The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia‐inducible factor (HIF)‐2α but not HIF‐1α

Regulatory T cells (TR) mediate peripheral immunological tolerance and are implicated in tumor progression. Because prostate cancer is being investigated for treatment by immunotherapy, we have assessed tumor TR in prostate cancers.

[1]  Stephen B Fox,et al.  Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  A. Vandenbark,et al.  Estrogen‐mediated immunomodulation involves reduced activation of effector T cells, potentiation of treg cells, and enhanced expression of the PD‐1 costimulatory pathway , 2006, Journal of neuroscience research.

[3]  R. Laing,et al.  The COX-2 inhibitor celecoxib and its use in the management of prostate cancer. , 2006 .

[4]  W. Zou.  Regulatory T cells, tumour immunity and immunotherapy , 2006, Nature Reviews Immunology.

[5]  M. Smyth,et al.  CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer1 , 2006, The Journal of Immunology.

[6]  H. Fiegl,et al.  The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer , 2005, Clinical Cancer Research.

[7]  S. Fox,et al.  The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer , 2005, Clinical Cancer Research.

[8]  S. Ziegler,et al.  The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. , 2005, The Journal of clinical investigation.

[9]  Michel Sadelain,et al.  Targeted elimination of prostate cancer by genetically directed human T lymphocytes. , 2005, Cancer research.

[10]  M. Sitkovsky,et al.  Regulation of immune cells by local-tissue oxygen tension: HIF1α and adenosine receptors , 2005, Nature Reviews Immunology.

[11]  Li Zhu,et al.  Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells1 , 2005, The Journal of Immunology.

[12]  for the Statistics Subcommittee of the NCI—EORTC Worki Diagnostics.  REporting recommendations for tumor MARKer prognostic studies (REMARK) , 2005, Nature Clinical Practice Oncology.

[13]  Ashley M. Miller,et al.  Immune Monitoring in a Phase 1 Trial of a PSA DNA Vaccine in Patients with Hormone-Refractory Prostate Cancer , 2005, Journal of immunotherapy.

[14]  W. Jelkmann,et al.  Review: hypoxia-inducible factor-1 (HIF-1): a novel transcription factor in immune reactions. , 2005, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[15]  Hiroshi Nakamura,et al.  TCR Engagement Increases Hypoxia-Inducible Factor-1α Protein Synthesis via Rapamycin-Sensitive Pathway under Hypoxic Conditions in Human Peripheral T Cells1 , 2005, The Journal of Immunology.

[16]  Fiona Powrie,et al.  Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell level , 2005, European journal of immunology.

[17]  M. Manns,et al.  Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. , 2005, Cancer research.

[18]  L. Emens,et al.  Breast cancer vaccines: maximizing cancer treatment by tapping into host immunity. , 2005, Endocrine-related cancer.

[19]  George Coukos,et al.  Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival , 2004, Nature Medicine.

[20]  S. Ziegler,et al.  Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment1 , 2004, The Journal of Immunology.

[21]  F. Powrie,et al.  Regulatory T cells. , 2004, Current opinion in pharmacology.

[22]  P. Kourilsky,et al.  Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells1 , 2004, The Journal of Immunology.

[23]  S. Ziegler,et al.  Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. , 2003, The Journal of clinical investigation.

[24]  H. Fujii,et al.  Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  M. Sitkovsky,et al.  HIF-1α Deficiency Perturbs T and B Cell Functions , 2003 .

[26]  G. Kramer,et al.  Cytokine Expression Pattern in Benign Prostatic Hyperplasia Infiltrating T Cells and Impact of Lymphocytic Infiltration on Cytokine mRNA Profile in Prostatic Tissue , 2003, Laboratory Investigation.

[27]  F. Ramsdell,et al.  An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.

[28]  A. Rudensky,et al.  Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.

[29]  M. Steurer,et al.  Increase of regulatory T cells in the peripheral blood of cancer patients. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[30]  A. Levine,et al.  Prostaglandin E2 Induces Hypoxia-inducible Factor-1α Stabilization and Nuclear Localization in a Human Prostate Cancer Cell Line* , 2002, The Journal of Biological Chemistry.

[31]  T. Eberlein,et al.  Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma1 , 2002, The Journal of Immunology.

[32]  N. Restifo,et al.  Do CD4+ CD25+ immunoregulatory T cells hinder tumor immunotherapy? , 2002, Journal of immunotherapy.

[33]  E. Shevach,et al.  Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells , 2001, The Journal of Immunology.

[34]  A. Enk,et al.  Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood , 2001, The Journal of experimental medicine.

[35]  E. Shevach,et al.  CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.

[36]  T. Nomura,et al.  Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. , 2006, Current topics in microbiology and immunology.

[37]  M. Schilham,et al.  Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans. , 2005, Human immunology.

[38]  M. Sitkovsky,et al.  Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. , 2005, Nature reviews. Immunology.

[39]  Ray H. Baughman,et al.  Supporting Online Material , 2003 .

[40]  M. Sitkovsky,et al.  HIF-1 alpha deficiency perturbs T and B cell functions. , 2003, Current pharmaceutical design.

[41]  Adrian L. Harris,et al.  Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.