Coagulation system in toxemia of pregnancy.

We studied hematological changes in toxemia of pregnancy and obtained the following conclusion. Toxemia of pregnancy is accompanied by a significant extension in bleeding time, a decrease in levels of fibrinogen and plasma factor XIII, significant increases in prothrombin time and active partial thromboplastin time, and significant increases in serum-urine FDP, platelet aggregation and platelet spreadability as compared to normal gravidas. Toxemia of pregnancy assumed an aspect of chronic DIC.

[1]  J. Pritchard,et al.  Coagulation changes in eclampsia: their frequency and pathogenesis. , 1976, American journal of obstetrics and gynecology.

[2]  E. Page.  ON THE PATHOGENESIS OF PRE‐ECLAMPSIA AND ECLAMPSIA * , 1972, The Journal of obstetrics and gynaecology of the British Commonwealth.

[3]  A. S. Douglas,et al.  Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia , 1971, British medical journal.

[4]  D. Woodfield,et al.  Serum Fibrin Degradation Products Throughout Normal Pregnancy , 1968, British medical journal.

[5]  A. Sedlis,et al.  PLATELET ADHESIVENESS IN TOXEMIA OF PREGNANCY. , 1964, American journal of obstetrics and gynecology.

[6]  C. Schneider,et al.  Experimental pulmonary arterial occlusions; acute cor pulmonale simulating obstetrical shock of late pregnancy. , 1954, American journal of obstetrics and gynecology.

[7]  W. J. Dieckmann.  Blood chemistry and renal function in abruptio placentae , 1936 .