Network model of pulsatile hemodynamics in the microcirculation of the rabbit omentum.

GROSS, JOSEPH F., MARCOS INTAGLIETTA, AND BENJAMIN W. ZWEIFACH. Network model of pulsatile lzemodynamics in the microcirculation of the rabbit omentum. Am. J. Physiol. 226(5) : 1117-l 123. 1974.-Pulsatile pressure and red cell velocities were measured throughout the microvasculature of the rabbit omentum as a function of the order of branching. The data were analyzed in terms of a network model that incorporates known structural properties of the microvessels at each level of branching. Pulsatile effects are described by a “pressure diffusion” equation, where the diffusion coefficient is determined by the dimensions and mechanical properties of the . microvessels at each order of branching. Experimental and theoretical results show that measurable pressure and velocity pulsatile effects persist through this microvascular bed. Pressure and flow amplitudes were found to decay and the corresponding phase was found to increase, which indicates that this microcirculatory network behaves as a relatively compliant system. Effects in the semipermeable microvessels could be accounted for by compliance due to exchange as well as by compliance due to elasticity. Pressure amplitude and phase were found to be a more sensitive index of changes in structural properties in the microcirculation than corresponding velocity effects.

[1]  J F Gross,et al.  Mathematical models of capillary flow: a critical review. , 1972, Biorheology.

[2]  W. R. Tompkins,et al.  On-line measurement of microvascular dimensions by television microscopy. , 1972, Journal of applied physiology.

[3]  M Intaglietta,et al.  Blood pressure, flow, and elastic properties in microvessels of cat omentum. , 1971, The American journal of physiology.

[4]  B. Zweifach,et al.  Geometrical Model of the Microvasculature of Rabbit Omentum from in Vivo Measurements , 1971 .

[5]  W. R. Tompkins,et al.  Velocity measurements in the microvasculature of the cat omentum by on-line method. , 1970, Microvascular research.

[6]  W. R. Tompkins,et al.  Pressure measurements in the mammalian microvasculature. , 1970, Microvascular research.

[7]  P. Gaehtgens,et al.  Erythrocyte flow velocities in mesenteric microvessels of the cat. , 1970, Microvascular research.

[8]  M. Raphael,et al.  The origin of the pulmonary densitometric pulse. , 1969, The British journal of radiology.

[9]  W. Rosenblum Erythrocyte Velocity and a Velocity Pulse in Minute Blood Vessels on the Surface of the Mouse Brain , 1969, Circulation research.

[10]  A Noordergraaf,et al.  Input impedance, wave travel, and reflections in the human pulmonary arterial tree: studies using an electrical analog. , 1968, IEEE transactions on bio-medical engineering.

[11]  J. Greenfield,et al.  IMPEDANCE OF CERTAIN LARGE BLOOD VESSELS IN MAN , 1964, Annals of the New York Academy of Sciences.

[12]  John W. Irwin,et al.  A manometer for measuring dynamic pressures in the microvascular system , 1959 .

[13]  E. Landis MICRO-INJECTION STUDIES OF CAPILLARY PERMEABILITY , 1927 .