Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.

[1]  Andrei Kucharavy,et al.  Targeting the Adaptability of Heterogeneous Aneuploids , 2015, Cell.

[2]  Ashley M. Laughney,et al.  Numerical chromosomal instability mediates susceptibility to radiation treatment , 2015, Nature Communications.

[3]  P. Sorger,et al.  Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress , 2014, Proceedings of the National Academy of Sciences.

[4]  J. Murnane,et al.  DNA-damage response during mitosis induces whole-chromosome missegregation. , 2014, Cancer discovery.

[5]  N. Navin,et al.  Clonal Evolution in Breast Cancer Revealed by Single Nucleus Genome Sequencing , 2014, Nature.

[6]  S. Bakhoum,et al.  Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy , 2014, Cancer.

[7]  William T. Silkworth,et al.  The mitotic origin of chromosomal instability , 2014, Current Biology.

[8]  Zoltan Szallasi,et al.  Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. , 2014, Cancer discovery.

[9]  S. Elledge,et al.  Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome , 2013, Cell.

[10]  Lauren M. Zasadil,et al.  Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors , 2013, Proceedings of the National Academy of Sciences.

[11]  D. Gisselsson,et al.  Elevated Tolerance to Aneuploidy in Cancer Cells: Estimating the Fitness Effects of Chromosome Number Alterations by In Silico Modelling of Somatic Genome Evolution , 2013, PloS one.

[12]  Jiri Bartek,et al.  Replication stress links structural and numerical cancer chromosomal instability , 2013, Nature.

[13]  G. Parmigiani,et al.  Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation , 2013, Proceedings of the National Academy of Sciences.

[14]  Peter J. Campbell,et al.  Evolution of the cancer genome , 2012, Nature Reviews Genetics.

[15]  M. Mann,et al.  Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells , 2012, Molecular Systems Biology.

[16]  Lauren M. Zasadil,et al.  Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons , 2012, Proceedings of the National Academy of Sciences.

[17]  A. McKenna,et al.  Absolute quantification of somatic DNA alterations in human cancer , 2012, Nature Biotechnology.

[18]  D. Compton,et al.  Chromosomal instability and cancer: a complex relationship with therapeutic potential. , 2012, The Journal of clinical investigation.

[19]  P. A. Futreal,et al.  Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. , 2012, The New England journal of medicine.

[20]  Neil J Ganem,et al.  DNA breaks and chromosome pulverization from errors in mitosis , 2012, Nature.

[21]  Rong Li,et al.  Hsp90 Stress Potentiates Rapid Cellular Adaptation through Induction of Aneuploidy , 2012, Nature.

[22]  Prabhjot Kaur,et al.  Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma , 2011, Clinical Cancer Research.

[23]  Nicolai J. Birkbak,et al.  Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[24]  Zoltan Szallasi,et al.  Paradoxical relationship between chromosomal instability and survival outcome in cancer. , 2011, Cancer research.

[25]  Nicolai J. Birkbak,et al.  Chromosomal instability confers intrinsic multidrug resistance. , 2011, Cancer research.

[26]  A. Amon,et al.  Identification of Aneuploidy-Selective Antiproliferation Compounds , 2011, Cell.

[27]  N. Carter,et al.  Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[28]  N. Pavelka,et al.  Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. , 2010, Current opinion in cell biology.

[29]  Anita Saraf,et al.  Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast , 2010, Nature.

[30]  H. Ohtsuki,et al.  Accumulation of driver and passenger mutations during tumor progression , 2009, Proceedings of the National Academy of Sciences.

[31]  D. Compton,et al.  Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability , 2009, Current Biology.

[32]  R. Medema,et al.  Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells , 2009, Proceedings of the National Academy of Sciences.

[33]  Samuel F. Bakhoum,et al.  Genome stability is ensured by temporal control of kinetochore-microtubule dynamics , 2008, Nature Cell Biology.

[34]  Duane A. Compton,et al.  Examining the link between chromosomal instability and aneuploidy in human cells , 2008, The Journal of cell biology.

[35]  Z. Szallasi,et al.  A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers , 2006, Nature Genetics.

[36]  E. Korn,et al.  Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells , 2004, Cancer Research.

[37]  P. Pandolfi,et al.  Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders? , 2002, Trends in molecular medicine.

[38]  W. Dooley,et al.  Long-term dynamics of chromosomal instability in cancer: A transition probability model , 2001 .

[39]  Y. Soini,et al.  Histopathological evaluation of apoptosis in cancer. , 1998, The American journal of pathology.

[40]  A. Andrén-sandberg,et al.  Cytogenetic analysis of pancreatic carcinomas: Intratumor heterogeneity and nonrandom pattern of chromosome aberrations , 1998, Genes, chromosomes & cancer.

[41]  K. Kinzler,et al.  Genetic instability in colorectal cancers , 1997, Nature.

[42]  P. Nowell.  The clonal evolution of tumor cell populations. , 1976, Science.

[43]  Cristina Montagna,et al.  Aneuploidy acts both oncogenically and as a tumor suppressor. , 2007, Cancer cell.

[44]  S. Lowe,et al.  Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. , 2007, Cancer cell.