Computer simulation of CT mammography using a flat-panel imager

Software has been developed to simulate a cone-beam CT mammography imaging system that consists of an x-ray tube and a flat-panel detector that rotate simultaneously around the pendant breast. The simulation uses an analytical expression or ray-tracing to generate projection sets of breast phantoms at 1 keV intervals dictated by the input x-ray energy spectra. The x-ray focal spot was modeled as having a Gaussian distribution. The detector was modeled as an amorphous silicon (aSi:H) flat-panel imager that uses a structured CsI scintillator. Noise propagation through the detector was simulated by modeling statistical variations of the projection images at each energy interval as a scaled Poisson process. Scintillator blurring was simulated by using an empirically determined modulation transfer function. After introducing noise and detector blur, projection sets simulated at each energy were then combined and reconstructed using Feldkamp's cone-beam reconstruction algorithm. Using this framework, the effects of a number of acquisition and reconstruction parameters can be investigated. Some examples are shown including the impact of the kVp setting and the number of projection angles on the reconstructed image.

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