Visuospatial perception and navigation in Parkinson’s disease

A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.

[1]  Heinrich H. Bülthoff,et al.  The use of optical flow and splay angle in steering a central path , 1999 .

[2]  I. Brown,et al.  Vision in Vehicles III , 1991 .

[3]  E. Johnsen,et al.  Improved asymmetry of gait in Parkinson's disease with DBS: Gait and postural instability in Parkinson's disease treated with bilateral deep brain stimulation in the subthalamic nucleus , 2009, Movement disorders : official journal of the Movement Disorder Society.

[4]  A. Cronin-Golomb,et al.  Visual and spatial symptoms in Parkinson’s disease , 2005, Vision Research.

[5]  A. Duchon,et al.  A Visual Equalization Strategy for Locomotor Control: Of Honeybees, Robots, and Humans , 2002, Psychological science.

[6]  R. Wagenaar,et al.  Impact of optic flow perception and egocentric coordinates on veering in Parkinson's disease. , 2008, Brain : a journal of neurology.

[7]  Laura Telford,et al.  Role of optical flow field asymmetry in the perception of heading during linear motion , 1996, Perception & psychophysics.

[8]  J. E. Giphart,et al.  Effects of Virtual Reality Immersion and Walking Speed on Coordination of Arm and Leg Movements , 2007, PRESENCE: Teleoperators and Virtual Environments.

[9]  E. Saltzman,et al.  Effects of optic flow speed and lateral flow asymmetry on locomotion in younger and older adults: a virtual reality study. , 2009, The journals of gerontology. Series B, Psychological sciences and social sciences.

[10]  H. Karnath,et al.  Trunk orientation as the determining factor of the 'contralateral' deficit in the neglect syndrome and as the physical anchor of the internal representation of body orientation in space. , 1991, Brain : a journal of neurology.

[11]  Melissa M Amick,et al.  Role of a lateralized parietal-basal ganglia circuit in hierarchical pattern perception: evidence from Parkinson's disease. , 2009, Behavioral neuroscience.

[12]  V. Bruce,et al.  Visual Perception: Physiology, Psychology and Ecology , 1985 .

[13]  W. Berger,et al.  Visual influence on human locomotion Modulation to changes in optic flow , 1997, Experimental Brain Research.

[14]  R. van Emmerik,et al.  Resonant frequencies of arms and legs identify different walking patterns. , 2000, Journal of biomechanics.

[15]  M. Hallett,et al.  Pathophysiology of bradykinesia in Parkinson's disease. , 2001, Brain : a journal of neurology.

[16]  A. W. Blackwell,et al.  Perception of circular heading from optical flow. , 1991, Journal of experimental psychology. Human perception and performance.

[17]  M. S. Fowler,et al.  Hemispace differences in the visual perception of size in left hemiParkinson’s disease , 2003, Neuropsychologia.

[18]  H E Bedell,et al.  The precision of velocity discrimination across spatial frequency , 1998, Perception & psychophysics.

[19]  Anders Löfqvist,et al.  Dynamics of intergestural timing: a perturbation study of lip-larynx coordination , 1998, Experimental Brain Research.

[20]  W. Warren,et al.  Perception of translational heading from optical flow. , 1988, Journal of experimental psychology. Human perception and performance.

[21]  R C Wagenaar,et al.  Effects of walking velocity on relative phase dynamics in the trunk in human walking. , 1996, Journal of biomechanics.

[22]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[23]  W. Berger,et al.  Visual kinesthesia and locomotion in Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[24]  A. Cronin-Golomb,et al.  Parkinson’s Disease as a Disconnection Syndrome , 2010, Neuropsychology Review.

[25]  J. Konczak,et al.  Haptic Perception of Object Curvature in Parkinson's Disease , 2008, PloS one.

[26]  V. Fung,et al.  Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test. , 2003, Archives of neurology.

[27]  D. Cunningham,et al.  Age-related changes in speed of walking. , 1988, Medicine and science in sports and exercise.

[28]  Dagmar Sternad,et al.  Dynamics of 1:2 Coordination: Generalizing Relative Phase to n:m Rhythms. , 1999, Journal of motor behavior.

[29]  Dani Byrd,et al.  Task-dynamics of gestural timing: Phase windows and multifrequency rhythms , 2000 .

[30]  J. Summers,et al.  Stride length regulation in Parkinson's disease. Normalization strategies and underlying mechanisms. , 1996, Brain : a journal of neurology.

[31]  M. S. Fowler,et al.  Evidence from a line bisection task for visuospatial neglect in Left Hemiparkinson's disease , 2001, Vision Research.

[32]  William H. Warren,et al.  Optic flow is used to control human walking , 2001, Nature Neuroscience.

[33]  V. Bruce,et al.  Visual perception: Physiology, psychology and ecology, 2nd ed. , 1990 .

[34]  Alison Lee,et al.  Problems with perception of space in Parkinson’s disease: a questionnaire study , 1999 .

[35]  M. S. Fowler,et al.  Disruption of estimation of body-scaled aperture width in Hemiparkinson's disease , 2001, Neuropsychologia.

[36]  J. Konczak.  Effects of optic flow on the kinematics of human gait: a comparison of young and older adults. , 1994, Journal of motor behavior.

[37]  G. Ganis,et al.  Frontostriatal circuits are necessary for visuomotor transformation: Mental rotation in Parkinson's disease , 2006, Neuropsychologia.

[38]  Brian P. Dyre,et al.  Image velocity magnitudes and perception of heading. , 1997, Journal of experimental psychology. Human perception and performance.

[39]  Jeffrey M. Hausdorff,et al.  The role of gait rhythmicity and bilateral coordination of stepping in the pathophysiology of freezing of gait in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[40]  Xuemei Huang,et al.  Arm swing magnitude and asymmetry during gait in the early stages of Parkinson's disease. , 2010, Gait & posture.

[41]  Marco Schieppati,et al.  Tuning of a basic coordination pattern constructs straight-ahead and curved walking in humans. , 2004, Journal of neurophysiology.

[42]  Richard M Wilkie,et al.  Judgments of path, not heading, guide locomotion. , 2006, Journal of experimental psychology. Human perception and performance.