Bioconcentration kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rainbow trout

The uptake and depuration rate constants for [14C]2,3,7,8-tetrachlorodibenzo-p-dioxin (14C-TCDD) in growing rainbow trout were obtained in a laboratory experiment involving a 6-h static water uptake exposure at 107 ng/L (ppt) followed by a 139-d flow-through depuration period. Improved mathematics were developed for estimating uptake and depuration rate constants and an equilibrium bioconcentration constant that accounts for growth dilution of the total chemical body burden. The uptake and depuration rate constants (k1' and k2) for 14C-TCDD in rainbow trout (whole fish) were determined to be 108 ± 3 ml water/g whole fish/d and 0.012 ± 0.001 d−1, respectively. Based on these data, the equilibrium bioconcentration constant for TCDD, defined as the ratio of uptake to depuration rate constants, was 9,270 ± 1,050, and the elimination half-life, t1/2, of the total body burden was 58 ± 5 d. Clinical observations of the fish concurred with those previously reported by other researchers.

[1]  M. Connor.  Fish/sediment concentration ratios for organic compounds. , 1984, Environmental science & technology.

[2]  C. T. Chiou,et al.  Partition coefficient and bioaccumulation of selected organic chemicals , 1977 .

[3]  T. Nestrick,et al.  Determination of part-per-trillion concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin in fish. , 1979, Analytical chemistry.

[4]  R. Miller,et al.  Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in aquatic organisms. , 1973, Environmental health perspectives.

[5]  A. Isensee,et al.  Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in aquatic model ecosystem , 1975 .

[6]  Gary E. Blau,et al.  Partition coefficient to measure bioconcentration potential of organic chemicals in fish , 1974 .

[7]  O. Hutzinger,et al.  Bioaccumulation of super‐lipophilic chemicals in fish , 1984 .

[8]  F. Matsumura,et al.  Fate of 2,3,7,8‐tetrachlorodibenzo‐P‐dioxin (TCDD) in an outdoor pond and in model aquatic ecosystems , 1982 .

[9]  A. L. Jensen,et al.  PCB Uptake by Five Species of Fish in Lake Michigan, Green Bay of Lake Michigan, and Cayuga Lake, New York , 1982 .

[10]  Kees Olie,et al.  Chlorodibenzo-p-dioxins and chlorodibenzofurans are trace components of fly ash and flue gas of some municipal incinerators in The Netherlands , 1977 .

[11]  Gary E. Blau,et al.  Ecokinetics: A study of the fate and distribution of chemicals in laboratory ecosystems , 1975 .

[12]  G. Blau,et al.  Bioconcentration of 2,2′,4,4′-Tetrachlorobiphenyl in Rainbow Trout as Measured by an Accelerated Test , 1975 .

[13]  Sujit Banerjee,et al.  Water solubility and octanol/water partition coefficients of organics. Limitations of the solubility-partition coefficient correlation , 1980 .

[14]  A. Kende,et al.  Synthesis of new steric and electronic analogs of 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1973, Environmental health perspectives.

[15]  S. Petrocelli,et al.  Considerations in Assessing the Potential for, and Significance of, Biomagnification of Chemical Residues in Aquatic Food Chains , 1979 .