Fatal Case of Brucellosis Misdiagnosed in Early Stages of Brucella suis Infection in a 46-Year-Old Patient with Marfan Syndrome

ABSTRACT We report a fatal case of Brucella suis endocarditis initially misdiagnosed by automated identification systems as Ochrobactrum anthropi infection in a patient with a history of Marfan syndrome and recreational feral swine hunting. This report emphasizes the need to consider brucellosis as a part of the differential diagnosis of acute febrile illness, particularly in patients with known risk of exposure.

[1]  C. Saegerman,et al.  Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. , 2011, Preventive veterinary medicine.

[2]  N. Ketheesan,et al.  Brucellosis in northern Australia. , 2010, The American journal of tropical medicine and hygiene.

[3]  J. Setubal,et al.  Characterization of Novel Brucella Strains Originating from Wild Native Rodent Species in North Queensland, Australia , 2010, Applied and Environmental Microbiology.

[4]  D. Lindsay,et al.  Wild boars as sources for infectious diseases in livestock and humans , 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

[5]  Anna R Martirosyan,et al.  The Differential Interaction of Brucella and Ochrobactrum with Innate Immunity Reveals Traits Related to the Evolution of Stealthy Pathogens , 2009, PloS one.

[6]  D. Giurgiutiu,et al.  Brucella suis infection associated with feral swine hunting - three states, 2007-2008. , 2009, MMWR. Morbidity and mortality weekly report.

[7]  Laboratory-acquired brucellosis--Indiana and Minnesota, 2006. , 2008, MMWR. Morbidity and mortality weekly report.

[8]  M. Palmer,et al.  Diagnostic Characterization of a Feral Swine Herd Enzootically Infected with Brucella , 2007, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[9]  J. Barnwell,et al.  Fatal malaria infection in travelers: novel immunohistochemical assays for the detection of Plasmodium falciparum in tissues and implications for pathogenesis. , 2007, The American journal of tropical medicine and hygiene.

[10]  Georgios Pappas,et al.  The new global map of human brucellosis. , 2006, The Lancet. Infectious diseases.

[11]  E. Baron,et al.  Francisella and Brucella. , 2006 .

[12]  E. Jumas‐Bilak,et al.  Molecular and phenotypic features for identification of the opportunistic pathogens Ochrobactrum spp. , 2005, Journal of medical microbiology.

[13]  Bruno Garin-Bastuji,et al.  From the discovery of the Malta fever's agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis. , 2005, Veterinary research.

[14]  E. Bernasconi,et al.  Brucellosis: An occupational hazard for medical laboratory personnel. Report of five cases , 2005, Infection.

[15]  E. James,et al.  Misidentification of Brucella melitensis as Ochrobactrum anthropi by API 20NE. , 2003, Journal of medical microbiology.

[16]  B. Garin‐Bastuji,et al.  Wild boars (Sus scrofa) as reservoirs of Brucella suis biovar 2 in Croatia. , 2003, Acta veterinaria Hungarica.

[17]  K. Nielsen.  Diagnosis of brucellosis by serology. , 2002, Veterinary microbiology.

[18]  E. Moreno,et al.  Brucella evolution and taxonomy. , 2002, Veterinary microbiology.

[19]  P. Rappelli,et al.  Brucella abortus Infection Acquired in Microbiology Laboratories , 2000, Journal of Clinical Microbiology.

[20]  B. Dufour,et al.  False positive serological reactions in bovine brucellosis: evidence of the role of Yersinia enterocolitica serotype O:9 in a field trial. , 1997, Veterinary research.

[21]  M. Corbel.  Recent advances in brucellosis. , 1997, Journal of medical microbiology.

[22]  E. J. Young,et al.  Brucellosis: Clinical and Laboratory Aspects , 1989 .

[23]  L. Hovelius,et al.  Report of Five Cases , 1977 .