Global burden of COPD

It is estimated that the world population will reach a record 7.3 billion in 2015, and the high burden of chronic conditions associated with ageing and smoking will increase further. Respiratory diseases in general receive little attention and funding in comparison with other major causes of global morbidity and mortality. In particular, chronic obstructive pulmonary disease (COPD) has been a major public health problem and will remain a challenge for clinicians within the 21st century. Worldwide, COPD is in the spotlight, since its high prevalence, morbidity and mortality create formidable challenges for health‐care systems. This review emphasizes the magnitude of the COPD problem from a clinician's standpoint by drawing extensively from the new findings of the Global Burden of Disease study. Updated, distilled information on the population distribution of COPD is useful for the clinician to help provide an appreciation of the relative impact of COPD in daily practice compared with other chronic conditions, and to allocate minimum resources in anticipation of future needs in care. Despite recent trends in reduction of COPD standardized mortality rates and some recent successes in anti‐smoking efforts in a number of Western countries, the overarching demographic impact of ageing in an ever‐expanding world population, joined with other factors such as high rates of smoking and air pollution in Asia, will ensure that COPD will continue to pose an ever‐increasing problem well into the 21st century.

[1]  P. Palange,et al.  Harmonising spirometry education with HERMES: training a new generation of qualified spirometry practitioners across Europe , 2011, European Respiratory Journal.

[2]  R. Golpe,et al.  Are the Diagnostic Criteria for Asthma-COPD Overlap Syndrome Appropriate in Biomass Smoke-Induced chronic obstructive pulmonary disease? , 2016, Archivos de bronconeumologia.

[3]  M. White,et al.  Prevalence of heavy smoking in California and the United States, 1965-2007. , 2011, JAMA.

[4]  E. Hnizdo,et al.  Changes in prevalence of chronic obstructive pulmonary disease and asthma in the US population and associated risk factors , 2015, Chronic respiratory disease.

[5]  Majid Ezzati,et al.  Global Burden of Disease 2005: call for collaborators , 2007, The Lancet.

[6]  Bernadette A. Thomas,et al.  Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 , 2015, The Lancet.

[7]  P. Paré,et al.  COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women , 2013, European Respiratory Journal.

[8]  Anastasia E. Raczek,et al.  Development and Initial Validation of a Self-Scored COPD Population Screener Questionnaire (COPD-PS) , 2008, COPD.

[9]  N. Zhong,et al.  Lung Function and Incidence of Chronic Obstructive Pulmonary Disease after Improved Cooking Fuels and Kitchen Ventilation: A 9-Year Prospective Cohort Study , 2014, PLoS medicine.

[10]  M. V. Lopez Varela,et al.  ALAT-2014 Chronic Obstructive Pulmonary Disease (COPD) Clinical Practice Guidelines: questions and answers. , 2015, Archivos de bronconeumologia.

[11]  Edwin K Silverman,et al.  An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. , 2010, American journal of respiratory and critical care medicine.

[12]  A. Crockett,et al.  COPD Diagnostic Questionnaire (CDQ) for selecting at-risk patients for spirometry: a cross-sectional study in Australian general practice , 2014, npj Primary Care Respiratory Medicine.

[13]  R. Minamisava,et al.  Knowledge about COPD among users of primary health care services , 2014, International journal of chronic obstructive pulmonary disease.

[14]  X. Baur,et al.  Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach , 2012, Journal of Occupational Medicine and Toxicology.

[15]  A. Fernández-Villar,et al.  Short- and long-term effectiveness of a supervised training program in spirometry use for primary care professionals. , 2013, Archivos de bronconeumologia.

[16]  N. Chavannes,et al.  Prevalence of chronic obstructive pulmonary disease and associated risk factors in Uganda (FRESH AIR Uganda): a prospective cross-sectional observational study. , 2015, The Lancet. Global health.

[17]  K. Bang,et al.  Chronic Obstructive Pulmonary Disease Prevalence Among Nonsmokers by Occupation in the United States , 2013, Journal of occupational and environmental medicine.

[18]  Stephen S. Lim,et al.  Cost effectiveness of strategies to combat cardiovascular disease, diabetes, and tobacco use in sub-Saharan Africa and South East Asia: mathematical modelling study , 2012, BMJ : British Medical Journal.

[19]  A. Buist,et al.  Case-finding options for COPD: results from the Burden of Obstructive Lung Disease Study , 2012, European Respiratory Journal.

[20]  C. Roberts,et al.  Variability of hospital resources for acute care of COPD patients: the European COPD Audit , 2013, European Respiratory Journal.

[21]  M. Miravitlles,et al.  Conocimientos de la población general sobre la enfermedad pulmonar obstructiva crónica y sus determinantes: situación actual y cambios recientes , 2012 .

[22]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[23]  Bernadette A. Thomas,et al.  Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[24]  S. Jang,et al.  Awareness of chronic obstructive pulmonary disease in current smokers: a nationwide survey , 2015, The Korean journal of internal medicine.

[25]  D. Mannino,et al.  Continuing to Confront COPD International Surveys: comparison of patient and physician perceptions about COPD risk and management , 2015, International journal of chronic obstructive pulmonary disease.

[26]  D. Price,et al.  Detection of airflow limitation using a handheld spirometer in a primary care setting , 2014, Respirology.

[27]  C. Represas-Represas,et al.  Short- and long-term effectiveness of a supervised training program in spirometry use for primary care professionals. , 2013, Archivos de bronconeumologia.

[28]  Anand A. Dalal,et al.  A clinical study of COPD severity assessment by primary care physicians and their patients compared with spirometry. , 2015, The American journal of medicine.

[29]  D. Chisholm,et al.  Cost effectiveness of strategies to combat chronic obstructive pulmonary disease and asthma in sub-Saharan Africa and South East Asia: mathematical modelling study , 2012, British medical journal.

[30]  Y. S. Kim,et al.  Health care use and economic burden of patients with diagnosed chronic obstructive pulmonary disease in Korea. , 2014, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[31]  A. Sicras-Mainar,et al.  The Effect of Quitting Smoking on Costs and Healthcare Utilization in Patients with Chronic Obstructive Pulmonary Disease: A Comparison of Current Smokers Versus Ex-Smokers in Routine Clinical Practice , 2014, Lung.

[32]  E. Wouters Economic analysis of the Confronting COPD survey: an overview of results. , 2003, Respiratory medicine.

[33]  M. Twigg,et al.  Chronic obstructive pulmonary disease case finding by community pharmacists: a potential cost‐effective public health intervention , 2015, The International journal of pharmacy practice.

[34]  D. Mannino,et al.  Continuing to Confront COPD International Physician Survey: physician knowledge and application of COPD management guidelines in 12 countries , 2014, International journal of chronic obstructive pulmonary disease.

[35]  G. Wesseling,et al.  External validation of a COPD diagnostic questionnaire , 2008, European Respiratory Journal.

[36]  P. Śliwiński,et al.  Chronic obstructive pulmonary disease in the awareness of Polish society. Report from the public opinion survey by the Polish Respiratory Society and TNS Polska. , 2015, Pneumonologia i alergologia polska.

[37]  J. Soriano,et al.  Recent trends in COPD prevalence in Spain: a repeated cross-sectional survey , 2009, ATS 2009.

[38]  M. V. Lopez Varela,et al.  ALAT-2014 Chronic Obstructive Pulmonary Disease (COPD) Clinical Practice Guidelines: questions and answers. , 2015, Archivos de bronconeumologia.

[39]  Dirkje S Postma,et al.  Risk factors and early origins of chronic obstructive pulmonary disease , 2015, The Lancet.

[40]  M. Miravitlles,et al.  Infradiagnóstico de la enfermedad pulmonar obstructiva crónica en mujeres: cuantificación del problema, determinantes y propuestas de acción , 2013 .

[41]  R. Kozu,et al.  Effect of a chronic obstructive pulmonary disease (COPD) intervention on COPD awareness in a regional city in Japan. , 2015, Internal medicine.

[42]  B. Clin,et al.  Agricultural exposures and chronic bronchitis: findings from the AGRICAN (AGRIculture and CANcer) cohort. , 2013, Annals of epidemiology.

[43]  D. Mannino,et al.  Economic Burden of COPD in the Presence of Comorbidities , 2015, Chest.

[44]  B. Celli,et al.  Exacerbations of chronic obstructive pulmonary disease , 2007, European Respiratory Journal.

[45]  C. Lenfant,et al.  Global Initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease , 2006 .

[46]  D. Mannino,et al.  Global burden of COPD: risk factors, prevalence, and future trends , 2007, The Lancet.

[47]  D Behera,et al.  Respiratory symptoms in Indian women using domestic cooking fuels. , 1991, Chest.

[48]  J. Soriano,et al.  The general public's knowledge of chronic obstructive pulmonary disease and its determinants: current situation and recent changes. , 2012, Archivos de bronconeumologia.

[49]  ALAT-2014 Chronic Obstructive Pulmonary Disease (COPD) Clinical Practice Guidelines: questions and answers. , 2015 .

[50]  M. Oyarzún,et al.  Pathogenic mechanisms in chronic obstructive pulmonary disease due to biomass smoke exposure. , 2015, Archivos de bronconeumologia.

[51]  Y. Oh,et al.  Patterns and determinants of COPD-related healthcare utilization by severity of airway obstruction in Korea , 2014, BMC Pulmonary Medicine.

[52]  J. Soriano,et al.  Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities , 2009, Thorax.

[53]  C. D. Mathers,et al.  Chronic obstructive pulmonary disease: current burden and future projections , 2006, European Respiratory Journal.

[54]  Bernadette A. Thomas,et al.  Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[55]  Ki Moon Bang,et al.  Association between chronic obstructive pulmonary disease and employment by industry and occupation in the US population: a study of data from the Third National Health and Nutrition Examination Survey. , 2002, American journal of epidemiology.

[56]  John E Connett,et al.  Smoking and lung function of Lung Health Study participants after 11 years. , 2002, American journal of respiratory and critical care medicine.

[57]  J. Zhao,et al.  Vulnerability, beliefs, treatments and economic burden of chronic obstructive pulmonary disease in rural areas in China: a cross-sectional study , 2012, BMC Public Health.

[58]  Joseph Menzin,et al.  Assessment of the Economic Burden of COPD in the U.S.: A Review and Synthesis of the Literature , 2006, COPD.

[59]  D. Mannino,et al.  Economic Burden of Chronic Obstructive Pulmonary Disease by Presence of Comorbidities , 2015 .

[60]  M. Oyarzún,et al.  Pathogenic mechanisms in chronic obstructive pulmonary disease due to biomass smoke exposure. , 2015, Archivos de bronconeumologia.

[61]  A. Buist,et al.  Present and future costs of COPD in Iceland and Norway: results from the BOLD study , 2009, European Respiratory Journal.

[62]  Timothy Tilert,et al.  Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007–2010 , 2013, Respiratory Research.

[63]  D. Mannino,et al.  International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study , 2007, The Lancet.

[64]  S. Yusuf,et al.  The burden of disease in older people and implications for health policy and practice , 2015, The Lancet.

[65]  Karl Claxton,et al.  Unrelated Future Costs and Unrelated Future Benefits: Reflections on NICE Guide to the Methods of Technology Appraisal. , 2016, Health economics.

[66]  Alan D. Lopez,et al.  Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study , 1997, The Lancet.

[67]  J. Soriano,et al.  Recent trends in COPD prevalence in Spain: a repeated cross-sectional survey 1997–2007 , 2009, European Respiratory Journal.

[68]  M. Linehan,et al.  The diagnostic accuracies of chronic obstructive pulmonary disease (COPD) in general practice: The results of the MAGIC (Manchester Airways Group Identifying COPD) study. , 2006, Primary care respiratory journal : journal of the General Practice Airways Group.

[69]  Alan D. Lopez,et al.  Measuring the global burden of disease and epidemiological transitions: 2002–2030 , 2006, Annals of tropical medicine and parasitology.

[70]  J. Soriano,et al.  Underdiagnosis of chronic obstructive pulmonary disease in women: quantification of the problem, determinants and proposed actions. , 2013, Archivos de bronconeumologia.

[71]  Y. Oh,et al.  The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data , 2013, International journal of chronic obstructive pulmonary disease.

[72]  P. Casán,et al.  Airflow obstruction case finding in community-pharmacies: a novel strategy to reduce COPD underdiagnosis. , 2015, Respiratory medicine.

[73]  D. Hilleman,et al.  Economic Burden of Chronic Obstructive Pulmonary Disease , 2012, PharmacoEconomics.

[74]  M. Miravitlles,et al.  Chronic respiratory symptoms, spirometry and knowledge of COPD among general population. , 2006, Respiratory medicine.

[75]  D. Jarvis,et al.  The global burden of chronic respiratory disease in adults. , 2015, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[76]  W. Vollmer,et al.  Marijuana and chronic obstructive lung disease: a population-based study , 2009, Canadian Medical Association Journal.

[77]  Cesar G Victora,et al.  Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study , 2005, The Lancet.

[78]  J. Vestbo,et al.  Potential misclassification of causes of death from COPD , 2006, European Respiratory Journal.

[79]  J. Soriano,et al.  A comprehensive, national survey of spirometry in Spain: current bottlenecks and future directions in primary and secondary care. , 2013, Chest.

[80]  P. Mahesh,et al.  Identification of a threshold for biomass exposure index for chronic bronchitis in rural women of Mysore district, Karnataka, India , 2013, The Indian journal of medical research.

[81]  H. Zar,et al.  Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries. , 2015, The Lancet. Respiratory medicine.

[82]  C. Mathers,et al.  Projections of Global Mortality and Burden of Disease from 2002 to 2030 , 2006, PLoS medicine.

[83]  T. Pless-mulloli,et al.  COPD prevalence and its association with occupational exposures in a general population , 2010, European Respiratory Journal.

[84]  Sarah B Henderson,et al.  Evaluation of interventions to reduce air pollution from biomass smoke on mortality in Launceston, Australia: retrospective analysis of daily mortality, 1994-2007 , 2013, BMJ.

[85]  T. Laatikainen,et al.  Twenty-five year trends in prevalence of chronic bronchitis and the trends in relation to smoking. , 2014, Respiratory medicine.

[86]  J. Soriano,et al.  Chronic obstructive pulmonary disease overview: epidemiology, risk factors, and clinical presentation. , 2011, Proceedings of the American Thoracic Society.

[87]  P. Moayyedi,et al.  Comparison of nebulised salbutamol and ipratropium bromide with salbutamol alone in the treatment of chronic obstructive pulmonary disease. , 1995, Thorax.

[88]  J. Soriano,et al.  Mortality trends in chronic obstructive pulmonary disease in Europe, 1994-2010: a joinpoint regression analysis. , 2014, The Lancet. Respiratory medicine.