Sleep in Parkinson’s Disease

Two major sources of dissatisfaction with the quality of life among Parkinsonian patients are the “locomotor disability” and the “nature of their sleep”. The main focus of research was directed towards the locomotor disability, but in the last two decades some progress has been made towards the understanding of sleep in PD patients. Sleep in Parkinson's disease is light and fragmented due to an increased skeletal muscle activity, disturbed breathing, impaired biological rhythm and REM‐nonREM variations of the dopaminergic receptor sensitivity.

[1]  C. Tanner,et al.  Development and progression of motor fluctuations and side effects in Parkinson's disease: comparison of Sinemet CR versus carbidopa/levodopa. , 1989, Neurology.

[2]  W C Dement,et al.  Sleep apnoea syndrome: states of sleep and autonomic dysfunction. , 1977, Journal of neurology, neurosurgery, and psychiatry.

[3]  T. Perry,et al.  Dominantly inherited apathy, central hypoventilation, and Parkinson's syndrome , 1990, Neurology.

[4]  J. Askenasy,et al.  Reversal of sleep disturbance in Parkinson's disease by antiparkinsonian therapy , 1985, Neurology.

[5]  W. Weiner,et al.  Sleep disorders and sleep effect in Parkinson's disease , 1990, Movement disorders : official journal of the Movement Disorder Society.

[6]  W. Gowers,et al.  A Manual of Diseases of the Nervous System , 1887, Edinburgh Medical Journal.

[7]  M. Mark,et al.  Controlled-release carbidopa-levodopa (Sinemet) in combination with standard Sinemet in advanced Parkinson's disease. , 1989, Annals of clinical and laboratory science.

[8]  P. James.  An Essay on the Shaking Palsy , 1817, The Medico-Chirurgical Journal and Review.

[9]  N. A. Blackburn,et al.  The nighttime problems of Parkinson's disease. , 1988, Clinical neuropharmacology.

[10]  Y. Furukawa,et al.  [Hereditary progressive dystonia with marked diurnal fluctuation (HPD)]. , 1993, Nihon rinsho. Japanese journal of clinical medicine.

[11]  R. Penn,et al.  Adrenal medullary transplant to the striatum of patients with advanced Parkinson's disease , 1990, Neurology.

[12]  J. Friedman,et al.  Respiration and sleep in Parkinson's disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[13]  The treatment of sleep disorders of older people. , 1990, Consensus statement. National Institutes of Health Consensus Development Conference.

[14]  J. Askenasy.  Sleep patterns in extrapyramidal disorders. , 1981, International journal of neurology.

[15]  H. Moldofsky,et al.  Abnormal respiratory pattern generation during sleep in patients with autonomic dysfunction. , 1983, The American review of respiratory disease.

[16]  R. Pfeiffer,et al.  Clozapine for psychosis in Parkinson's disease , 1990, Movement disorders : official journal of the Movement Disorder Society.

[17]  F. Goodwin,et al.  REM inhibitory effect of L-DOPA infusion during human sleep. , 1973, Electroencephalography and clinical neurophysiology.

[18]  J. Askenasy,et al.  Isolated Phasic Discharges in Anterior Tibial Muscle: A Stable Feature of Paradoxical Sleep , 1988, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[19]  P. Bertolucci,et al.  Rem sleep deprivation in an experimental model of Parkinson's disease. , 1987, Arquivos de neuro-psiquiatria.

[20]  J. Askenasy,et al.  Sleep tonus inversion: a feature of juvenile dystonic parkinsonism , 1989, Acta neurologica Scandinavica.

[21]  J. Horiguchi,et al.  [Sleep-wake complaints in Parkinson's disease]. , 1990, Rinsho shinkeigaku = Clinical neurology.

[22]  S. Locke.  Clinical Neurology , 1953, Progress in neurology and psychiatry.

[23]  M. Jouvet,et al.  Biogenic amines and the states of sleep. , 1969, Science.

[24]  J. Askenasy,et al.  Parkinsonian tremor loses its alternating aspect during non-REM sleep and is inhibited by REM sleep. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[25]  D. Murphy,et al.  Deprenyl in Parkinson disease , 1981, Neurology.

[26]  A. Laihinen,et al.  Sleep movements and associated autonomic nervous activities in patients with Parkinson's disease , 1987, Acta neurologica Scandinavica.

[27]  C. Kennard,et al.  Respiration and sleep in Parkinson's disease. , 1985, Journal of neurology, neurosurgery, and psychiatry.

[28]  N. Kleitman,et al.  Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. , 1953, Science.

[29]  C. Markham,et al.  Sleep in patients with Parkinson's disease and normal subiects prior to and following levodopa administration , 1971, Clinical pharmacology and therapeutics.

[30]  National Institutes of Health Consensus Development Conference Statement: the treatment of sleep disorders of older people March 26-28, 1990. , 1991, Sleep.

[31]  A. Lees,et al.  Subcutaneous apomorphine in the treatment of Parkinson's disease. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[32]  R. Hardie,et al.  Respiration and sleep in Parkinson's disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[33]  J. Dambrosia,et al.  Lisuride in parkinsonism , 1981, Neurology.

[34]  P. Bertolucci,et al.  Total sleep deprivation and Parkinson disease. , 1987, Arquivos de neuro-psiquiatria.