Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen‐presenting cells in mice

Sublingual immunotherapy (SLIT) has proven to be safe and efficient for the treatment of type I allergies. However, the mechanisms underlying allergen transportation within the sublingual compartment, the localization of antigens, and the identities of the cells responsible for this immunization remain incompletely understood.

[1]  A. Hovav.  Dendritic cells of the oral mucosa , 2013, Mucosal Immunology.

[2]  D. Ladant,et al.  Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice , 2011, Mucosal Immunology.

[3]  M. Clerici,et al.  Immunological Effects of Sublingual Immunotherapy: Clinical Efficacy Is Associated with Modulation of Programmed Cell Death Ligand 1, IL-10, and IgG4 , 2010, The Journal of Immunology.

[4]  H. Kiyono,et al.  Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. , 2010, Nature materials.

[5]  N. Cerf-Bensussan,et al.  Multiple facets of intestinal permeability and epithelial handling of dietary antigens , 2010, Mucosal Immunology.

[6]  J. Schiller,et al.  Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection1 , 2009, The Journal of Immunology.

[7]  T. Bieber,et al.  Dendritic cells as potential targets for mucosal immunotherapy , 2009, Current opinion in allergy and clinical immunology.

[8]  S. Akira,et al.  Id2-, RORγt-, and LTβR-independent initiation of lymphoid organogenesis in ocular immunity , 2009, The Journal of experimental medicine.

[9]  L. Klimek,et al.  Efficacy of grass pollen sublingual immunotherapy for three consecutive seasons and after cessation of treatment: the ECRIT study , 2009, Allergy.

[10]  I. Brook.  The bacteriology of salivary gland infections. , 2009, Oral and maxillofacial surgery clinics of North America.

[11]  C. Czerkinsky,et al.  CCR7-CCL19/CCL21-Regulated Dendritic Cells Are Responsible for Effectiveness of Sublingual Vaccination1 , 2009, The Journal of Immunology.

[12]  Carl-Fredrik Flach,et al.  B Lymphocytes Promote Expansion of Regulatory T Cells in Oral Tolerance: Powerful Induction by Antigen Coupled to Cholera Toxin B Subunit1 , 2008, The Journal of Immunology.

[13]  A. Louise,et al.  Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. , 2008, The Journal of allergy and clinical immunology.

[14]  T. Bieber,et al.  Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? , 2008, Allergy.

[15]  S. Durham,et al.  Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years. , 2008, The Journal of allergy and clinical immunology.

[16]  T. Bieber,et al.  Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. , 2008, The Journal of allergy and clinical immunology.

[17]  B. Pulendran,et al.  Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses , 2007, Nature Immunology.

[18]  E. Valovirta,et al.  Sublingual immunotherapy in children modulates allergen‐induced in vitro expression of cytokine mRNA in PBMC , 2006, Allergy.

[19]  C. Akdis,et al.  Immunological mechanisms of sublingual immunotherapy , 2006, Allergy.

[20]  G. Ciprandi,et al.  Sublingual immunotherapy and regulatory T cells , 2006, Allergy.

[21]  S. Durham,et al.  Sublingual immunotherapy for allergic rhinitis: systematic review and meta‐analysis * , 2005, Allergy.

[22]  S. Burastero,et al.  Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. , 2004, The Journal of allergy and clinical immunology.

[23]  S. Fukuyama,et al.  NALT- versus PEYER'S-patch-mediated mucosal immunity , 2004, Nature Reviews Immunology.

[24]  S. Durham,et al.  Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.