Computational analysis of aerosol-dynamics in a human whole-lung airway model

[1]  E. Weibel.  Morphometry of the Human Lung , 1965, Springer Berlin Heidelberg.

[2]  D E Olson,et al.  Models of the human bronchial tree. , 1971, Journal of applied physiology.

[3]  J E Hansen,et al.  Human air space shapes, sizes, areas, and volumes. , 1975, Journal of applied physiology.

[4]  D. Taulbee,et al.  A theory of aerosol deposition in the human respiratory tract. , 1975, Journal of applied physiology.

[5]  J. Heyder,et al.  Total deposition of aerosol particles in the human respiratory tract for nose and mouth breathing , 1975 .

[6]  H. Yeh,et al.  Models of human lung airways and their application to inhaled particle deposition , 1980 .

[7]  T. Martonen.  Analytical model of hygroscopic particle behavior in human airways. , 1982, Bulletin of mathematical biology.

[8]  J. Heyder,et al.  Deposition of particles in the human respiratory tract in the size range 0.005–15 μm , 1986 .

[9]  E R Weibel,et al.  Morphometry of the human pulmonary acinus , 1988, The Anatomical record.

[10]  G. Rudolf,et al.  Intercomparison of Experimental Regional Aerosol Deposition Data , 1989 .

[11]  W. Hofmann,et al.  Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure , 1990 .

[12]  Icrp.  Human Respiratory Tract Model for Radiological Protection , 1994 .

[13]  S. Newman,et al.  A comparison of the lung deposition of budesonide from Easyhaler, Turbuhaler and pMDI plus spacer in asthmatic patients. , 2001, Respiratory medicine.

[14]  W. Hofmann,et al.  Particle Deposition in a Multiple-Path Model of the Human Lung , 2001 .

[15]  W. Finlay,et al.  In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices. , 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[16]  Y. Cheng,et al.  Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. , 2001, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[17]  S. Newman,et al.  Radionuclide imaging technologies and their use in evaluating asthma drug deposition in the lungs. , 2003, Advanced drug delivery reviews.

[18]  W. Finlay,et al.  Improved numerical simulation of aerosol deposition in an idealized mouth-throat , 2004 .

[19]  L. Borgström,et al.  Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose Inhaler , 1995, Pharmaceutical Research.

[20]  Ananth V. Annapragada,et al.  Computational Fluid Dynamics Simulation of Airflow and Aerosol Deposition in Human Lungs , 2004, Annals of Biomedical Engineering.

[21]  Clement Kleinstreuer,et al.  Comparison of micro- and nano-size particle depositions in a human upper airway model , 2005 .

[22]  R. Suedee,et al.  The study of in vitro-in vivo correlation: pharmacokinetics and pharmacodynamics of albuterol dry powder inhalers. , 2005, Journal of pharmaceutical sciences.

[23]  Kenneth R. Lutchen,et al.  An Anatomically Based Hybrid Computational Model of the Human Lung and its Application to Low Frequency Oscillatory Mechanics , 2006, Annals of Biomedical Engineering.

[24]  C. S. Kim,et al.  Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: empirical equations for sex and breathing pattern. , 2006, Journal of applied physiology.

[25]  W. Finlay,et al.  Modeling of aerosol deposition with interface devices. , 2007, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[26]  H. Derendorf.  Pharmacokinetic and Pharmacodynamic Properties of Inhaled Ciclesonide , 2007, Journal of clinical pharmacology.

[27]  Clement Kleinstreuer,et al.  Airflow and Nanoparticle Deposition in a 16-Generation Tracheobronchial Airway Model , 2008, Annals of Biomedical Engineering.

[28]  Andrew R. Martin,et al.  Recent advances in predictive understanding of respiratory tract deposition. , 2008, Journal of aerosol medicine and pulmonary drug delivery.

[29]  M. Goldberg,et al.  A Systematic Review of the Relation Between Long-term Exposure to Ambient Air Pollution and Chronic Diseases , 2008, Reviews on environmental health.

[30]  B. Belkassem,et al.  Large eddy and detached eddy simulations of fluid flow and particle deposition in a human mouth–throat , 2008 .

[31]  Kenneth R. Lutchen,et al.  CFD Simulation of Aerosol Deposition in an Anatomically Based Human Large–Medium Airway Model , 2009, Annals of Biomedical Engineering.

[32]  N. Chaiyaratana,et al.  Variable-length haplotype construction for geneߝgene interaction studies , 2009, IEEE Engineering in Medicine and Biology Magazine.

[33]  Marianne Geiser,et al.  Deposition and biokinetics of inhaled nanoparticles , 2010, Particle and Fibre Toxicology.

[34]  Jianjun Liu,et al.  SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells , 2010, Particle and Fibre Toxicology.

[35]  Ewald R Weibel,et al.  What makes a good lung? , 2009, Swiss medical weekly.

[36]  C Kleinstreuer,et al.  An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways. , 2009, Journal of biomechanical engineering.

[37]  D. Keith Walters,et al.  A Method for Three-Dimensional Navier–Stokes Simulations of Large-Scale Regions of the Human Lung Airway , 2010 .

[38]  Clement Kleinstreuer,et al.  Airflow and Particle Transport in the Human Respiratory System , 2010 .

[39]  Jiwoong Choi,et al.  Simulation of pulmonary air flow with a subject-specific boundary condition. , 2010, Journal of biomechanics.

[40]  R. Robinson,et al.  Flow in a terminal alveolar sac model with expanding walls using computational fluid dynamics , 2010, Inhalation toxicology.

[41]  J. Fleming,et al.  Deposition, imaging, and clearance: what remains to be done? , 2010, Journal of aerosol medicine and pulmonary drug delivery.

[42]  P. Worth Longest,et al.  Development of a stochastic individual path (SIP) model for predicting the tracheobronchial deposition of pharmaceutical aerosols: Effects of transient inhalation and sampling the airways , 2011 .

[43]  C. Kleinstreuer,et al.  Laminar‐to‐turbulent fluid–nanoparticle dynamics simulations: Model comparisons and nanoparticle‐deposition applications , 2011 .

[44]  R. Robinson,et al.  Stereoscopic particle image velocimetry analysis of healthy and emphysemic alveolar sac models. , 2011, Journal of biomechanical engineering.

[45]  W. Hofmann,et al.  Modelling inhaled particle deposition in the human lung—A review , 2011 .

[46]  C. Kleinstreuer,et al.  Computational analysis of airflow and nanoparticle deposition in a combined nasal–oral–tracheobronchial airway model , 2011 .

[47]  Jason H T Bates,et al.  Multi-scale lung modeling. , 2011, Journal of applied physiology.

[48]  Caroline Majoral,et al.  Controlled, parametric, individualized, 2-D and 3-D imaging measurements of aerosol deposition in the respiratory tract of healthy human subjects for model validation , 2012 .

[49]  P Worth Longest,et al.  In vitro tests for aerosol deposition. I: Scaling a physical model of the upper airways to predict drug deposition variation in normal humans. , 2012, Journal of aerosol medicine and pulmonary drug delivery.

[50]  J. Conway.  Lung imaging - two dimensional gamma scintigraphy, SPECT, CT and PET. , 2012, Advanced drug delivery reviews.

[51]  Clement Kleinstreuer,et al.  Nanoparticle mass transfer from lung airways to systemic regions--Part I: Whole-lung aerosol dynamics. , 2013, Journal of biomechanical engineering.

[52]  Jiwoong Choi,et al.  A multiscale MDCT image-based breathing lung model with time-varying regional ventilation , 2013, J. Comput. Phys..

[53]  Arun V. Kolanjiyil,et al.  Nanoparticle mass transfer from lung airways to systemic regions--Part II: Multi-compartmental modeling. , 2013, Journal of biomechanical engineering.

[54]  Clement Kleinstreuer,et al.  Analysis of non-spherical particle transport in complex internal shear flows , 2013 .

[55]  FlemingJohn,et al.  Controlled, Parametric, Individualized, 2-D and 3-D Imaging Measurements of Aerosol Deposition in the Respiratory Tract of Asthmatic Human Subjects for Model Validation , 2015 .

[56]  P. Worth Longest,et al.  Validating CFD Predictions of Pharmaceutical Aerosol Deposition with In Vivo Data , 2015, Pharmaceutical Research.

[57]  Geng Tian,et al.  Validating Whole-Airway CFD Predictions of DPI Aerosol Deposition at Multiple Flow Rates. , 2016, Journal of aerosol medicine and pulmonary drug delivery.

[58]  J. Fine,et al.  Total and regional deposition of inhaled aerosols in supine healthy subjects and subjects with mild-to-moderate COPD. , 2016, Journal of aerosol science.

[59]  Clement Kleinstreuer,et al.  Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation , 2016, Comput. Biol. Medicine.

[60]  S. Eberl,et al.  Examining the ability of empirical correlations to predict subject specific in vivo extrathoracic aerosol deposition during tidal breathing , 2017 .

[61]  T. Gemci,et al.  Pulmonary aerosol transport and deposition analysis in upper 17 generations of the human respiratory tract , 2017 .

[62]  Clement Kleinstreuer,et al.  Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part II: Dry powder inhaler application , 2017, Comput. Biol. Medicine.

[63]  C. Grandmont,et al.  Aerosol transport throughout inspiration and expiration in the pulmonary airways , 2017, International journal for numerical methods in biomedical engineering.

[64]  A. Przekwas,et al.  Pharmaceutical aerosols deposition patterns from a Dry Powder Inhaler: Euler Lagrangian prediction and validation. , 2017, Medical engineering & physics.