论文信息 - Drug-induced glucose-6-phosphate dehydrogenase deficiency-related hemolysis risk assessment

Drug-induced glucose-6-phosphate dehydrogenase deficiency-related hemolysis risk assessment

Glucose-6-phosphate dehydrogenase (G6PD) is an essential enzyme that protects human red blood cells from premature destruction caused by oxidative damage. People suffering from G6PD deficiency would be vulnerable to various oxidative substances, such as fava beans and oxidant drugs. Until now, many institutes, organizations or domain experts have compiled low-risk or high-risk drugs collection for patients with G6PD deficiency, mainly from the case report or clinical trails. Recently, we have explored a classification system to predict drug-induced hemolytic potential. In this paper, we screen the normally used over-the-counter (OTC) drugs for "high-risk" and "low-risk" ones to G6PD deficient patients by this system.

Yang Yang | Xiaoyan Zhang | Zuofeng Li | Peng Nan

[1] R. J. Dern,et al. The hemolytic effect of primaquine. VI. An in vitro test for sensitivity of erythrocytes to primaquine. , 1955, The Journal of laboratory and clinical medicine.

[2] Jack J. Pasternak. An Introduction to Human Molecular Genetics: Mechanisms of Inherited Diseases , 2000 .

[3] Angelo Balestrieri,et al. Treatment of chronic hepatitis C in patients with glucose-6-phosphate dehydrogenase deficiency: is ribavirin harmful? , 2006, Blood.

[4] Geoffrey I. Webb,et al. Efficient lazy elimination for averaged one-dependence estimators , 2006, ICML.

[5] Ali R Elyassi,et al. Perioperative management of the glucose-6-phosphate dehydrogenase deficient patient: a review of literature. , 2009, Anesthesia progress.

[6] Geoffrey I. Webb,et al. Not So Naive Bayes: Aggregating One-Dependence Estimators , 2005, Machine Learning.

[7] M. Berkovitch,et al. Medications and Glucose-6-Phosphate Dehydrogenase Deficiency , 2010, Drug safety.

[8] Ernest Beutler,et al. Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development. , 2007, The American journal of tropical medicine and hygiene.