Formulation and Characterization of Etoricoxib Olive Oil Emulgel by Using Different Gelling Agents

In present time emulgel is new plateform for drug delievery system because it is useful for hydrophobic drugs. Currently emulsified gels have been growing faster in pharmaceutical topical dosage forms as well as another topical semisolid dosage form. Etoricoxib , a non-steroidal anti-inflammatory drug, has been used in the treatment of joint pain, inflammation, arthritis. Etoricoxib reduces pain and inflammation by blocking COX2, enzyme in the body. This study was conducted to comparison study of parameters of marketed etoricoxib emulgel formulation. The purpose of this study is to evaluate the safety and effectiveness of a new experimental medication for the treatment of moderate to severe joint pain and inflammation. For fulfilling this approach, we are preparting emulgel from Etoricoxib and oil phase of olive oil in emulsion. Because the delivery of the hydrophobic drugs are not possible by simple hydro gel that is only possible by formulating emulgel (emulsion + gel). On the other hand oil phase of olive oil contain oleocanthal, which prevents the production of pro-inflammatory COX-1 and COX-2 similar to classical nonsteroidal anti-inflammatory drugs, which is same as etoricoxib, a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with anti inflammatory activity. To prepared formulation was to undergone various preliminary evaluation like Appearance, pH of gel, drug content, rheological study, spread ability, Extudability. To this study was to concluding that out of six formulation F2 formulation showed the effective result of % drug release and the emulgel of etoricoxib was successfully formulate and evaluate found to be compatible topically.