Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
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Scar | Teven | S. Goodman | J. Herman | S. Baylin | M. Esteller | Icente | J. García-Foncillas | tephen | Árcia | M Esteller | S B Baylin | J G Herman | E. Andion | O. F. Hidalgo | V. Vanaclocha | Oodman | S N Goodman | J Garcia-Foncillas | E Andion | O F Hidalgo | V Vanaclocha | Aylin | G. N. | Sther | B. B. | Ésűs | S. Goodman | Erman | H. F | H. G. | F. - | Oncillas | Ndion | Idalgo | Anaclocha | Ames | F | Steven N. Goodman | H. G. | James G. Herman | Jesús García-Foncillas | Oscar F. Hidalgo | V. Vanaclocha
[1] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. , 2000, Cancer research.
[2] J. Herman,et al. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. , 2000, Trends in genetics : TIG.
[3] M. Berger,et al. O6-methylguanine-DNA methyltransferase-deficient phenotype in human gliomas: frequency and time to tumor progression after alkylating agent-based chemotherapy. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[4] J. Herman,et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. , 1999, Cancer research.
[5] T. Brent,et al. Methylation of selected CpGs in the human O6‐methylguanine‐DNA methyltransferase promoter region as a marker of gene silencing , 1999, Molecular carcinogenesis.
[6] M. Berger,et al. O 6-Methylguanine-DNA Methyltransferase-deficient Phenotype in Human Gliomas : Frequency and Time to Tumor Progression after Alkylating Agent-based Chemotherapy 1 , 1999 .
[7] M M Haglund,et al. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] H. Eyre,et al. Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] M. Berger,et al. O6-methylguanine-DNA methyltransferase activity in adult gliomas: relation to patient and tumor characteristics. , 1998, Cancer research.
[10] T. Brent,et al. Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. , 1997, Cancer research.
[11] J. Costello,et al. Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene , 1997, Molecular and cellular biology.
[12] M. Dolan,et al. O6-benzylguanine and its role in chemotherapy. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[13] J. Herman,et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[14] M. Prados,et al. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. , 1996, Cancer research.
[15] M. Dolan,et al. Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. , 1995, Progress in nucleic acid research and molecular biology.
[16] M. Berger,et al. Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain. , 1993, Cancer research.
[17] D. Ludlum. DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. , 1990, Mutation research.
[18] M. Dolan,et al. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[19] J. Hilton,et al. Pharmacology of cyclophosphamide and metabolites. , 1981, Cancer treatment reports.