FlyBase: enhancing Drosophila Gene Ontology annotations

FlyBase (http://flybase.org) is a database of Drosophila genetic and genomic information. Gene Ontology (GO) terms are used to describe three attributes of wild-type gene products: their molecular function, the biological processes in which they play a role, and their subcellular location. This article describes recent changes to the FlyBase GO annotation strategy that are improving the quality of the GO annotation data. Many of these changes stem from our participation in the GO Reference Genome Annotation Project--a multi-database collaboration producing comprehensive GO annotation sets for 12 diverse species.

[1]  Michel Schneider,et al.  UniProtKB/Swiss-Prot. , 2007, Methods in molecular biology.

[2]  Madeline A. Crosby,et al.  FlyBase: genomes by the dozen , 2006, Nucleic Acids Res..

[3]  Joshua L. Goodman,et al.  FlyBase: integration and improvements to query tools , 2007, Nucleic Acids Res..

[4]  Melanie A. Huntley,et al.  Evolution of genes and genomes on the Drosophila phylogeny , 2007, Nature.

[5]  Emily Dimmer,et al.  An evaluation of GO annotation retrieval for BioCreAtIvE and GOA , 2005, BMC Bioinformatics.

[6]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[7]  Giorgio Valle,et al.  The Gene Ontology project in 2008 , 2007, Nucleic Acids Res..

[8]  Robert D. Finn,et al.  New developments in the InterPro database , 2007, Nucleic Acids Res..