Effect of physiology on the temperature distribution of a layered head with external convection

Abstract To improve the existing thermal models of the human head, we incorporate the effect of the temperature over the metabolic heat generation, the regulatory processes that control the cerebral blood perfusion and their dependence on physiological parameters like, the mean arterial blood pressure, the partial pressure of oxygen, the partial pressure of carbon dioxide, and the cerebral metabolic rate of oxygen consumption. The introduction of these parameters in a thermal model gives information about how specific conditions, such as brain edema, hypoxia, hypercapnia, or hypotension, affect the temperature distribution within the brain. Our work, on a layered head model, shows that variations of the physiological parameters have profound effect on the temperature gradients within the head.

[1]  D. Bohn,et al.  A canine study of cold water drowning in fresh versus salt water. , 1995, Critical care medicine.

[2]  D. Nelson,et al.  Brain temperature and limits on transcranial cooling in humans: quantitative modeling results , 1998, European Journal of Applied Physiology and Occupational Physiology.

[3]  A. Laptook,et al.  Differences in brain temperature and cerebral blood flow during selective head versus whole-body cooling. , 2001, Pediatrics.

[4]  Toby F. Block,et al.  Chemistry Science of Change , 1993 .

[5]  A. Laptook,et al.  Modest Hypothermia Provides Partial Neuroprotection when Used for Immediate Resuscitation after Brain Ischemia , 1997, Pediatric Research.

[6]  J van der Aa,et al.  A computer model of intracranial dynamics integrated to a full-scale patient simulator. , 1998, Computers and biomedical research, an international journal.

[7]  P Tikuisis,et al.  A mathematical model for human brain cooling during cold-water near-drowning. , 1999, Journal of applied physiology.

[8]  B. Siesjö,et al.  Brain energy metabolism , 1978 .

[9]  Yildiz Bayazitoglu,et al.  Elements of Heat Transfer , 1988 .

[10]  Jan J W Lagendijk,et al.  Numerical Modeling of Temperature Distributions within the Neonatal Head , 2000, Pediatric Research.

[11]  H. H. Pennes Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948. , 1948, Journal of applied physiology.

[12]  George S. Dulikravich,et al.  Finite Element Simulation of Cooling of Realistic 3-D Human Head and Neck , 2002 .

[13]  M. A. Baker,et al.  Carotid Rete and Brain Temperature of Cat , 1967, Nature.

[14]  J. Phillis The Regulation of Cerebral Blood Flow , 1993 .

[15]  M. A. Baker,et al.  A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals. , 1969, Brain research.

[16]  W. Payne,et al.  Effect of carbon dioxide on rate of brain cooling during induction of hypothermia by direct blood cooling. , 1963, The Journal of surgical research.