteracts postrotational atherectomy "elastic recoil" where nitrates have failed. , 1997, The American journal of cardiology.

[11]  A. Castaigne,et al.  Sympathetic Stimulation Overrides Flow-Mediated Endothelium-Dependent Epicardial Coronary Vasodilation in Transplant Patients , 1996 .

[12]  P. Camici,et al.  Effect of alpha 1-adrenoceptor blockade on resting and hyperemic myocardial blood flow in normal humans. , 1996, The American journal of physiology.

[13]  P. Kaufmann,et al.  Normalization of abnormal coronary vasomotion by calcium antagonists in patients with hypertension. , 1996, Circulation.

[14]  M. Condorelli,et al.  Limb vasoconstriction after successful angioplasty of the left anterior descending coronary artery. , 1995, Circulation.

[15]  A. Zeiher,et al.  Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. , 1995, Circulation.

[16]  A. Castaigne,et al.  Comparison of the effects of exercise and cold pressor test on the vasomotor response of normal and atherosclerotic coronary arteries and their relation to the flow-mediated mechanism. , 1995, American Journal of Cardiology.

[17]  A. Quyyumi,et al.  Sympathetically mediated effects of mental stress on the cardiac microcirculation of patients with coronary artery disease. , 1995, The American journal of cardiology.

[18]  A. Zeiher,et al.  Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. , 1995, Circulation.

[19]  C. Jones,et al.  alpha-adrenergic responses of isolated canine coronary microvessels. , 1995, Basic Research in Cardiology.

[20]  M. Condorelli,et al.  Coronary artery vasoconstriction after successful single angioplasty of the left anterior descending artery. , 1994, American Heart Journal.

[21]  P. Camici,et al.  Role of positron emission tomography in the investigation of human coronary circulatory function. , 1994, Cardiovascular research.

[22]  J. Marco,et al.  Coronary Vasoconstriction After Percutaneous Transluminal Coronary Angioplast Is Attenuated by Antiadrenergic Agents , 1994, Circulation.

[23]  M. Condorelli,et al.  Forearm vascular responsiveness to alpha 1- and alpha 2-adrenoceptor stimulation in patients with congestive heart failure. , 1994, Circulation.

[24]  O. Hess,et al.  Influence of Serum Cholesterol and Other Coronary Risk Factors on Vasomotion of Angiographically Normal Coronary Arteries , 1993, Circulation.

[25]  T. Ehring,et al.  Impact of alpha-adrenergic coronary vasoconstriction on the transmural myocardial blood flow distribution during humoral and neuronal adrenergic activation. , 1993, Circulation research.

[26]  William M. Chilian,et al.  Endothelium‐Dependent Relaxation Competes With &agr;1‐ and &agr;2‐Adrenergic Constriction in the Canine Epicardial Coronary Microcirculation , 1993, Circulation.

[27]  M. Condorelli,et al.  Role of α2‐Adrenoceptors in Normal and Atherosclerotic Human Coronary Circulation , 1992, Circulation.

[28]  E. Picano,et al.  Activation of sympathetic tone during dipyridamole test. , 1992, Chest.

[29]  P. Ganz,et al.  Patients With Evidence of Coronary Endothelial Dysfunction as Assessed by Acetylcholine Infusion Demonstrate Marked Increase in Sensitivit to Constrictor Effects of Catecholamines , 1992, Circulation.

[30]  A. Yeung,et al.  The effect of atherosclerosis on the vasomotor response of coronary arteries to mental stress. , 1991, The New England journal of medicine.

[31]  A. Maseri.  Coronary vasoconstriction: visible and invisible. , 1991, The New England journal of medicine.

[32]  W. Chilian.  Functional distribution of alpha 1- and alpha 2-adrenergic receptors in the coronary microcirculation. , 1991, Circulation.

[33]  H. Drexler,et al.  Endothelial Dysfunction of the Coronary Microvasculature Is Associated With Impaired Coronary Blood Flow Regulation in Patients With Early Atherosclerosis , 1991, Circulation.

[34]  F. Crea,et al.  Abnormal Vasomotor Changes Early After Coronary Angioplasty: A Quantitative Arteriographic Study of Their Time Course , 1991, Circulation.

[35]  Geoffrey Burnstock,et al.  Roles of P2‐Purinoceptors in the Cardiovascular System , 1991, Circulation.

[36]  H. Drexler,et al.  Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. , 1991, Circulation.

[37]  G. Berkenboom,et al.  α-Adrenergic Coronary Constriction in Effort Angina , 1991 .

[38]  J. Ross.  Adrenergic Mechanisms in Myocardial Ischemia , 1991, Steinkopff.

[39]  T. Fischell,et al.  Evidence for altered epicardial coronary artery autoregulation as a cause of distal coronary vasoconstriction after successful percutaneous transluminal coronary angioplasty. , 1990, The Journal of clinical investigation.

[40]  G. Heusch.  α‐Adrenergic Mechanisms in Myocardial Ischemia , 1990, Circulation.

[41]  M. Cohen,et al.  Effects of regional alpha- and beta-blockade on resting and hyperemic coronary blood flow in conscious, unstressed humans. , 1989, Circulation.

[42]  M. Marcus,et al.  Heterogeneous Microvascular Coronary α‐Adrenergic Vasoconstriction , 1989 .

[43]  R. Cohen,et al.  Inhibition of Adrenergic Vasoconstriction by Endothelial Cell Shear Stress , 1988, Circulation research.

[44]  M. Marcus,et al.  Small vessel phenomena in the coronary microcirculation: phasic intramyocardial perfusion and coronary microvascular dynamics. , 1988, Progress in cardiovascular diseases.

[45]  J. Stoker,et al.  Changes in myocardial ischaemia during isosorbide dinitrate or indoramin therapy in patients with stable angina using relations between the ST segment and heart rate. , 1988, International journal of cardiology.

[46]  J. Ross,et al.  Intracoronary α2‐Adrenergic Receptor Blockade Attenuates Ischemia in Conscious Dogs During Exercise , 1988, Circulation research.

[47]  E. Nabel,et al.  Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. , 1988, Circulation.

[48]  J. Ross,et al.  Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine. , 1987, Circulation.

[49]  O. Hess,et al.  Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin. , 1986, Circulation.

[50]  M. Winniford,et al.  Smoking-induced coronary vasoconstriction in patients with atherosclerotic coronary artery disease: evidence for adrenergically mediated alterations in coronary artery tone. , 1986, Circulation.

[51]  G. Berkenboom,et al.  Role of alpha-adrenergic coronary tone in exercise-induced angina pectoris. , 1986, The American journal of cardiology.

[52]  M. Marcus,et al.  Adrenergic Coronary Tone during Submaximal Exercise in the Dog is Produced by Circulating Catecholamines: Evidence for Adrenergic Denervation Supersensitivity in the Myocardium but Not in Coronary Vessels , 1986, Circulation research.

[53]  G. Heusch,et al.  Cardiac sympathetic nerve activity and progressive vasoconstriction distal to coronary stenoses: feed-back aggravation of myocardial ischemia. , 1985, Journal of the autonomic nervous system.

[54]  P. Collins,et al.  Improvement in angina pectoris with alpha adrenoceptor blockade. , 1985, British heart journal.

[55]  M. Kern,et al.  Attenuation of coronary vascular resistance by selective alpha 1-adrenergic blockade in patients with coronary artery disease. , 1985, Journal of the American College of Cardiology.

[56]  E L Bolson,et al.  Dynamic mechanisms in human coronary stenosis. , 1984, Circulation.

[57]  E. Bolson,et al.  Reflex constriction of significant coronary stenosis as a mechanism contributing to ischemic left ventricular dysfunction during isometric exercise. , 1984, Circulation.

[58]  G. Heusch,et al.  Alpha 1- and alpha 2-adrenoceptor-mediated vasoconstriction of large and small canine coronary arteries in vivo. , 1984, Journal of cardiovascular pharmacology.

[59]  D. Robertson,et al.  Alpha-adrenergic blockade in vasotonic angina: lack of efficacy of specific alpha 1-receptor blockade with prazosin. , 1983, Journal of the American College of Cardiology.

[60]  G. Heusch,et al.  The Effects of Cardiac Sympathetic Nerve Stimulation on Perfusion of Stenotic Coronary Arteries in the Dog , 1983, Circulation research.

[61]  M. Winniford,et al.  Alpha–adrenergic Blockade for Variant Angina: A Long–term, Double–blind, Randomized Trial , 1983, Circulation.

[62]  G. Vlahakes,et al.  Adrenergic Influence in the Coronary Circulation of Conscious Dogs during Maximal Vasodilation with Adenosine , 1982, Circulation research.

[63]  P. Lichtlen,et al.  [The concept of "dynamic" coronary artery stenosis]. , 1982, Zeitschrift fur Kardiologie.

[64]  W. Chilian,et al.  Evidence against Significant Resting Sympathetic Coronary Vasoconstrictor Tone in the Conscious Dog , 1981, Circulation research.

[65]  J. Muller,et al.  Prevention by Nifedipine of Abnormal Coronary Vasoconstriction in Patients with Coronary Artery Disease , 1981, Circulation.

[66]  E. Verrier,et al.  Cholesterol Potentiates the Coronary Artery Response to Norepinephrine in Anesthetized and Conscious Dogs , 1981, Circulation research.

[67]  G. Mudge,et al.  Comparison of Metabolic and Vasoconstrictor Stimuli on Coronary Vascular Resistance in Man , 1979, Circulation.

[68]  R. M. Mills,et al.  Reflex increase in coronary vascular resistance in patients with ischemic heart disease. , 1976, The New England journal of medicine.

[69]  L. Gould,et al.  Oral phentolamine in angina pectoris. , 1973, Japanese heart journal.

[70]  A Malliani,et al.  A sympathetic reflex elicited by experimental coronary occlusion. , 1969, The American journal of physiology.